CAV_DROYA
ID CAV_DROYA Reviewed; 319 AA.
AC B4PKZ7; B6UW57; O16047;
DT 07-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT 23-SEP-2008, sequence version 1.
DT 03-AUG-2022, entry version 50.
DE RecName: Full=Telomere-binding protein cav {ECO:0000250|UniProtKB:Q95RV2};
DE AltName: Full=Anon-EST:fe1G5 {ECO:0000312|EMBL:EDW98982.1};
GN Name=cav {ECO:0000250|UniProtKB:Q95RV2};
GN Synonyms=anon-EST:fe1G5 {ECO:0000312|EMBL:EDW98982.1}; ORFNames=GE23460;
OS Drosophila yakuba (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7245;
RN [1] {ECO:0000312|EMBL:AAB81483.1}
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=9275195; DOI=10.1073/pnas.94.18.9746;
RA Schmid K.J., Tautz D.;
RT "A screen for fast evolving genes from Drosophila.";
RL Proc. Natl. Acad. Sci. U.S.A. 94:9746-9750(1997).
RN [2] {ECO:0000312|EMBL:EDW98982.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tai18E2 / Tucson 14021-0261.01 {ECO:0000312|EMBL:EDW98982.1};
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
RN [3] {ECO:0000312|EMBL:ACI96380.1}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-141.
RX PubMed=18984573; DOI=10.1534/genetics.108.093807;
RA Anderson J.A., Gilliland W.D., Langley C.H.;
RT "Molecular population genetics and evolution of Drosophila meiosis genes.";
RL Genetics 181:177-185(2009).
CC -!- FUNCTION: Binds to chromosome ends in a sequence-dependent manner and
CC is required for telomere capping. {ECO:0000250|UniProtKB:Q95RV2}.
CC -!- SUBUNIT: Interacts (via C-terminus) with Su(var)205 dimer (via hinge
CC and chromoshadow domain) and with moi to form the terminin, telomere-
CC capping, complex. Interacts with HP6, which is also part of the
CC terminin complex (By similarity). {ECO:0000250|UniProtKB:Q95RV2}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q95RV2}.
CC Chromosome, telomere {ECO:0000250|UniProtKB:Q95RV2}.
CC -!- MISCELLANEOUS: Multiple telomeric associations (TAs) in the same
CC metaphase spread often result in multicentric linear chromosomes that
CC resemble little 'trains' of chromosomes, hence the name 'caravaggio',
CC an Italian train.
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DR EMBL; AF005852; AAB81483.1; -; mRNA.
DR EMBL; CM000160; EDW98982.1; -; Genomic_DNA.
DR EMBL; FJ218755; ACI96380.1; -; Genomic_DNA.
DR RefSeq; XP_002099270.1; XM_002099234.2.
DR AlphaFoldDB; B4PKZ7; -.
DR STRING; 7245.FBpp0268470; -.
DR EnsemblMetazoa; FBtr0269978; FBpp0268470; FBgn0022414.
DR GeneID; 6538756; -.
DR KEGG; dya:Dyak_GE23460; -.
DR eggNOG; ENOG502RN8H; Eukaryota.
DR HOGENOM; CLU_059636_0_0_1; -.
DR OMA; QINSESM; -.
DR OrthoDB; 1158010at2759; -.
DR PhylomeDB; B4PKZ7; -.
DR ChiTaRS; cav; fly.
DR Proteomes; UP000002282; Chromosome 3R.
DR GO; GO:0000775; C:chromosome, centromeric region; IEA:EnsemblMetazoa.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000782; C:telomere cap complex; ISS:UniProtKB.
DR GO; GO:0042162; F:telomeric DNA binding; ISS:UniProtKB.
DR GO; GO:0016233; P:telomere capping; ISS:UniProtKB.
PE 2: Evidence at transcript level;
KW Chromosome; DNA-binding; Nucleus; Repeat; Telomere.
FT CHAIN 1..319
FT /note="Telomere-binding protein cav"
FT /id="PRO_0000379492"
FT REGION 107..312
FT /note="Required for binding to Su(var)205"
FT /evidence="ECO:0000250|UniProtKB:Q95RV2"
FT REGION 141..163
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 186..248
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 291..319
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 220..224
FT /note="Su(var)205-binding Pro-containing repeat 1"
FT /evidence="ECO:0000255"
FT MOTIF 273..279
FT /note="Su(var)205-binding Pro-containing repeat 2"
FT /evidence="ECO:0000255"
FT COMPBIAS 233..248
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 81
FT /note="K -> R (in Ref. 1; AAB81483)"
FT /evidence="ECO:0000305"
FT CONFLICT 232
FT /note="G -> A (in Ref. 1; AAB81483)"
FT /evidence="ECO:0000305"
FT CONFLICT 244
FT /note="D -> E (in Ref. 1; AAB81483)"
FT /evidence="ECO:0000305"
FT CONFLICT 302
FT /note="G -> A (in Ref. 1; AAB81483)"
FT /evidence="ECO:0000305"
FT CONFLICT 318
FT /note="V -> ARDV (in Ref. 1; AAB81483)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 319 AA; 36929 MW; A013F8AB188D8D6B CRC64;
MSGMQISSYL RKYLADEDKK IREEFKESDP NNEMILWMHE KTRITEEDLA RPYTEDEVRE
LCLRTKVKVN MTAWNCLWEA KKRFDAKGRF ERKSEEFINL MYLKAVRRKM VQPYPEDYVA
QRREIAAAET KKDNISRLDR WQKQKRRNQS AHATQPDSQD NEVVEIHDDT NRYSVSQAVA
LPVLTPSDLS GIGDDEDEQQ QQHHHHKHRS GFQNEHADCP ETQMRCDQAD SGRLPNGPTN
SESDPDYYMF GTQLSRSIQP TSTQEADDQL ACPETEMNES WVRCDQINSE SMSIGPSINS
DGSISFQNSG SEPIDVDVN
