CAX1C_ORYSJ
ID CAX1C_ORYSJ Reviewed; 450 AA.
AC Q5KTQ9; A0A0P0VI98; C7IY34; Q6Z6R2;
DT 30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT 15-FEB-2005, sequence version 1.
DT 03-AUG-2022, entry version 99.
DE RecName: Full=Vacuolar cation/proton exchanger 1c;
DE AltName: Full=Ca(2+)/H(+) exchanger 1c;
DE AltName: Full=OsCAX1c;
GN Name=CAX1c;
GN OrderedLocusNames=Os02g0314300, Os02g0314400, Os02g0314100, LOC_Os02g21009;
GN ORFNames=P0705A04.26;
OS Oryza sativa subsp. japonica (Rice).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX NCBI_TaxID=39947;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND TISSUE SPECIFICITY.
RX PubMed=16043430; DOI=10.1093/pcp/pci173;
RA Kamiya T., Akahori T., Maeshima M.;
RT "Expression profile of the genes for rice cation/h+ exchanger family and
RT functional analysis in yeast.";
RL Plant Cell Physiol. 46:1735-1740(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=16100779; DOI=10.1038/nature03895;
RG International rice genome sequencing project (IRGSP);
RT "The map-based sequence of the rice genome.";
RL Nature 436:793-800(2005).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=18089549; DOI=10.1093/nar/gkm978;
RG The rice annotation project (RAP);
RT "The rice annotation project database (RAP-DB): 2008 update.";
RL Nucleic Acids Res. 36:D1028-D1033(2008).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT "Improvement of the Oryza sativa Nipponbare reference genome using next
RT generation sequence and optical map data.";
RL Rice 6:4-4(2013).
CC -!- FUNCTION: Vacuolar cation/proton exchanger (CAX). Translocates Ca(2+)
CC and other metal ions into vacuoles using the proton gradient formed by
CC H(+)-ATPase and H(+)-pyrophosphatase. {ECO:0000269|PubMed:16043430}.
CC -!- SUBCELLULAR LOCATION: Vacuole membrane {ECO:0000305}; Multi-pass
CC membrane protein {ECO:0000305}. Note=Tonoplast.
CC -!- TISSUE SPECIFICITY: Expressed in leaf blades.
CC {ECO:0000269|PubMed:16043430}.
CC -!- SIMILARITY: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19)
CC family. Cation/proton exchanger (CAX) subfamily. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAD15983.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AB112771; BAD83661.1; -; mRNA.
DR EMBL; AP004891; BAD15983.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AP008208; BAH91649.1; -; Genomic_DNA.
DR EMBL; AP014958; BAS78336.1; -; Genomic_DNA.
DR RefSeq; XP_015622639.1; XM_015767153.1.
DR AlphaFoldDB; Q5KTQ9; -.
DR SMR; Q5KTQ9; -.
DR STRING; 4530.OS02T0314300-00; -.
DR PaxDb; Q5KTQ9; -.
DR PRIDE; Q5KTQ9; -.
DR EnsemblPlants; Os02t0314300-00; Os02t0314300-00; Os02g0314300.
DR GeneID; 9269067; -.
DR Gramene; Os02t0314300-00; Os02t0314300-00; Os02g0314300.
DR KEGG; osa:9269067; -.
DR eggNOG; KOG1397; Eukaryota.
DR HOGENOM; CLU_008721_2_0_1; -.
DR InParanoid; Q5KTQ9; -.
DR OMA; SAMVWLI; -.
DR OrthoDB; 727723at2759; -.
DR Proteomes; UP000000763; Chromosome 2.
DR Proteomes; UP000059680; Chromosome 2.
DR Genevisible; Q5KTQ9; OS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0009705; C:plant-type vacuole membrane; IBA:GO_Central.
DR GO; GO:0015369; F:calcium:proton antiporter activity; IBA:GO_Central.
DR GO; GO:0070588; P:calcium ion transmembrane transport; IBA:GO_Central.
DR GO; GO:0006874; P:cellular calcium ion homeostasis; IBA:GO_Central.
DR Gene3D; 1.20.1420.30; -; 2.
DR InterPro; IPR004713; CaH_exchang.
DR InterPro; IPR004798; CAX-like.
DR InterPro; IPR004837; NaCa_Exmemb.
DR InterPro; IPR044880; NCX_ion-bd_dom_sf.
DR PANTHER; PTHR31503; PTHR31503; 1.
DR Pfam; PF01699; Na_Ca_ex; 2.
DR TIGRFAMs; TIGR00378; cax; 1.
PE 2: Evidence at transcript level;
KW Antiport; Calcium; Calcium transport; Ion transport; Membrane;
KW Reference proteome; Transmembrane; Transmembrane helix; Transport; Vacuole.
FT CHAIN 1..450
FT /note="Vacuolar cation/proton exchanger 1c"
FT /id="PRO_0000209499"
FT TOPO_DOM 1..73
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 74..94
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 95..101
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 102..122
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 123..134
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 135..155
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 156..170
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 171..191
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 192..201
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 202..222
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 223..239
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 240..260
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 261..287
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 288..308
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 309..331
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 332..352
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 353..360
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 361..381
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 382..385
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 386..406
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 407..424
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 425..445
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 446..450
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT REGION 28..52
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 143..178
FT /note="Cation selection"
FT /evidence="ECO:0000255"
FT REGION 339..374
FT /note="Cation selection"
FT /evidence="ECO:0000255"
SQ SEQUENCE 450 AA; 48164 MW; B23DD3F2C72C5734 CRC64;
MAPPESSHHH LLESGLLEVS KAPSAAVAAE EEEKKEAAAW TPSSSSSMTG RKIKSEASPL
LRRLLGGPAA QLQEVLLGTK LYPLFSAVPL AVAAESLRLG RVWVFAFSLI GLAPLAERVS
FLSEHIANTV GPTAGGIMNA TCGNVPELII ALFALHKNKM EILKWSLLGS ILSNLLLVLG
SSLLFGGIVN IGKERPLDKR QADVSIGLLL LGVLCHIATL VSKYTSSTGD SINSSSVMQL
SRSCAIVMLI AYFGSLMFQL KTHRQIFELE EDSSDSSSSE DDATDKSVIG FASAMVWLIG
MAVVTAMLSS YVVTTIEEAS ESMGIPVRFI SIILLPIVGN AAEHAGAIIF AFKNKIDISL
GITLGSATQI SMLVVPVILI VSWVNAIPMD LDFNLLETGS LAMAVITTAF TLQDDKWHYL
KGLNLVFSYI VIAVCFFVMK ALPTLKKEDD
