ID   YCGR_THISH              Reviewed;         246 AA.
AC   B8GQA2;
DT   13-JUL-2010, integrated into UniProtKB/Swiss-Prot.
DT   03-MAR-2009, sequence version 1.
DT   25-MAY-2022, entry version 56.
DE   RecName: Full=Flagellar brake protein YcgR {ECO:0000255|HAMAP-Rule:MF_01457};
DE   AltName: Full=Cyclic di-GMP binding protein YcgR {ECO:0000255|HAMAP-Rule:MF_01457};
GN   Name=ycgR {ECO:0000255|HAMAP-Rule:MF_01457}; OrderedLocusNames=Tgr7_1211;
OS   Thioalkalivibrio sulfidiphilus (strain HL-EbGR7).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Chromatiales;
OC   Ectothiorhodospiraceae; Thioalkalivibrio.
OX   NCBI_TaxID=396588;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=HL-EbGR7;
RX   PubMed=21475584; DOI=10.4056/sigs.1483693;
RA   Muyzer G., Sorokin D.Y., Mavromatis K., Lapidus A., Clum A., Ivanova N.,
RA   Pati A., d'Haeseleer P., Woyke T., Kyrpides N.C.;
RT   "Complete genome sequence of 'Thioalkalivibrio sulfidophilus' HL-EbGr7.";
RL   Stand. Genomic Sci. 4:23-35(2011).
CC   -!- FUNCTION: Acts as a flagellar brake, regulating swimming and swarming
CC       in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)-dependent manner.
CC       Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead
CC       to decreased motility. {ECO:0000255|HAMAP-Rule:MF_01457}.
CC   -!- SUBUNIT: Monomer. Interacts with the flagellar basal bodies.
CC       {ECO:0000255|HAMAP-Rule:MF_01457}.
CC   -!- SUBCELLULAR LOCATION: Bacterial flagellum basal body
CC       {ECO:0000255|HAMAP-Rule:MF_01457}.
CC   -!- SIMILARITY: Belongs to the YcgR family. {ECO:0000255|HAMAP-
CC       Rule:MF_01457}.
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DR   EMBL; CP001339; ACL72297.1; -; Genomic_DNA.
DR   RefSeq; WP_012637780.1; NC_011901.1.
DR   AlphaFoldDB; B8GQA2; -.
DR   SMR; B8GQA2; -.
DR   STRING; 396588.Tgr7_1211; -.
DR   EnsemblBacteria; ACL72297; ACL72297; Tgr7_1211.
DR   KEGG; tgr:Tgr7_1211; -.
DR   eggNOG; COG5581; Bacteria.
DR   HOGENOM; CLU_1174300_0_0_6; -.
DR   OMA; VERFVYQ; -.
DR   OrthoDB; 1600481at2; -.
DR   Proteomes; UP000002383; Chromosome.
DR   GO; GO:0009425; C:bacterial-type flagellum basal body; IEA:UniProtKB-SubCell.
DR   GO; GO:0035438; F:cyclic-di-GMP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0071973; P:bacterial-type flagellum-dependent cell motility; IEA:UniProtKB-UniRule.
DR   GO; GO:0071945; P:regulation of bacterial-type flagellum-dependent cell motility by regulation of motor speed; IEA:UniProtKB-UniRule.
DR   Gene3D; 2.30.110.10; -; 1.
DR   HAMAP; MF_01457; YcgR; 1.
DR   InterPro; IPR009875; PilZ_domain.
DR   InterPro; IPR012349; Split_barrel_FMN-bd.
DR   InterPro; IPR023787; T3SS_YcgR.
DR   InterPro; IPR009926; T3SS_YcgR_PilZN.
DR   Pfam; PF07238; PilZ; 1.
DR   Pfam; PF07317; YcgR; 1.
PE   3: Inferred from homology;
KW   Bacterial flagellum; c-di-GMP; Nucleotide-binding; Reference proteome.
FT   CHAIN           1..246
FT                   /note="Flagellar brake protein YcgR"
FT                   /id="PRO_0000395287"
FT   DOMAIN          128..232
FT                   /note="PilZ"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01457"
SQ   SEQUENCE   246 AA;  27441 MW;  D08799C144B0E1F1 CRC64;
     MNETPAVPPS PEVEGSLNEQ ISHRRRILAV LDAMKDGRAL LSARIENQRG YFNTTLLKID
     AEKGYVFLDE LAPADGHEKI AVGQTLHLYG FYNNLPAHFA IEVIHVGEHE GIAFYAGPLP
     KLIHYQQKRA HFRAYVGLGK ELKVRLRKGD GAQISGRLQD ISLGGFGALM PADSVFEDLE
     IVEVEALELP DHHAIACSAE IRHSHPTQGR VHIGARFTQL APQAERQLLQ AIVELEREQL
     RKQSRD