ID   YCKC_SCHPO              Reviewed;         821 AA.
AC   Q9Y7N9;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1999, sequence version 1.
DT   03-AUG-2022, entry version 109.
DE   RecName: Full=PX domain-containing protein C1450.12;
GN   ORFNames=SPCC1450.12;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
RN   [2]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-260; THR-597 AND SER-761, AND
RP   IDENTIFICATION BY MASS SPECTROMETRY.
RX   PubMed=18257517; DOI=10.1021/pr7006335;
RA   Wilson-Grady J.T., Villen J., Gygi S.P.;
RT   "Phosphoproteome analysis of fission yeast.";
RL   J. Proteome Res. 7:1088-1097(2008).
CC   -!- SUBCELLULAR LOCATION: Mitochondrion membrane {ECO:0000250}; Peripheral
CC       membrane protein {ECO:0000250}.
CC   -!- DOMAIN: The PX domain binds phosphatidylinositol 3-phosphate which is
CC       necessary for peripheral membrane localization.
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DR   EMBL; CU329672; CAB40179.1; -; Genomic_DNA.
DR   PIR; T40994; T40994.
DR   RefSeq; NP_588311.1; NM_001023301.2.
DR   AlphaFoldDB; Q9Y7N9; -.
DR   BioGRID; 275556; 7.
DR   STRING; 4896.SPCC1450.12.1; -.
DR   iPTMnet; Q9Y7N9; -.
DR   MaxQB; Q9Y7N9; -.
DR   PaxDb; Q9Y7N9; -.
DR   PRIDE; Q9Y7N9; -.
DR   EnsemblFungi; SPCC1450.12.1; SPCC1450.12.1:pep; SPCC1450.12.
DR   GeneID; 2538982; -.
DR   KEGG; spo:SPCC1450.12; -.
DR   PomBase; SPCC1450.12; -.
DR   VEuPathDB; FungiDB:SPCC1450.12; -.
DR   eggNOG; KOG2273; Eukaryota.
DR   HOGENOM; CLU_007739_1_1_1; -.
DR   InParanoid; Q9Y7N9; -.
DR   OMA; VAWNNAV; -.
DR   PhylomeDB; Q9Y7N9; -.
DR   PRO; PR:Q9Y7N9; -.
DR   Proteomes; UP000002485; Chromosome III.
DR   GO; GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005739; C:mitochondrion; ISO:PomBase.
DR   GO; GO:0035091; F:phosphatidylinositol binding; ISM:PomBase.
DR   Gene3D; 3.30.1520.10; -; 1.
DR   InterPro; IPR024554; DUF3818_PX-associated.
DR   InterPro; IPR024555; PX-associated.
DR   InterPro; IPR001683; PX_dom.
DR   InterPro; IPR036871; PX_dom_sf.
DR   Pfam; PF12825; DUF3818; 2.
DR   Pfam; PF00787; PX; 1.
DR   Pfam; PF12828; PXB; 1.
DR   SMART; SM00312; PX; 1.
DR   SUPFAM; SSF64268; SSF64268; 1.
DR   PROSITE; PS50195; PX; 1.
PE   1: Evidence at protein level;
KW   Membrane; Mitochondrion; Phosphoprotein; Reference proteome.
FT   CHAIN           1..821
FT                   /note="PX domain-containing protein C1450.12"
FT                   /id="PRO_0000315963"
FT   DOMAIN          171..310
FT                   /note="PX"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00147"
FT   REGION          235..271
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          737..766
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        244..267
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         260
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000269|PubMed:18257517"
FT   MOD_RES         597
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000269|PubMed:18257517"
FT   MOD_RES         761
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000269|PubMed:18257517"
SQ   SEQUENCE   821 AA;  96107 MW;  D31A30189F280FC4 CRC64;
     MDTASPEEID ALKRHYLKKE LFSLLIADEL NFVSEPTNLD HLGSPFVEKG KSVIPYEKSQ
     IPVLRFIFKR FILTFPFLDP DSQNQLWNVN FRNLLKSLSK SNVSVLPDDS DATHLHKWLL
     KFQNMLTLLM SRAFHSIQDE KNINIELLDT PKLEKDLHKS ELQQKPNILE AYVLGVRQST
     QAKMLRTKRV YEYLIKVSYE ENTFFIARKY SDFSHFHHLL LKSYPNAYVP RLPPKDDHDT
     YLNSSEDSTL SPLPSRSSDT NDPQSDSQHV LRQERMRIEL RQYIKNILND DELHLTEEVL
     SFLTDDPVTL TASELTDINF RQELDVIRQL EQQKFVEIAS QRAKELDVYM EEFKRSLTEN
     NGFTTLFTEL KEKNSISELS PSLQKTIEWA RVNLASTIYD TFIGKEKSLE TYLQIKKMHQ
     LFPYTVIKNI MRFSNPLSVM KRILDTLLAQ PFGMKSLFQR LLSISLNENV RAIHKLISRY
     EARIVSPEIL TKIQEQVENP CKAAREVLEK KQMKRHDYLY FILISDDVPP KLPDNLIRRV
     YAERTAWKAA LDSEDYPTDP TVIRRSKRYG YMMKLMHLYA KQFNKRRSIS LISEGATGEI
     MKSMVDSPEL NPNILVEQFI DLVRRHEDSF YDFVHRVYLH DSGLFASLME WIENIIGFLR
     QGTSAPIDMD LVVDALDEES RQALDVELNK LLKWNQRKKS ALFLRKTTKY IPGEETSLPV
     TMDELGIDEE IMAELRGDED DQDENDQVTK VEEEHMEDDD SVEEFDPIIE ERQRMKRKAN
     RPANIIPPKP KLRTVKTLLP AFKEQVYPIL HKFVSENEKD I