YCIK_ECOLI
ID YCIK_ECOLI Reviewed; 252 AA.
AC P31808; P77516;
DT 01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1997, sequence version 3.
DT 03-AUG-2022, entry version 150.
DE RecName: Full=Uncharacterized oxidoreductase YciK;
DE EC=1.-.-.-;
GN Name=yciK; OrderedLocusNames=b1271, JW1263;
OS Escherichia coli (strain K12).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83333;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=9097039; DOI=10.1093/dnares/3.6.363;
RA Aiba H., Baba T., Fujita K., Hayashi K., Inada T., Isono K., Itoh T.,
RA Kasai H., Kashimoto K., Kimura S., Kitakawa M., Kitagawa M., Makino K.,
RA Miki T., Mizobuchi K., Mori H., Mori T., Motomura K., Nakade S.,
RA Nakamura Y., Nashimoto H., Nishio Y., Oshima T., Saito N., Sampei G.,
RA Seki Y., Sivasundaram S., Tagami H., Takeda J., Takemoto K., Takeuchi Y.,
RA Wada C., Yamamoto Y., Horiuchi T.;
RT "A 570-kb DNA sequence of the Escherichia coli K-12 genome corresponding to
RT the 28.0-40.1 min region on the linkage map.";
RL DNA Res. 3:363-377(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA Shao Y.;
RT "The complete genome sequence of Escherichia coli K-12.";
RL Science 277:1453-1462(1997).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=16738553; DOI=10.1038/msb4100049;
RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT and W3110.";
RL Mol. Syst. Biol. 2:E1-E5(2006).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RA Milkman R., McKane M.;
RL Submitted (NOV-1994) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-63.
RX PubMed=1885549; DOI=10.1128/jb.173.18.5763-5770.1991;
RA Baird L., Lipinska B., Raina S., Georgopoulos C.;
RT "Identification of the Escherichia coli sohB gene, a multicopy suppressor
RT of the HtrA (DegP) null phenotype.";
RL J. Bacteriol. 173:5763-5770(1991).
CC -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR)
CC family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAB59991.1; Type=Frameshift; Evidence={ECO:0000305};
CC Sequence=AAB59992.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; U00096; AAC74353.1; -; Genomic_DNA.
DR EMBL; AP009048; BAA14808.1; -; Genomic_DNA.
DR EMBL; U17433; AAB59992.1; ALT_FRAME; Genomic_DNA.
DR EMBL; U17433; AAB59991.1; ALT_FRAME; Genomic_DNA.
DR EMBL; M73320; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR PIR; B64875; B64875.
DR RefSeq; NP_415787.1; NC_000913.3.
DR RefSeq; WP_000559286.1; NZ_SSZK01000031.1.
DR PDB; 3E9Q; X-ray; 1.70 A; A/B=1-252.
DR PDB; 3F1K; X-ray; 2.60 A; A=1-252.
DR PDB; 3F1L; X-ray; 0.95 A; A/B=1-252.
DR PDBsum; 3E9Q; -.
DR PDBsum; 3F1K; -.
DR PDBsum; 3F1L; -.
DR AlphaFoldDB; P31808; -.
DR SMR; P31808; -.
DR BioGRID; 4259576; 48.
DR IntAct; P31808; 6.
DR STRING; 511145.b1271; -.
DR jPOST; P31808; -.
DR PaxDb; P31808; -.
DR PRIDE; P31808; -.
DR EnsemblBacteria; AAC74353; AAC74353; b1271.
DR EnsemblBacteria; BAA14808; BAA14808; BAA14808.
DR GeneID; 945838; -.
DR KEGG; ecj:JW1263; -.
DR KEGG; eco:b1271; -.
DR PATRIC; fig|1411691.4.peg.1013; -.
DR EchoBASE; EB1709; -.
DR eggNOG; COG1028; Bacteria.
DR HOGENOM; CLU_010194_2_10_6; -.
DR InParanoid; P31808; -.
DR OMA; ETGPSFN; -.
DR PhylomeDB; P31808; -.
DR BioCyc; EcoCyc:EG11759-MON; -.
DR EvolutionaryTrace; P31808; -.
DR PRO; PR:P31808; -.
DR Proteomes; UP000000318; Chromosome.
