ID   CAXA_ALKAM              Reviewed;         319 AA.
AC   Q0ZAI3;
DT   19-MAR-2014, integrated into UniProtKB/Swiss-Prot.
DT   22-AUG-2006, sequence version 1.
DT   03-AUG-2022, entry version 32.
DE   RecName: Full=Putative antiporter CaxA;
GN   Name=caxA; Synonyms=chaA;
OS   Alkalimonas amylolytica.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Alkalimonas.
OX   NCBI_TaxID=152573;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, AND GENE NAME.
RC   STRAIN=N10;
RX   PubMed=17600061; DOI=10.1099/mic.0.2007/007450-0;
RA   Wei Y., Liu J., Ma Y., Krulwich T.A.;
RT   "Three putative cation/proton antiporters from the soda lake alkaliphile
RT   Alkalimonas amylolytica N10 complement an alkali-sensitive Escherichia coli
RT   mutant.";
RL   Microbiology 153:2168-2179(2007).
CC   -!- FUNCTION: Confers modest Ca(2+) and Na(+) resistance.
CC       {ECO:0000269|PubMed:17600061}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19)
CC       family. {ECO:0000305}.
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DR   EMBL; DQ649017; ABG37980.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q0ZAI3; -.
DR   SMR; Q0ZAI3; -.
DR   STRING; 152573.SAMN04488051_101627; -.
DR   TCDB; 2.A.19.5.2; the ca(2+):cation antiporter (caca) family.
DR   GO; GO:0005887; C:integral component of plasma membrane; IEA:UniProt.
DR   GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1420.30; -; 2.
DR   InterPro; IPR004481; K/Na/Ca-exchanger.
DR   InterPro; IPR004837; NaCa_Exmemb.
DR   InterPro; IPR044880; NCX_ion-bd_dom_sf.
DR   PANTHER; PTHR10846; PTHR10846; 2.
DR   Pfam; PF01699; Na_Ca_ex; 2.
DR   TIGRFAMs; TIGR00367; TIGR00367; 1.
PE   3: Inferred from homology;
KW   Antiport; Cell membrane; Membrane; Transmembrane; Transmembrane helix;
KW   Transport.
FT   CHAIN           1..319
FT                   /note="Putative antiporter CaxA"
FT                   /id="PRO_0000425721"
FT   TRANSMEM        3..23
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        38..58
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        81..101
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        105..125
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        127..147
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        175..195
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        208..228
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        250..270
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        275..292
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        297..317
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   319 AA;  33652 MW;  669A617F79B3A7E7 CRC64;
     MLVATIFVLV GLVLLIWSAD RFVYGASSIA RNLNISPMII GLTIVAMGSS APEIMVSATA
     AWQGRLDTAV GNALGSNITN ILLVIGATAL LKPIAVASMT IKREFPLLIL VTLLGYLFLA
     DQSLTRAEGA LFLGGFVLFL VLMVYWGKHA PPDDPLLTEY QAELPPPTPT WQATVWLVLG
     LALLLASSQL LVHGAVTIAS HFGMSDLLIG LTIIAIGTSL PELAASLIGI LKGEDDLALG
     NIIGSNIFNI LAVLGVGTII APGVIDAAAA GRDSYVMMAA TLALLLMSLR LGKLRRINRV
     EGCILLMAFI GYQYLLFSS