YCIC_ECOLI
ID YCIC_ECOLI Reviewed; 247 AA.
AC P21365; P77207; P94718; P94724; P94727; P94731; P94734; P94737; P97230;
DT 01-MAY-1991, integrated into UniProtKB/Swiss-Prot.
DT 11-JUL-2003, sequence version 2.
DT 03-AUG-2022, entry version 131.
DE RecName: Full=UPF0259 membrane protein YciC;
GN Name=yciC; OrderedLocusNames=b1255, JW1247;
OS Escherichia coli (strain K12).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83333;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=K12;
RX PubMed=3058546; DOI=10.1093/genetics/120.2.345;
RA Stoltzfus A., Leslie J.F., Milkman R.;
RT "Molecular evolution of the Escherichia coli chromosome. I. Analysis of
RT structure and natural variation in a previously uncharacterized region
RT between trp and tonB.";
RL Genetics 120:345-358(1988).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ECOR 1, ECOR 16, ECOR 28, ECOR 31, ECOR 37, ECOR 4, ECOR 46,
RC ECOR 52, ECOR 60, ECOR 71, K12, and O2:HN / ECOR 50 / P97 / UPEC;
RA Milkman R.;
RL Submitted (APR-1995) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=9097039; DOI=10.1093/dnares/3.6.363;
RA Aiba H., Baba T., Fujita K., Hayashi K., Inada T., Isono K., Itoh T.,
RA Kasai H., Kashimoto K., Kimura S., Kitakawa M., Kitagawa M., Makino K.,
RA Miki T., Mizobuchi K., Mori H., Mori T., Motomura K., Nakade S.,
RA Nakamura Y., Nashimoto H., Nishio Y., Oshima T., Saito N., Sampei G.,
RA Seki Y., Sivasundaram S., Tagami H., Takeda J., Takemoto K., Takeuchi Y.,
RA Wada C., Yamamoto Y., Horiuchi T.;
RT "A 570-kb DNA sequence of the Escherichia coli K-12 genome corresponding to
RT the 28.0-40.1 min region on the linkage map.";
RL DNA Res. 3:363-377(1996).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA Shao Y.;
RT "The complete genome sequence of Escherichia coli K-12.";
RL Science 277:1453-1462(1997).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=16738553; DOI=10.1038/msb4100049;
RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT and W3110.";
RL Mol. Syst. Biol. 2:E1-E5(2006).
RN [6]
RP TOPOLOGY [LARGE SCALE ANALYSIS].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=15919996; DOI=10.1126/science.1109730;
RA Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.;
RT "Global topology analysis of the Escherichia coli inner membrane
RT proteome.";
RL Science 308:1321-1323(2005).
CC -!- SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the UPF0259 family. {ECO:0000305}.
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DR EMBL; X13583; CAA31923.1; -; Genomic_DNA.
DR EMBL; U24195; AAB60066.1; -; Genomic_DNA.
DR EMBL; U24196; AAB60074.1; -; Genomic_DNA.
DR EMBL; U24197; AAB60082.1; -; Genomic_DNA.
DR EMBL; U24198; AAB60090.1; -; Genomic_DNA.
DR EMBL; U24199; AAB60098.1; -; Genomic_DNA.
DR EMBL; U24200; AAB60106.1; -; Genomic_DNA.
DR EMBL; U24201; AAB60114.1; -; Genomic_DNA.
DR EMBL; U24202; AAB60122.1; -; Genomic_DNA.
DR EMBL; U24203; AAB60130.1; -; Genomic_DNA.
DR EMBL; U24204; AAB60138.1; -; Genomic_DNA.
DR EMBL; U24205; AAB60146.1; -; Genomic_DNA.
DR EMBL; U24206; AAB60154.1; -; Genomic_DNA.
DR EMBL; U00096; AAC74337.1; -; Genomic_DNA.
DR EMBL; AP009048; BAA14787.1; -; Genomic_DNA.
DR PIR; B64873; B64873.
DR PIR; T45502; T45502.
DR RefSeq; NP_415771.1; NC_000913.3.
DR RefSeq; WP_000028545.1; NZ_LN832404.1.
DR AlphaFoldDB; P21365; -.
DR BioGRID; 4262999; 21.
DR STRING; 511145.b1255; -.
DR PaxDb; P21365; -.
DR PRIDE; P21365; -.
DR EnsemblBacteria; AAC74337; AAC74337; b1255.
DR EnsemblBacteria; BAA14787; BAA14787; BAA14787.
DR GeneID; 66674923; -.
DR GeneID; 945844; -.
DR KEGG; ecj:JW1247; -.
DR KEGG; eco:b1255; -.
DR PATRIC; fig|1411691.4.peg.1028; -.
DR EchoBASE; EB1113; -.
DR eggNOG; ENOG502Z96Y; Bacteria.
DR HOGENOM; CLU_073287_0_0_6; -.
DR OMA; FFRNQFV; -.
DR PhylomeDB; P21365; -.
DR BioCyc; EcoCyc:EG11123-MON; -.
DR PRO; PR:P21365; -.
DR Proteomes; UP000000318; Chromosome.
DR Proteomes; UP000000625; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IDA:EcoCyc.
DR HAMAP; MF_01067; UPF0259; 1.
DR InterPro; IPR009627; UPF0259.
PE 1: Evidence at protein level;
KW Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..247
FT /note="UPF0259 membrane protein YciC"
FT /id="PRO_0000206514"
FT TOPO_DOM 1..19
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 20..40
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 41..86
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 87..107
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 108..117
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 118..140
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 141..151
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 152..172
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 173..186
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 187..209
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 210..224
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 225..245
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 246..247
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT VARIANT 26
FT /note="V -> I (in strain: ECOR 52)"
FT VARIANT 46
FT /note="A -> V (in strain: ECOR 31)"
FT VARIANT 65
FT /note="D -> N (in strain: ECOR 16)"
FT VARIANT 119
FT /note="I -> V (in strain: ECOR 60)"
FT VARIANT 172
FT /note="V -> I (in strain: ECOR 16, ECOR 28, ECOR 31, ECOR
FT 37, ECOR 50 and ECOR 71)"
FT VARIANT 233
FT /note="I -> V (in strain: ECOR 31, ECOR 46, ECOR 50, ECOR
FT 52 and ECOR 60)"
FT CONFLICT 100..114
FT /note="VILIIQLVSAGQRVS -> RNINYPAGVCGSESQ (in Ref. 1 and
FT 2)"
FT /evidence="ECO:0000305"
FT CONFLICT 191
FT /note="A -> T (in Ref. 1 and 2)"
FT /evidence="ECO:0000305"
FT CONFLICT 202
FT /note="T -> P (in Ref. 1 and 2)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 247 AA; 26419 MW; C2750BF3A8ECF069 CRC64;
MSITAQSVYR DTGNFFRNQF MTILLVSLLC AFITVVLGHV FSPSDAQLAQ LNDGVPVSGS
SGLFDLVQNM SPEQQQILLQ ASAASTFSGL IGNAILAGGV ILIIQLVSAG QRVSALRAIG
ASAPILPKLF ILIFLTTLLV QIGIMLVVVP GIIMAILLAL APVMLVQDKM GVFASMRSSM
RLTWANMRLV APAVLSWLLA KTLLLLFASS FAALTPEIGA VLANTLSNLI SAILLIYLFR
LYMLIRQ
