ID   CAX_SYNY3               Reviewed;         372 AA.
AC   P74072;
DT   19-MAR-2014, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1997, sequence version 1.
DT   25-MAY-2022, entry version 106.
DE   RecName: Full=Ca(2+)/H(+) antiporter;
DE   AltName: Full=SynCAX;
GN   OrderedLocusNames=slr1336;
OS   Synechocystis sp. (strain PCC 6803 / Kazusa).
OC   Bacteria; Cyanobacteria; Synechococcales; Merismopediaceae; Synechocystis;
OC   unclassified Synechocystis.
OX   NCBI_TaxID=1111708;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PCC 6803 / Kazusa;
RX   PubMed=8905231; DOI=10.1093/dnares/3.3.109;
RA   Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y.,
RA   Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T.,
RA   Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S.,
RA   Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT   "Sequence analysis of the genome of the unicellular cyanobacterium
RT   Synechocystis sp. strain PCC6803. II. Sequence determination of the entire
RT   genome and assignment of potential protein-coding regions.";
RL   DNA Res. 3:109-136(1996).
RN   [2]
RP   FUNCTION, BIOPHYSICOCHEMICAL PROPERTIES, SUBCELLULAR LOCATION, AND
RP   DISRUPTION PHENOTYPE.
RC   STRAIN=PCC 6803 / Kazusa;
RX   PubMed=14559898; DOI=10.1074/jbc.m310282200;
RA   Waditee R., Hossain G.S., Tanaka Y., Nakamura T., Shikata M., Takano J.,
RA   Takabe T., Takabe T.;
RT   "Isolation and functional characterization of Ca2+/H+ antiporters from
RT   cyanobacteria.";
RL   J. Biol. Chem. 279:4330-4338(2004).
CC   -!- FUNCTION: Ca(+)/H(+) antiporter that extrudes calcium in exchange for
CC       external protons. Plays an important role in salt tolerance. Does not
CC       transport sodium or lithium. {ECO:0000269|PubMed:14559898}.
CC   -!- BIOPHYSICOCHEMICAL PROPERTIES:
CC       pH dependence:
CC         Optimum pH is 8.0. {ECO:0000269|PubMed:14559898};
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane
CC       {ECO:0000269|PubMed:14559898}; Multi-pass membrane protein
CC       {ECO:0000269|PubMed:14559898}.
CC   -!- DISRUPTION PHENOTYPE: Disruption causes the rapid degradation of
CC       pigments and salt-sensitive phenotype at alkaline pH.
CC       {ECO:0000269|PubMed:14559898}.
CC   -!- SIMILARITY: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19)
CC       family. Cation/proton exchanger (CAX) subfamily. {ECO:0000305}.
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DR   EMBL; BA000022; BAA18148.1; -; Genomic_DNA.
DR   PIR; S75587; S75587.
DR   AlphaFoldDB; P74072; -.
DR   SMR; P74072; -.
DR   TCDB; 2.A.19.2.1; the ca(2+):cation antiporter (caca) family.
DR   PaxDb; P74072; -.
DR   EnsemblBacteria; BAA18148; BAA18148; BAA18148.
DR   KEGG; syn:slr1336; -.
DR   eggNOG; COG0387; Bacteria.
DR   InParanoid; P74072; -.
DR   OMA; AAVMITC; -.
DR   PhylomeDB; P74072; -.
DR   Proteomes; UP000001425; Chromosome.
DR   GO; GO:0005887; C:integral component of plasma membrane; IDA:UniProtKB.
DR   GO; GO:0015369; F:calcium:proton antiporter activity; IDA:UniProtKB.
DR   GO; GO:0070588; P:calcium ion transmembrane transport; IDA:UniProtKB.
DR   GO; GO:0006874; P:cellular calcium ion homeostasis; IBA:GO_Central.
DR   Gene3D; 1.20.1420.30; -; 2.
DR   InterPro; IPR004713; CaH_exchang.
DR   InterPro; IPR004798; CAX-like.
DR   InterPro; IPR004837; NaCa_Exmemb.
DR   InterPro; IPR044880; NCX_ion-bd_dom_sf.
DR   PANTHER; PTHR31503; PTHR31503; 1.
DR   Pfam; PF01699; Na_Ca_ex; 2.
DR   TIGRFAMs; TIGR00378; cax; 1.
PE   1: Evidence at protein level;
KW   Antiport; Calcium; Calcium transport; Cell inner membrane; Cell membrane;
KW   Ion transport; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..372
FT                   /note="Ca(2+)/H(+) antiporter"
FT                   /id="PRO_0000425711"
FT   TRANSMEM        7..27
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        29..49
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        62..82
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        94..114
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        134..154
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        162..182
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        222..242
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        251..271
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        294..314
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        320..340
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        352..372
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   372 AA;  39311 MW;  A7A2FFEA9A23332F CRC64;
     MSTKSKIFLV LLVFCPLSFA AHWLGWGETT VFILAGLAIV PLAAFMGTAT EEIAVVIGPN
     AGGLLNATFG NATELILAYI ALKEGLIEVV KATLTGSIIG NLLLVMGFAV FLGGLRYKEQ
     NFQPLAARLN ASTMNLGVVA ILLPTALQYT STGVEETVLQ NLSVAVAVVL IGVYLLSLVF
     SMGTHAYLYD VGVAENMEMP ELGEDVSEPE PPTEEEKPNL WLWTGVLLVV TLGVAVESEL
     LVGSLEVATE SLGLTALFTG VIVLPIIGNA AEHATAVTVA MKDKMDLSMS VVMGSSLQIA
     FFVAPVLVIV GWAIGQPMDL NFNPFELVAV LVAVLIVNSI SSDGTSNWLE GILLLATYAI
     VALAFFFHPT LV