CAYP2_HUMAN
ID CAYP2_HUMAN Reviewed; 557 AA.
AC Q9BXY5; Q6PH84; Q8N242; Q8NAY5;
DT 29-AUG-2003, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2005, sequence version 2.
DT 03-AUG-2022, entry version 160.
DE RecName: Full=Calcyphosin-2;
DE AltName: Full=Calcyphosine-2;
GN Name=CAPS2; ORFNames=UG0636c06;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), AND TISSUE SPECIFICITY.
RX PubMed=11846421; DOI=10.1006/bbrc.2002.6461;
RA Wang S., Chen J.-Z., Zhang Z., Huang Q., Gu S., Ying K., Xie Y., Mao Y.;
RT "Cloning, characterization, and expression of calcyphosine 2, a novel human
RT gene encoding an EF-hand Ca(2+)-binding protein.";
RL Biochem. Biophys. Res. Commun. 291:414-420(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND NUCLEOTIDE SEQUENCE
RP [LARGE SCALE MRNA] OF 197-557 (ISOFORMS 1/2).
RC TISSUE=Tongue;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 33-557 (ISOFORMS 1/2).
RC TISSUE=Fetal brain;
RA Mao Y., Xie Y.;
RT "Isolation of full-length cDNA clones from human fetal brain cDNA
RT library.";
RL Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q9BXY5-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9BXY5-2; Sequence=VSP_014408, VSP_014410;
CC Name=3;
CC IsoId=Q9BXY5-3; Sequence=VSP_014408, VSP_014409;
CC -!- TISSUE SPECIFICITY: Abundantly expressed in many tissues. Expressed in
CC brain, colon, heart, kidney, liver, lung, liver, pancreas, placenta,
CC skeletal muscle, testis and thymus. Highest expression in colon,
CC testis, lung, placenta and brain. {ECO:0000269|PubMed:11846421}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAN76511.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=BAC03845.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AF251056; AAK34946.1; -; mRNA.
DR EMBL; AK091839; BAC03759.1; -; mRNA.
DR EMBL; AK092274; BAC03845.1; ALT_INIT; mRNA.
DR EMBL; BC056672; AAH56672.1; -; mRNA.
DR EMBL; AF351611; AAN76511.1; ALT_INIT; mRNA.
DR CCDS; CCDS73497.1; -. [Q9BXY5-2]
DR CCDS; CCDS9008.2; -. [Q9BXY5-1]
DR PIR; JC7811; JC7811.
DR RefSeq; NP_001273477.1; NM_001286548.1. [Q9BXY5-2]
DR RefSeq; NP_115995.2; NM_032606.3. [Q9BXY5-1]
DR RefSeq; XP_005269251.1; XM_005269194.3. [Q9BXY5-3]
DR RefSeq; XP_011537194.1; XM_011538892.1.
DR RefSeq; XP_016875525.1; XM_017020036.1. [Q9BXY5-2]
DR RefSeq; XP_016875526.1; XM_017020037.1.
DR RefSeq; XP_016875527.1; XM_017020038.1.
DR AlphaFoldDB; Q9BXY5; -.
DR SMR; Q9BXY5; -.
DR STRING; 9606.ENSP00000386959; -.
DR iPTMnet; Q9BXY5; -.
DR PhosphoSitePlus; Q9BXY5; -.
DR BioMuta; CAPS2; -.
DR DMDM; 68840161; -.
DR jPOST; Q9BXY5; -.
DR MassIVE; Q9BXY5; -.
DR PaxDb; Q9BXY5; -.
DR PeptideAtlas; Q9BXY5; -.
DR PRIDE; Q9BXY5; -.
DR ProteomicsDB; 79542; -. [Q9BXY5-1]
DR ProteomicsDB; 79543; -. [Q9BXY5-2]
DR ProteomicsDB; 79544; -. [Q9BXY5-3]
DR Antibodypedia; 29581; 110 antibodies from 22 providers.
DR DNASU; 84698; -.
DR Ensembl; ENST00000393284.8; ENSP00000376963.4; ENSG00000180881.20.
DR Ensembl; ENST00000409445.8; ENSP00000386959.4; ENSG00000180881.20.
DR GeneID; 84698; -.
DR KEGG; hsa:84698; -.
DR UCSC; uc001sxk.4; human. [Q9BXY5-1]
DR CTD; 84698; -.
DR DisGeNET; 84698; -.
DR GeneCards; CAPS2; -.
DR HGNC; HGNC:16471; CAPS2.
DR HPA; ENSG00000180881; Tissue enhanced (retina).
DR MIM; 607724; gene.
DR neXtProt; NX_Q9BXY5; -.
DR PharmGKB; PA38405; -.
