YCR41_YEAST
ID YCR41_YEAST Reviewed; 110 AA.
AC P37265; A0A0I9RJ66;
DT 01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1994, sequence version 1.
DT 25-MAY-2022, entry version 97.
DE RecName: Full=Uncharacterized protein YCR041W;
GN OrderedLocusNames=YCR041W {ECO:0000312|SGD:S000000637}; ORFNames=YCR41W;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=1574125; DOI=10.1038/357038a0;
RA Oliver S.G., van der Aart Q.J.M., Agostoni-Carbone M.L., Aigle M.,
RA Alberghina L., Alexandraki D., Antoine G., Anwar R., Ballesta J.P.G.,
RA Benit P., Berben G., Bergantino E., Biteau N., Bolle P.-A.,
RA Bolotin-Fukuhara M., Brown A., Brown A.J.P., Buhler J.-M., Carcano C.,
RA Carignani G., Cederberg H., Chanet R., Contreras R., Crouzet M.,
RA Daignan-Fornier B., Defoor E., Delgado M.D., Demolder J., Doira C.,
RA Dubois E., Dujon B., Duesterhoeft A., Erdmann D., Esteban M., Fabre F.,
RA Fairhead C., Faye G., Feldmann H., Fiers W., Francingues-Gaillard M.-C.,
RA Franco L., Frontali L., Fukuhara H., Fuller L.J., Galland P., Gent M.E.,
RA Gigot D., Gilliquet V., Glansdorff N., Goffeau A., Grenson M., Grisanti P.,
RA Grivell L.A., de Haan M., Haasemann M., Hatat D., Hoenicka J.,
RA Hegemann J.H., Herbert C.J., Hilger F., Hohmann S., Hollenberg C.P.,
RA Huse K., Iborra F., Indge K.J., Isono K., Jacq C., Jacquet M., James C.M.,
RA Jauniaux J.-C., Jia Y., Jimenez A., Kelly A., Kleinhans U., Kreisl P.,
RA Lanfranchi G., Lewis C., van der Linden C.G., Lucchini G.,
RA Lutzenkirchen K., Maat M.J., Mallet L., Mannhaupt G., Martegani E.,
RA Mathieu A., Maurer C.T.C., McConnell D., McKee R.A., Messenguy F.,
RA Mewes H.-W., Molemans F., Montague M.A., Muzi Falconi M., Navas L.,
RA Newlon C.S., Noone D., Pallier C., Panzeri L., Pearson B.M., Perea J.,
RA Philippsen P., Pierard A., Planta R.J., Plevani P., Poetsch B., Pohl F.M.,
RA Purnelle B., Ramezani Rad M., Rasmussen S.W., Raynal A., Remacha M.A.,
RA Richterich P., Roberts A.B., Rodriguez F., Sanz E.,
RA Schaaff-Gerstenschlaeger I., Scherens B., Schweitzer B., Shu Y., Skala J.,
RA Slonimski P.P., Sor F., Soustelle C., Spiegelberg R., Stateva L.I.,
RA Steensma H.Y., Steiner S., Thierry A., Thireos G., Tzermia M.,
RA Urrestarazu L.A., Valle G., Vetter I., van Vliet-Reedijk J.C., Voet M.,
RA Volckaert G., Vreken P., Wang H., Warmington J.R., von Wettstein D.,
RA Wicksteed B.L., Wilson C., Wurst H., Xu G., Yoshikawa A., Zimmermann F.K.,
RA Sgouros J.G.;
RT "The complete DNA sequence of yeast chromosome III.";
RL Nature 357:38-46(1992).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=17322287; DOI=10.1101/gr.6037607;
RA Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F.,
RA Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J.,
RA Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J.,
RA Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D.,
RA LaBaer J.;
RT "Approaching a complete repository of sequence-verified protein-encoding
RT clones for Saccharomyces cerevisiae.";
RL Genome Res. 17:536-543(2007).
RN [4]
RP FUNCTION.
RX PubMed=25454064; DOI=10.1016/j.jbiosc.2014.10.006;
RA Sasano Y., Yamagishi K., Tanikawa M., Nakazawa T., Sugiyama M., Kaneko Y.,
RA Harashima S.;
RT "Stabilization of mini-chromosome segregation during mitotic growth by
RT overexpression of YCR041W and its application to chromosome engineering in
RT Saccharomyces cerevisiae.";
RL J. Biosci. Bioeng. 119:526-531(2015).
CC -!- FUNCTION: May play a role in proper chromosome segregation. Suppresses
CC the high-frequency loss of mini-chromosomes when overexpressed, and
CC this suppression is completely dependent on silencing protein SIR4.
CC {ECO:0000269|PubMed:17322287}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane
CC protein {ECO:0000255}.
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DR EMBL; X59720; CAA42289.1; -; Genomic_DNA.
DR EMBL; AY693251; AAT93270.1; -; Genomic_DNA.
DR EMBL; BK006937; DAA64811.1; -; Genomic_DNA.
DR PIR; S19454; S19454.
DR RefSeq; NP_001297596.1; NM_001310667.1.
DR AlphaFoldDB; P37265; -.
DR DIP; DIP-4992N; -.
DR IntAct; P37265; 5.
DR STRING; 4932.YCR041W; -.
DR PaxDb; P37265; -.
DR EnsemblFungi; YCR041W_mRNA; YCR041W; YCR041W.
DR GeneID; 850408; -.
DR KEGG; sce:YCR041W; -.
DR SGD; S000000637; YCR041W.
DR VEuPathDB; FungiDB:YCR041W; -.
DR GeneTree; ENSGT00940000179575; -.
DR HOGENOM; CLU_164955_0_0_1; -.
DR PRO; PR:P37265; -.
DR Proteomes; UP000002311; Chromosome III.
DR RNAct; P37265; protein.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0007059; P:chromosome segregation; IEA:UniProtKB-KW.
PE 3: Inferred from homology;
KW Chromosome partition; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..110
FT /note="Uncharacterized protein YCR041W"
FT /id="PRO_0000202567"
FT TRANSMEM 32..52
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 57..77
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 90..110
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 110 AA; 12887 MW; 639A5B3C445C74D0 CRC64;
MLKYVVTDIG KMCLYIWPYR VWSWRRLFIF RVLNVVSIAI LFETPHRLAL VPNVCLYTHM
AIPLSTCLFC LCLCICIKYD ITQTQANNQF LASFFVLILT INDLDVTFVI