DR Proteomes; UP000000625; Chromosome.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0016491; F:oxidoreductase activity; IBA:GO_Central.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR020904; Sc_DH/Rdtase_CS.
DR InterPro; IPR002347; SDR_fam.
DR Pfam; PF00106; adh_short; 1.
DR PRINTS; PR00081; GDHRDH.
DR SUPFAM; SSF51735; SSF51735; 1.
DR PROSITE; PS00061; ADH_SHORT; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Oxidoreductase; Reference proteome.
FT CHAIN 1..252
FT /note="Uncharacterized oxidoreductase YciK"
FT /id="PRO_0000054824"
FT ACT_SITE 165
FT /note="Proton acceptor"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU10001"
FT BINDING 16..40
FT /ligand="NADP(+)"
FT /ligand_id="ChEBI:CHEBI:58349"
FT /evidence="ECO:0000250"
FT BINDING 152
FT /ligand="substrate"
FT /evidence="ECO:0000250"
FT CONFLICT 63
FT /note="Q -> P (in Ref. 5)"
FT /evidence="ECO:0000305"
FT TURN 7..12
FT /evidence="ECO:0007829|PDB:3F1L"
FT STRAND 14..19
FT /evidence="ECO:0007829|PDB:3F1L"
FT HELIX 23..34
FT /evidence="ECO:0007829|PDB:3F1L"
FT STRAND 38..44
FT /evidence="ECO:0007829|PDB:3F1L"
FT HELIX 46..60
FT /evidence="ECO:0007829|PDB:3F1L"
FT STRAND 65..68
FT /evidence="ECO:0007829|PDB:3F1L"
FT TURN 71..73
FT /evidence="ECO:0007829|PDB:3F1L"
FT HELIX 76..89
FT /evidence="ECO:0007829|PDB:3F1L"
FT STRAND 94..98
FT /evidence="ECO:0007829|PDB:3F1L"
FT TURN 109..111
FT /evidence="ECO:0007829|PDB:3F1L"
FT HELIX 114..124
FT /evidence="ECO:0007829|PDB:3F1L"
FT HELIX 126..140
FT /evidence="ECO:0007829|PDB:3F1L"
FT STRAND 142..144
FT /evidence="ECO:0007829|PDB:3F1L"
FT STRAND 146..150
FT /evidence="ECO:0007829|PDB:3F1L"
FT HELIX 153..155
FT /evidence="ECO:0007829|PDB:3F1L"
FT HELIX 163..182
FT /evidence="ECO:0007829|PDB:3F1L"
FT TURN 183..186
FT /evidence="ECO:0007829|PDB:3F1L"
FT STRAND 188..193
FT /evidence="ECO:0007829|PDB:3F1L"
FT STRAND 196..199
FT /evidence="ECO:0007829|PDB:3F1L"
FT HELIX 200..205
FT /evidence="ECO:0007829|PDB:3F1L"
FT STRAND 207..209
FT /evidence="ECO:0007829|PDB:3F1K"
FT HELIX 211..213
FT /evidence="ECO:0007829|PDB:3F1L"
FT HELIX 218..220
FT /evidence="ECO:0007829|PDB:3F1L"
FT HELIX 221..228
FT /evidence="ECO:0007829|PDB:3F1L"
FT HELIX 230..232
FT /evidence="ECO:0007829|PDB:3F1L"
FT STRAND 239..243
FT /evidence="ECO:0007829|PDB:3F1L"
FT STRAND 248..250
FT /evidence="ECO:0007829|PDB:3F1K"
SQ SEQUENCE 252 AA; 27933 MW; 4F7D860BF8840F7A CRC64;
MHYQPKQDLL NDRIILVTGA SDGIGREAAM TYARYGATVI LLGRNEEKLR QVASHINEET
GRQPQWFILD LLTCTSENCQ QLAQRIAVNY PRLDGVLHNA GLLGDVCPMS EQNPQVWQDV
MQVNVNATFM LTQALLPLLL KSDAGSLVFT SSSVGRQGRA NWGAYAASKF ATEGMMQVLA
DEYQQRLRVN CINPGGTRTA MRASAFPTED PQKLKTPADI MPLYLWLMGD DSRRKTGMTF
DAQPGRKPGI SQ