DR VEuPathDB; HostDB:ENSG00000180881; -.
DR eggNOG; KOG0032; Eukaryota.
DR HOGENOM; CLU_036726_3_0_1; -.
DR InParanoid; Q9BXY5; -.
DR OMA; AHIHFNP; -.
DR OrthoDB; 562989at2759; -.
DR PhylomeDB; Q9BXY5; -.
DR TreeFam; TF323924; -.
DR PathwayCommons; Q9BXY5; -.
DR BioGRID-ORCS; 84698; 10 hits in 1053 CRISPR screens.
DR ChiTaRS; CAPS2; human.
DR GenomeRNAi; 84698; -.
DR Pharos; Q9BXY5; Tdark.
DR PRO; PR:Q9BXY5; -.
DR Proteomes; UP000005640; Chromosome 12.
DR RNAct; Q9BXY5; protein.
DR Bgee; ENSG00000180881; Expressed in bronchial epithelial cell and 147 other tissues.
DR ExpressionAtlas; Q9BXY5; baseline and differential.
DR Genevisible; Q9BXY5; HS.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR CDD; cd00051; EFh; 1.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR002048; EF_hand_dom.
DR SMART; SM00054; EFh; 2.
DR SUPFAM; SSF47473; SSF47473; 1.
DR PROSITE; PS50222; EF_HAND_2; 3.
PE 2: Evidence at transcript level;
KW Alternative splicing; Calcium; Metal-binding; Reference proteome; Repeat.
FT CHAIN 1..557
FT /note="Calcyphosin-2"
FT /id="PRO_0000073540"
FT DOMAIN 445..480
FT /note="EF-hand 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT DOMAIN 481..516
FT /note="EF-hand 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT DOMAIN 517..552
FT /note="EF-hand 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT REGION 153..173
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 458
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000305"
FT BINDING 462
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000305"
FT BINDING 469
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000305"
FT BINDING 496
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000305"
FT BINDING 498
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000305"
FT BINDING 500
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000305"
FT BINDING 505
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000305"
FT BINDING 530
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="3"
FT /evidence="ECO:0000305"
FT BINDING 532
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="3"
FT /evidence="ECO:0000305"
FT BINDING 534
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="3"
FT /evidence="ECO:0000305"
FT BINDING 536
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="3"
FT /evidence="ECO:0000305"
FT BINDING 541
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="3"
FT /evidence="ECO:0000305"
FT VAR_SEQ 1..232
FT /note="Missing (in isoform 2 and isoform 3)"
FT /evidence="ECO:0000303|PubMed:11846421,
FT ECO:0000303|PubMed:15489334"
FT /id="VSP_014408"
FT VAR_SEQ 304..335
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_014409"
FT VAR_SEQ 557
FT /note="G -> GHSTEEEIKSSFLETLKVACSKSDEVSYGEFEDYYEGLSIGIVDDED
FT FVNILRTPWGI (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:11846421"
FT /id="VSP_014410"
FT VARIANT 125
FT /note="L -> F (in dbSNP:rs10879901)"
FT /id="VAR_061085"
FT CONFLICT 186
FT /note="D -> G (in Ref. 4; AAN76511)"
FT /evidence="ECO:0000305"
FT CONFLICT 487
FT /note="E -> G (in Ref. 2; BAC03845)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 557 AA; 63835 MW; F592985889A010EE CRC64;
MGNSFCYTAV YCMINTGTQM DLEVKGVAAT SRSQIQPFFG RKKPLQQRWT SESWTNQNSC
PPVVPRLDLG SLVDSDDEDN FSYIPLSTAN LPNSSSTLGW VTPCQTPYTQ YHLNKLDQNI
IPENLPAPTD KCKLKYQQCK TEIKEGYKQY SQRNAENTKS NVTHKQSPRN KIDEKCVQDE
EANTDDLTTL DRKAILQQGY ADNSCDKQQR ARKLDAEIVA AEKKKQIVAE QVMIDHLSRA
VISDPEQNLA IEQKESDHIL PDSKMTPLRF RKRTLHETKI RTHSTLTENV LSHKLQFDGR
IVSRNGRDAC RELIGFFFTH DQSLTIYEYR QFGKNRTNVL PFIQKSIYSH QCGRRKGKQY
RLGDFYVGAT LTFLSSDHLS LPESIKENTL LKLRITNIDQ IALDSLKTAS MEQEDDIIIQ
ETNDRLVFKA IQDVLKEKLH KRGVRILTGL GKYFQQLDKE GNGLLDKADF KQALKVFHLE
VSEKDFESAW LILNDNGNGK VDYGEFKRGI IGEMNEYRKS YVRKAFMKLD FNKSGSVPII
NIRKCYCAKK HSQVISG
