YCP7_YEAST
ID YCP7_YEAST Reviewed; 239 AA.
AC P25354; D6VR16; Q70DH1; Q70DH4; Q70DH6;
DT 01-MAY-1992, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1992, sequence version 1.
DT 03-AUG-2022, entry version 146.
DE RecName: Full=DUP240 protein YCR007C;
GN OrderedLocusNames=YCR007C; ORFNames=YCR045, YCR7C;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS LYS-2; THR-42 AND ILE-215.
RC STRAIN=CLIB 219, CLIB 382, CLIB 388, CLIB 410, CLIB 413, CLIB 556,
RC CLIB 630, CLIB 95, K1, R12, R13, Sigma 1278B, YIIc12, and YIIc17;
RX PubMed=15087486; DOI=10.1093/nar/gkh529;
RA Leh-Louis V., Wirth B., Despons L., Wain-Hobson S., Potier S.,
RA Souciet J.-L.;
RT "Differential evolution of the Saccharomyces cerevisiae DUP240 paralogs and
RT implication of recombination in phylogeny.";
RL Nucleic Acids Res. 32:2069-2078(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=1580102; DOI=10.1002/yea.320080107;
RA Biteau N., Fremaux C., Hebrard S., Menara A., Aigle M., Crouzet M.;
RT "The complete sequence of a 10.8kb fragment to the right of the chromosome
RT III centromere of Saccharomyces cerevisiae.";
RL Yeast 8:61-70(1992).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=1574125; DOI=10.1038/357038a0;
RA Oliver S.G., van der Aart Q.J.M., Agostoni-Carbone M.L., Aigle M.,
RA Alberghina L., Alexandraki D., Antoine G., Anwar R., Ballesta J.P.G.,
RA Benit P., Berben G., Bergantino E., Biteau N., Bolle P.-A.,
RA Bolotin-Fukuhara M., Brown A., Brown A.J.P., Buhler J.-M., Carcano C.,
RA Carignani G., Cederberg H., Chanet R., Contreras R., Crouzet M.,
RA Daignan-Fornier B., Defoor E., Delgado M.D., Demolder J., Doira C.,
RA Dubois E., Dujon B., Duesterhoeft A., Erdmann D., Esteban M., Fabre F.,
RA Fairhead C., Faye G., Feldmann H., Fiers W., Francingues-Gaillard M.-C.,
RA Franco L., Frontali L., Fukuhara H., Fuller L.J., Galland P., Gent M.E.,
RA Gigot D., Gilliquet V., Glansdorff N., Goffeau A., Grenson M., Grisanti P.,
RA Grivell L.A., de Haan M., Haasemann M., Hatat D., Hoenicka J.,
RA Hegemann J.H., Herbert C.J., Hilger F., Hohmann S., Hollenberg C.P.,
RA Huse K., Iborra F., Indge K.J., Isono K., Jacq C., Jacquet M., James C.M.,
RA Jauniaux J.-C., Jia Y., Jimenez A., Kelly A., Kleinhans U., Kreisl P.,
RA Lanfranchi G., Lewis C., van der Linden C.G., Lucchini G.,
RA Lutzenkirchen K., Maat M.J., Mallet L., Mannhaupt G., Martegani E.,
RA Mathieu A., Maurer C.T.C., McConnell D., McKee R.A., Messenguy F.,
RA Mewes H.-W., Molemans F., Montague M.A., Muzi Falconi M., Navas L.,
RA Newlon C.S., Noone D., Pallier C., Panzeri L., Pearson B.M., Perea J.,
RA Philippsen P., Pierard A., Planta R.J., Plevani P., Poetsch B., Pohl F.M.,
RA Purnelle B., Ramezani Rad M., Rasmussen S.W., Raynal A., Remacha M.A.,
RA Richterich P., Roberts A.B., Rodriguez F., Sanz E.,
RA Schaaff-Gerstenschlaeger I., Scherens B., Schweitzer B., Shu Y., Skala J.,
RA Slonimski P.P., Sor F., Soustelle C., Spiegelberg R., Stateva L.I.,
RA Steensma H.Y., Steiner S., Thierry A., Thireos G., Tzermia M.,
RA Urrestarazu L.A., Valle G., Vetter I., van Vliet-Reedijk J.C., Voet M.,
RA Volckaert G., Vreken P., Wang H., Warmington J.R., von Wettstein D.,
RA Wicksteed B.L., Wilson C., Wurst H., Xu G., Yoshikawa A., Zimmermann F.K.,
RA Sgouros J.G.;
RT "The complete DNA sequence of yeast chromosome III.";
RL Nature 357:38-46(1992).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [5]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=17322287; DOI=10.1101/gr.6037607;
RA Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F.,
RA Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J.,
RA Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J.,
RA Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D.,
RA LaBaer J.;
RT "Approaching a complete repository of sequence-verified protein-encoding
RT clones for Saccharomyces cerevisiae.";
RL Genome Res. 17:536-543(2007).
RN [6]
RP INTERACTION WITH MEC3 AND ULP1.
RX PubMed=11283351; DOI=10.1073/pnas.061034498;
RA Ito T., Chiba T., Ozawa R., Yoshida M., Hattori M., Sakaki Y.;
RT "A comprehensive two-hybrid analysis to explore the yeast protein
RT interactome.";
RL Proc. Natl. Acad. Sci. U.S.A. 98:4569-4574(2001).
RN [7]
RP DISRUPTION PHENOTYPE.
RX PubMed=12101299; DOI=10.1099/00221287-148-7-2111;
RA Poirey R., Despons L., Leh V., Lafuente M.-J., Potier S., Souciet J.-L.,
RA Jauniaux J.-C.;
RT "Functional analysis of the Saccharomyces cerevisiae DUP240 multigene
RT family reveals membrane-associated proteins that are not essential for cell
RT viability.";
RL Microbiology 148:2111-2123(2002).
