YCRA_SCHPO
ID YCRA_SCHPO Reviewed; 382 AA.
AC O74497;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1998, sequence version 1.
DT 25-MAY-2022, entry version 110.
DE RecName: Full=SPRY domain-containing protein C285.10c;
GN ORFNames=SPCC285.10c;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16823372}. Membrane
CC {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
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DR EMBL; CU329672; CAA20849.1; -; Genomic_DNA.
DR PIR; T41256; T41256.
DR RefSeq; NP_588338.1; NM_001023329.2.
DR AlphaFoldDB; O74497; -.
DR SMR; O74497; -.
DR BioGRID; 275783; 26.
DR STRING; 4896.SPCC285.10c.1; -.
DR MaxQB; O74497; -.
DR PaxDb; O74497; -.
DR PRIDE; O74497; -.
DR EnsemblFungi; SPCC285.10c.1; SPCC285.10c.1:pep; SPCC285.10c.
DR GeneID; 2539213; -.
DR KEGG; spo:SPCC285.10c; -.
DR PomBase; SPCC285.10c; -.
DR VEuPathDB; FungiDB:SPCC285.10c; -.
DR eggNOG; KOG1477; Eukaryota.
DR HOGENOM; CLU_016552_2_0_1; -.
DR InParanoid; O74497; -.
DR OMA; CVLFIRR; -.
DR PhylomeDB; O74497; -.
DR PRO; PR:O74497; -.
DR Proteomes; UP000002485; Chromosome III.
DR GO; GO:0005737; C:cytoplasm; HDA:PomBase.
DR GO; GO:0005783; C:endoplasmic reticulum; ISO:PomBase.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; IBA:GO_Central.
DR GO; GO:0043328; P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway; ISO:PomBase.
DR CDD; cd12910; SPRY_SSH4_like; 1.
DR Gene3D; 2.60.120.920; -; 1.
DR InterPro; IPR001870; B30.2/SPRY.
DR InterPro; IPR043136; B30.2/SPRY_sf.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR003877; SPRY_dom.
DR InterPro; IPR035780; SPRY_Ssh4-like.
DR Pfam; PF00622; SPRY; 1.
DR SMART; SM00449; SPRY; 1.
DR SUPFAM; SSF49899; SSF49899; 1.
DR PROSITE; PS50188; B302_SPRY; 1.
PE 4: Predicted;
KW Cytoplasm; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..382
FT /note="SPRY domain-containing protein C285.10c"
FT /id="PRO_0000314094"
FT TRANSMEM 21..41
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 79..284
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00548"
FT REGION 304..382
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 305..375
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 382 AA; 42870 MW; 1EE7C2FD7B8529A7 CRC64;
MHPDQIRQLR LQESSNTHPN LAILFIFIAL AAVIVLLICL LSVILLLRYT RHGRILLKNT
NPGELDDEAL ENEHIDEEGF SLLDDMGKER YLQAREFELN SMKSNVNTDA KLLDFLQVQE
KGVLAWHFIP NQEYNCYVKN KTELSFLGNE ECCMQTNLPL QRINEVYYFE VKLLDVPIDT
LVSIGLATKP YPPFRLPGWN FWSTAYVSDG TRRSNSPFTG KPYSSFYQQG DVIGVGYKPK
CNRIFFTRNG RRCAELPCTY RNLYPTVGAI GPCTLHVNLG QAGYVFIEAN IKKWRLAPAV
GSLAPPPSYS TSQPTISWDA ASESSAGTTT QGDTNRPDKS KNRSPPINFD GTSYDAAGNV
FSPSSSNNQA YQMHSMPATD EV
