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YCP4_YEAST
ID   YCP4_YEAST              Reviewed;         247 AA.
AC   P25349; D6VR14;
DT   01-MAY-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1992, sequence version 1.
DT   03-AUG-2022, entry version 176.
DE   RecName: Full=Flavoprotein-like protein YCP4;
DE   Flags: Precursor;
GN   Name=YCP4; OrderedLocusNames=YCR004C; ORFNames=YCR042, YCR4C;
OS   Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=559292;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=1580102; DOI=10.1002/yea.320080107;
RA   Biteau N., Fremaux C., Hebrard S., Menara A., Aigle M., Crouzet M.;
RT   "The complete sequence of a 10.8kb fragment to the right of the chromosome
RT   III centromere of Saccharomyces cerevisiae.";
RL   Yeast 8:61-70(1992).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=1574125; DOI=10.1038/357038a0;
RA   Oliver S.G., van der Aart Q.J.M., Agostoni-Carbone M.L., Aigle M.,
RA   Alberghina L., Alexandraki D., Antoine G., Anwar R., Ballesta J.P.G.,
RA   Benit P., Berben G., Bergantino E., Biteau N., Bolle P.-A.,
RA   Bolotin-Fukuhara M., Brown A., Brown A.J.P., Buhler J.-M., Carcano C.,
RA   Carignani G., Cederberg H., Chanet R., Contreras R., Crouzet M.,
RA   Daignan-Fornier B., Defoor E., Delgado M.D., Demolder J., Doira C.,
RA   Dubois E., Dujon B., Duesterhoeft A., Erdmann D., Esteban M., Fabre F.,
RA   Fairhead C., Faye G., Feldmann H., Fiers W., Francingues-Gaillard M.-C.,
RA   Franco L., Frontali L., Fukuhara H., Fuller L.J., Galland P., Gent M.E.,
RA   Gigot D., Gilliquet V., Glansdorff N., Goffeau A., Grenson M., Grisanti P.,
RA   Grivell L.A., de Haan M., Haasemann M., Hatat D., Hoenicka J.,
RA   Hegemann J.H., Herbert C.J., Hilger F., Hohmann S., Hollenberg C.P.,
RA   Huse K., Iborra F., Indge K.J., Isono K., Jacq C., Jacquet M., James C.M.,
RA   Jauniaux J.-C., Jia Y., Jimenez A., Kelly A., Kleinhans U., Kreisl P.,
RA   Lanfranchi G., Lewis C., van der Linden C.G., Lucchini G.,
RA   Lutzenkirchen K., Maat M.J., Mallet L., Mannhaupt G., Martegani E.,
RA   Mathieu A., Maurer C.T.C., McConnell D., McKee R.A., Messenguy F.,
RA   Mewes H.-W., Molemans F., Montague M.A., Muzi Falconi M., Navas L.,
RA   Newlon C.S., Noone D., Pallier C., Panzeri L., Pearson B.M., Perea J.,
RA   Philippsen P., Pierard A., Planta R.J., Plevani P., Poetsch B., Pohl F.M.,
RA   Purnelle B., Ramezani Rad M., Rasmussen S.W., Raynal A., Remacha M.A.,
RA   Richterich P., Roberts A.B., Rodriguez F., Sanz E.,
RA   Schaaff-Gerstenschlaeger I., Scherens B., Schweitzer B., Shu Y., Skala J.,
RA   Slonimski P.P., Sor F., Soustelle C., Spiegelberg R., Stateva L.I.,
RA   Steensma H.Y., Steiner S., Thierry A., Thireos G., Tzermia M.,
RA   Urrestarazu L.A., Valle G., Vetter I., van Vliet-Reedijk J.C., Voet M.,
RA   Volckaert G., Vreken P., Wang H., Warmington J.R., von Wettstein D.,
RA   Wicksteed B.L., Wilson C., Wurst H., Xu G., Yoshikawa A., Zimmermann F.K.,
RA   Sgouros J.G.;
RT   "The complete DNA sequence of yeast chromosome III.";
RL   Nature 357:38-46(1992).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=24374639; DOI=10.1534/g3.113.008995;
RA   Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA   Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA   Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT   "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL   G3 (Bethesda) 4:389-398(2014).
RN   [4]
RP   SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX   PubMed=14562095; DOI=10.1038/nature02026;
RA   Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W.,
RA   Weissman J.S., O'Shea E.K.;
RT   "Global analysis of protein localization in budding yeast.";
RL   Nature 425:686-691(2003).
RN   [5]
RP   LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX   PubMed=14562106; DOI=10.1038/nature02046;
RA   Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA   O'Shea E.K., Weissman J.S.;
RT   "Global analysis of protein expression in yeast.";
RL   Nature 425:737-741(2003).
RN   [6]
RP   SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RC   STRAIN=ATCC 76625 / YPH499;
RX   PubMed=14576278; DOI=10.1073/pnas.2135385100;
RA   Sickmann A., Reinders J., Wagner Y., Joppich C., Zahedi R.P., Meyer H.E.,
RA   Schoenfisch B., Perschil I., Chacinska A., Guiard B., Rehling P.,
RA   Pfanner N., Meisinger C.;
RT   "The proteome of Saccharomyces cerevisiae mitochondria.";
RL   Proc. Natl. Acad. Sci. U.S.A. 100:13207-13212(2003).
RN   [7]
RP   PALMITOYLATION AT CYS-243.
RX   PubMed=16751107; DOI=10.1016/j.cell.2006.03.042;
RA   Roth A.F., Wan J., Bailey A.O., Sun B., Kuchar J.A., Green W.N.,
RA   Phinney B.S., Yates J.R. III, Davis N.G.;
RT   "Global analysis of protein palmitoylation in yeast.";
RL   Cell 125:1003-1013(2006).
