ID   YCIA_ECOLI              Reviewed;         132 AA.
AC   P0A8Z0; P04379;
DT   20-MAR-1987, integrated into UniProtKB/Swiss-Prot.
DT   20-MAR-1987, sequence version 1.
DT   03-AUG-2022, entry version 117.
DE   RecName: Full=Acyl-CoA thioester hydrolase YciA;
DE            EC=3.1.2.-;
DE   AltName: Full=Protein P14;
GN   Name=yciA; OrderedLocusNames=b1253, JW1245;
OS   Escherichia coli (strain K12).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83333;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2985285; DOI=10.1016/s0092-8674(85)80030-1;
RA   Postle K., Good R.F.;
RT   "A bidirectional rho-independent transcription terminator between the E.
RT   coli tonB gene and an opposing gene.";
RL   Cell 41:577-585(1985).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ECOR 1, ECOR 16, ECOR 28, ECOR 31, ECOR 37, ECOR 4, ECOR 46,
RC   ECOR 52, ECOR 60, ECOR 71, K12, and O2:HN / ECOR 50 / P97 / UPEC;
RA   Milkman R.;
RL   Submitted (APR-1995) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX   PubMed=9097039; DOI=10.1093/dnares/3.6.363;
RA   Aiba H., Baba T., Fujita K., Hayashi K., Inada T., Isono K., Itoh T.,
RA   Kasai H., Kashimoto K., Kimura S., Kitakawa M., Kitagawa M., Makino K.,
RA   Miki T., Mizobuchi K., Mori H., Mori T., Motomura K., Nakade S.,
RA   Nakamura Y., Nashimoto H., Nishio Y., Oshima T., Saito N., Sampei G.,
RA   Seki Y., Sivasundaram S., Tagami H., Takeda J., Takemoto K., Takeuchi Y.,
RA   Wada C., Yamamoto Y., Horiuchi T.;
RT   "A 570-kb DNA sequence of the Escherichia coli K-12 genome corresponding to
RT   the 28.0-40.1 min region on the linkage map.";
RL   DNA Res. 3:363-377(1996).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA   Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA   Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA   Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA   Shao Y.;
RT   "The complete genome sequence of Escherichia coli K-12.";
RL   Science 277:1453-1462(1997).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX   PubMed=16738553; DOI=10.1038/msb4100049;
RA   Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA   Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT   "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT   and W3110.";
RL   Mol. Syst. Biol. 2:E1-E5(2006).
RN   [6]
RP   FUNCTION.
RX   PubMed=15808744; DOI=10.1016/j.fmrre.2004.12.006;
RA   Kuznetsova E., Proudfoot M., Sanders S.A., Reinking J., Savchenko A.,
RA   Arrowsmith C.H., Edwards A.M., Yakunin A.F.;
RT   "Enzyme genomics: application of general enzymatic screens to discover new
RT   enzymes.";
RL   FEMS Microbiol. Rev. 29:263-279(2005).
CC   -!- FUNCTION: Catalyzes the hydrolysis of the thioester bond in palmitoyl-
CC       CoA and malonyl-CoA. {ECO:0000269|PubMed:15808744}.
CC   -!- SIMILARITY: Belongs to the acyl coenzyme A hydrolase family.
CC       {ECO:0000305}.
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DR   EMBL; K00431; AAB59067.1; -; Genomic_DNA.
DR   EMBL; U24195; AAB60068.1; -; Genomic_DNA.
DR   EMBL; U24196; AAB60076.1; -; Genomic_DNA.
DR   EMBL; U24197; AAB60084.1; -; Genomic_DNA.
DR   EMBL; U24198; AAB60092.1; -; Genomic_DNA.
DR   EMBL; U24199; AAB60100.1; -; Genomic_DNA.
DR   EMBL; U24200; AAB60108.1; -; Genomic_DNA.
DR   EMBL; U24201; AAB60116.1; -; Genomic_DNA.
DR   EMBL; U24202; AAB60124.1; -; Genomic_DNA.
DR   EMBL; U24203; AAB60132.1; -; Genomic_DNA.