RN [8]
RP TOPOLOGY [LARGE SCALE ANALYSIS].
RC STRAIN=ATCC 208353 / W303-1A;
RX PubMed=16847258; DOI=10.1073/pnas.0604075103;
RA Kim H., Melen K., Oesterberg M., von Heijne G.;
RT "A global topology map of the Saccharomyces cerevisiae membrane proteome.";
RL Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006).
CC -!- SUBUNIT: Interacts according to large scale protein interaction studies
CC with MEC3 and ULP1. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- DISRUPTION PHENOTYPE: Members of the DUP240 multigene family are
CC specific to S.cerevisiae sensu strictu. Cells lacking all 10 DUP240
CC proteins show no obvious alterations in mating, sporulation and cell
CC growth. {ECO:0000269|PubMed:12101299}.
CC -!- SIMILARITY: Belongs to the DUP/COS family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AJ585549; CAE52069.1; -; Genomic_DNA.
DR EMBL; AJ585550; CAE52070.1; -; Genomic_DNA.
DR EMBL; AJ585551; CAE52071.1; -; Genomic_DNA.
DR EMBL; AJ585552; CAE52072.1; -; Genomic_DNA.
DR EMBL; AJ585553; CAE52073.1; -; Genomic_DNA.
DR EMBL; AJ585554; CAE52074.1; -; Genomic_DNA.
DR EMBL; AJ585555; CAE52075.1; -; Genomic_DNA.
DR EMBL; AJ585556; CAE52076.1; -; Genomic_DNA.
DR EMBL; AJ585557; CAE52077.1; -; Genomic_DNA.
DR EMBL; AJ585558; CAE52078.1; -; Genomic_DNA.
DR EMBL; AJ585559; CAE52079.1; -; Genomic_DNA.
DR EMBL; AJ585560; CAE52080.1; -; Genomic_DNA.
DR EMBL; AJ585561; CAE52081.1; -; Genomic_DNA.
DR EMBL; AJ585562; CAE52082.1; -; Genomic_DNA.
DR EMBL; AJ585563; CAE52083.1; -; Genomic_DNA.
DR EMBL; AJ585564; CAE52084.1; -; Genomic_DNA.
DR EMBL; Z11114; CAA77446.1; -; Genomic_DNA.
DR EMBL; X59720; CAA42324.1; -; Genomic_DNA.
DR EMBL; AY558149; AAS56475.1; -; Genomic_DNA.
DR EMBL; BK006937; DAA07485.1; -; Genomic_DNA.
DR PIR; S20184; S20184.
DR RefSeq; NP_009933.1; NM_001178720.1.
DR AlphaFoldDB; P25354; -.
DR BioGRID; 30985; 62.
DR DIP; DIP-4043N; -.
DR IntAct; P25354; 8.
DR MINT; P25354; -.
DR STRING; 4932.YCR007C; -.
DR MaxQB; P25354; -.
DR PaxDb; P25354; -.
DR PRIDE; P25354; -.
DR EnsemblFungi; YCR007C_mRNA; YCR007C; YCR007C.
DR GeneID; 850364; -.
DR KEGG; sce:YCR007C; -.
DR SGD; S000000600; YCR007C.
DR VEuPathDB; FungiDB:YCR007C; -.
DR eggNOG; ENOG502SSNW; Eukaryota.
DR GeneTree; ENSGT00940000176285; -.
DR HOGENOM; CLU_081384_0_1_1; -.
DR InParanoid; P25354; -.
DR OMA; QADICDW; -.
DR BioCyc; YEAST:G3O-29324-MON; -.
DR PRO; PR:P25354; -.
DR Proteomes; UP000002311; Chromosome III.
DR RNAct; P25354; protein.
DR GO; GO:0071944; C:cell periphery; HDA:SGD.
DR GO; GO:0000324; C:fungal-type vacuole; HDA:SGD.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR001142; DUP/COS.
DR Pfam; PF00674; DUP; 1.
PE 1: Evidence at protein level;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..239
FT /note="DUP240 protein YCR007C"
FT /id="PRO_0000207531"
FT TOPO_DOM 1..54
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 55..75
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 76..79
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 80..104
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 105..239
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT VARIANT 2
FT /note="Q -> K (in strain: CLIB 219)"
FT /evidence="ECO:0000269|PubMed:15087486"
FT VARIANT 42
FT /note="M -> T (in strain: CLIB 219, CLIB 410, CLIB 413,
FT CLIB 630 haplotype Ha1, K1, YIIc12 haplotype Ha2 and CLIB
FT 382)"
FT /evidence="ECO:0000269|PubMed:15087486"
FT VARIANT 215
FT /note="V -> I (in strain: CLIB 630)"
FT /evidence="ECO:0000269|PubMed:15087486"
SQ SEQUENCE 239 AA; 27564 MW; 8A8586E1AA4E4ED7 CRC64;
MQPHLDNNSN NDDVKLDTLG EQNVLSSAEN ITLPEDTFKS YMTYLLYEMA HYKPMIFSFL
ALSVSILIVV IFHNVKACDV VFGFSIFVTS ILFLSTLIPF NVYISDEGFR IKLLLEVITH
RPAVKGKEWR AITDNMNQYL LDNGLWSTRY YFYSSERCYK FFRFLVKEKP PGVNVNSSVK
DATSTQIDAP ANEASNEVIK CFSFSSDPIF EAYFVKAVEV EKQAQQEYWR KQYPDADIP
