YCGZ_ECOLI
ID YCGZ_ECOLI Reviewed; 78 AA.
AC P75991; Q2MBH1;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1997, sequence version 1.
DT 03-AUG-2022, entry version 115.
DE RecName: Full=Probable two-component-system connector protein YcgZ;
GN Name=ycgZ; OrderedLocusNames=b1164, JW1151;
OS Escherichia coli (strain K12).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83333;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA Shao Y.;
RT "The complete genome sequence of Escherichia coli K-12.";
RL Science 277:1453-1462(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=16738553; DOI=10.1038/msb4100049;
RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT and W3110.";
RL Mol. Syst. Biol. 2:E1-E5(2006).
RN [3]
RP INDUCTION BY COLD SHOCK.
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=14527658; DOI=10.1016/s0923-2508(03)00167-0;
RA Polissi A., De Laurentis W., Zangrossi S., Briani F., Longhi V., Pesole G.,
RA Deho G.;
RT "Changes in Escherichia coli transcriptome during acclimatization at low
RT temperature.";
RL Res. Microbiol. 154:573-580(2003).
RN [4]
RP INDUCTION BY COLD SHOCK, AND RPOS-DEPENDENCE.
RC STRAIN=K12 / MC4100;
RX PubMed=18174134; DOI=10.1099/mic.0.2007/012021-0;
RA White-Ziegler C.A., Um S., Perez N.M., Berns A.L., Malhowski A.J.,
RA Young S.;
RT "Low temperature (23 degrees C) increases expression of biofilm-, cold-
RT shock- and RpoS-dependent genes in Escherichia coli K-12.";
RL Microbiology 154:148-166(2008).
RN [5]
RP INDUCTION BY 5-FLUOROURACIL.
RC STRAIN=K12 / ATCC 25404 / DSM 5698 / NCIMB 11290;
RX PubMed=19172264; DOI=10.1007/s00253-009-1860-8;
RA Attila C., Ueda A., Wood T.K.;
RT "5-Fluorouracil reduces biofilm formation in Escherichia coli K-12 through
RT global regulator AriR as an antivirulence compound.";
RL Appl. Microbiol. Biotechnol. 82:525-533(2009).
RN [6]
RP INDUCTION BY COLD SHOCK, RPOS-DEPENDENCE, REPRESSION BY YCGE, AND OPERON
RP STRUCTURE.
RC STRAIN=K12 / MC4100;
RX PubMed=19240136; DOI=10.1101/gad.499409;
RA Tschowri N., Busse S., Hengge R.;
RT "The BLUF-EAL protein YcgF acts as a direct anti-repressor in a blue-light
RT response of Escherichia coli.";
RL Genes Dev. 23:522-534(2009).
CC -!- FUNCTION: Probably a connector protein for RcsB/C regulation of biofilm
CC formation, providing additional signal input into the two-component
CC signaling pathway. Partially antagonizes the activities of YmgA and
CC AriR, proteins that, via the Rcs phosphorelay, promote the synthesis of
CC colanic acid, an exopolysaccharide and matrix component.
CC -!- INDUCTION: Expressed constitutively at low levels, slightly induced
CC upon entry into stationary phase at 37 degrees Celsius. Induced by 5-
CC fluorouracil. Strongly induced at 16 and 23 degrees Celsius. Expression
CC is partially dependent on RpoS, it is repressed by YcgE. At 16 degrees
CC Celsius with blue light irradiation, expression of this operon is
CC absolutely dependent on YcgF for relief from YcgE repression. Part of
CC the ycgZ-ymgA-ariR-ymgC operon. {ECO:0000269|PubMed:14527658,
CC ECO:0000269|PubMed:18174134, ECO:0000269|PubMed:19172264,
CC ECO:0000269|PubMed:19240136}.
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DR EMBL; U00096; AAC74248.1; -; Genomic_DNA.
DR EMBL; AP009048; BAE76385.1; -; Genomic_DNA.
DR PIR; A64862; A64862.
DR RefSeq; NP_415682.1; NC_000913.3.
DR RefSeq; WP_000554140.1; NZ_SSZK01000010.1.
DR AlphaFoldDB; P75991; -.
DR SMR; P75991; -.
DR BioGRID; 4259500; 7.
DR IntAct; P75991; 9.
DR STRING; 511145.b1164; -.
DR jPOST; P75991; -.
DR PaxDb; P75991; -.
DR PRIDE; P75991; -.
DR EnsemblBacteria; AAC74248; AAC74248; b1164.
DR EnsemblBacteria; BAE76385; BAE76385; BAE76385.
DR GeneID; 945885; -.
DR KEGG; ecj:JW1151; -.
DR KEGG; eco:b1164; -.
DR PATRIC; fig|1411691.4.peg.1126; -.
DR EchoBASE; EB4036; -.
DR eggNOG; ENOG5032RTK; Bacteria.
DR HOGENOM; CLU_164045_0_0_6; -.
DR OMA; NPMIEND; -.
DR BioCyc; EcoCyc:G6604-MON; -.
DR PRO; PR:P75991; -.
DR Proteomes; UP000000318; Chromosome.
DR Proteomes; UP000000625; Chromosome.
DR GO; GO:0071468; P:cellular response to acidic pH; IEA:InterPro.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IMP:EcoCyc.
DR InterPro; IPR024753; AriR.
DR Pfam; PF10798; YmgB; 1.
PE 2: Evidence at transcript level;
KW Reference proteome.
FT CHAIN 1..78
FT /note="Probable two-component-system connector protein
FT YcgZ"
FT /id="PRO_0000168861"
SQ SEQUENCE 78 AA; 8769 MW; B3A1EBA656403534 CRC64;
MHQNSVTLDS AGAITRYFAK ANLHTQQETL GEIVTEILKD GRNLSRKSLC AKLLCRLEHA
TGEEEQKHYN ALIGLLFE