DR   EMBL; U24204; AAB60140.1; -; Genomic_DNA.
DR   EMBL; U24205; AAB60148.1; -; Genomic_DNA.
DR   EMBL; U24206; AAB60156.1; -; Genomic_DNA.
DR   EMBL; U00096; AAC74335.1; -; Genomic_DNA.
DR   EMBL; AP009048; BAA14785.1; -; Genomic_DNA.
DR   PIR; A05224; A05224.
DR   RefSeq; NP_415769.1; NC_000913.3.
DR   RefSeq; WP_000108160.1; NZ_STEB01000005.1.
DR   AlphaFoldDB; P0A8Z0; -.
DR   SMR; P0A8Z0; -.
DR   BioGRID; 4262997; 21.
DR   DIP; DIP-35956N; -.
DR   IntAct; P0A8Z0; 14.
DR   STRING; 511145.b1253; -.
DR   jPOST; P0A8Z0; -.
DR   PaxDb; P0A8Z0; -.
DR   PRIDE; P0A8Z0; -.
DR   EnsemblBacteria; AAC74335; AAC74335; b1253.
DR   EnsemblBacteria; BAA14785; BAA14785; BAA14785.
DR   GeneID; 66674925; -.
DR   GeneID; 946634; -.
DR   KEGG; ecj:JW1245; -.
DR   KEGG; eco:b1253; -.
DR   PATRIC; fig|1411691.4.peg.1030; -.
DR   EchoBASE; EB1111; -.
DR   eggNOG; COG1607; Bacteria.
DR   HOGENOM; CLU_050164_2_0_6; -.
DR   InParanoid; P0A8Z0; -.
DR   OMA; MDEMAFL; -.
DR   PhylomeDB; P0A8Z0; -.
DR   BioCyc; EcoCyc:EG11121-MON; -.
DR   BioCyc; MetaCyc:EG11121-MON; -.
DR   BRENDA; 3.1.2.2; 2026.
DR   BRENDA; 3.1.2.20; 2026.
DR   PRO; PR:P0A8Z0; -.
DR   Proteomes; UP000000318; Chromosome.
DR   Proteomes; UP000000625; Chromosome.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0047617; F:acyl-CoA hydrolase activity; IDA:EcoCyc.
DR   GO; GO:0036042; F:long-chain fatty acyl-CoA binding; IBA:GO_Central.
DR   GO; GO:0016290; F:palmitoyl-CoA hydrolase activity; IDA:EcoCyc.
DR   GO; GO:0006637; P:acyl-CoA metabolic process; IBA:GO_Central.
DR   GO; GO:0044581; P:butyryl-CoA catabolic process to butyrate; IMP:EcoCyc.
DR   GO; GO:0006631; P:fatty acid metabolic process; IBA:GO_Central.
DR   InterPro; IPR040170; Cytosol_ACT.
DR   InterPro; IPR033120; HOTDOG_ACOT.
DR   InterPro; IPR029069; HotDog_dom_sf.
DR   InterPro; IPR006683; Thioestr_dom.
DR   PANTHER; PTHR11049; PTHR11049; 1.
DR   Pfam; PF03061; 4HBT; 1.
DR   SUPFAM; SSF54637; SSF54637; 1.
DR   PROSITE; PS51770; HOTDOG_ACOT; 1.
PE   3: Inferred from homology;
KW   Hydrolase; Reference proteome.
FT   CHAIN           1..132
FT                   /note="Acyl-CoA thioester hydrolase YciA"
FT                   /id="PRO_0000053817"
FT   DOMAIN          8..123
FT                   /note="HotDog ACOT-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01106"
SQ   SEQUENCE   132 AA;  14231 MW;  EF29C49DBB6B50DA CRC64;
     MSTTHNVPQG DLVLRTLAMP ADTNANGDIF GGWLMSQMDI GGAILAKEIA HGRVVTVRVE
     GMTFLRPVAV GDVVCCYARC VQKGTTSVSI NIEVWVKKVA SEPIGQRYKA TEALFKYVAV
     DPEGKPRALP VE