RN   [8]
RP   SUBCELLULAR LOCATION.
RX   PubMed=19064668; DOI=10.1083/jcb.200806035;
RA   Grossmann G., Malinsky J., Stahlschmidt W., Loibl M., Weig-Meckl I.,
RA   Frommer W.B., Opekarova M., Tanner W.;
RT   "Plasma membrane microdomains regulate turnover of transport proteins in
RT   yeast.";
RL   J. Cell Biol. 183:1075-1088(2008).
CC   -!- INTERACTION:
CC       P25349; Q12335: PST2; NbExp=6; IntAct=EBI-21840, EBI-14064;
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:14562095,
CC       ECO:0000269|PubMed:19064668}. Membrane raft
CC       {ECO:0000269|PubMed:19064668}. Mitochondrion
CC       {ECO:0000269|PubMed:14576278}.
CC   -!- MISCELLANEOUS: Present with 14600 molecules/cell in log phase SD
CC       medium. {ECO:0000269|PubMed:14562106}.
CC   -!- SIMILARITY: Belongs to the WrbA family. {ECO:0000305}.
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DR   EMBL; Z11113; CAA77443.1; -; Genomic_DNA.
DR   EMBL; X59720; CAA42341.1; -; Genomic_DNA.
DR   EMBL; BK006937; DAA07483.1; -; Genomic_DNA.
DR   PIR; S26733; S26733.
DR   RefSeq; NP_009930.1; NM_001178717.1.
DR   AlphaFoldDB; P25349; -.
DR   SMR; P25349; -.
DR   BioGRID; 30982; 56.
DR   DIP; DIP-1781N; -.
DR   IntAct; P25349; 23.
DR   MINT; P25349; -.
DR   STRING; 4932.YCR004C; -.
DR   CAZy; AA6; Auxiliary Activities 6.
DR   iPTMnet; P25349; -.
DR   SwissPalm; P25349; -.
DR   MaxQB; P25349; -.
DR   PaxDb; P25349; -.
DR   PRIDE; P25349; -.
DR   EnsemblFungi; YCR004C_mRNA; YCR004C; YCR004C.
DR   GeneID; 850360; -.
DR   KEGG; sce:YCR004C; -.
DR   SGD; S000000597; YCP4.
DR   VEuPathDB; FungiDB:YCR004C; -.
DR   eggNOG; KOG3135; Eukaryota.
DR   GeneTree; ENSGT00940000176381; -.
DR   HOGENOM; CLU_051402_0_0_1; -.
DR   InParanoid; P25349; -.
DR   OMA; SRFGMMA; -.
DR   BioCyc; YEAST:G3O-29323-MON; -.
DR   PRO; PR:P25349; -.
DR   Proteomes; UP000002311; Chromosome III.
DR   RNAct; P25349; protein.
DR   GO; GO:0071944; C:cell periphery; HDA:SGD.
DR   GO; GO:0005737; C:cytoplasm; HDA:SGD.
DR   GO; GO:0045121; C:membrane raft; IEA:UniProtKB-SubCell.
DR   GO; GO:0005739; C:mitochondrion; HDA:SGD.
DR   GO; GO:0005886; C:plasma membrane; HDA:SGD.
DR   GO; GO:0010181; F:FMN binding; IEA:InterPro.
DR   GO; GO:0003955; F:NAD(P)H dehydrogenase (quinone) activity; IEA:InterPro.
DR   Gene3D; 3.40.50.360; -; 1.
DR   InterPro; IPR008254; Flavodoxin/NO_synth.
DR   InterPro; IPR029039; Flavoprotein-like_sf.
DR   InterPro; IPR010089; Flavoprotein_WrbA-like.
DR   InterPro; IPR005025; FMN_Rdtase-like.
DR   Pfam; PF03358; FMN_red; 1.
DR   SUPFAM; SSF52218; SSF52218; 1.
DR   TIGRFAMs; TIGR01755; flav_wrbA; 1.
DR   PROSITE; PS50902; FLAVODOXIN_LIKE; 1.
PE   1: Evidence at protein level;
KW   Cytoplasm; Lipoprotein; Membrane; Methylation; Mitochondrion; Palmitate;
KW   Prenylation; Reference proteome.
FT   CHAIN           1..244
FT                   /note="Flavoprotein-like protein YCP4"
FT                   /id="PRO_0000200768"
FT   PROPEP          245..247
FT                   /note="Removed in mature form"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000366191"
FT   DOMAIN          4..193
FT                   /note="Flavodoxin-like"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00088"
FT   REGION          204..247
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        204..219
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         244
FT                   /note="Cysteine methyl ester"
FT                   /evidence="ECO:0000255"
FT   LIPID           243
FT                   /note="S-palmitoyl cysteine"
FT                   /evidence="ECO:0000305|PubMed:16751107"
FT   LIPID           244
FT                   /note="S-farnesyl cysteine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   247 AA;  26350 MW;  92AAD81C0691DE5D CRC64;
     MVKIAIITYS TYGHIDVLAQ AVKKGVEAAG GKADIYRVEE TLPDEVLTKM NAPQKPEDIP
     VATEKTLLEY DAFLFGVPTR FGNLPAQWSA FWDKTGGLWA KGSLNGKAAG IFVSTSSYGG
     GQESTVKACL SYLAHHGIIF LPLGYKNSFA ELASIEEVHG GSPWGAGTLA GPDGSRTASP
     LELRIAEIQG KTFYETAKKL FPAKEAKPST EKKTTTSDAA KRQTKPAAAT TAEKKEDKGL
     LSCCTVM
 
 
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