CB016_HUMAN
ID CB016_HUMAN Reviewed; 1984 AA.
AC Q68DN1; B9EIQ4; Q53S01; Q8ND64; Q9H088;
DT 03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT 18-MAY-2010, sequence version 3.
DT 03-AUG-2022, entry version 118.
DE RecName: Full=Uncharacterized protein C2orf16;
GN Name=C2orf16;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT PRO-1665.
RC TISSUE=Testis;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1031-1984, AND VARIANT PRO-1665.
RC TISSUE=Testis;
RX PubMed=11230166; DOI=10.1101/gr.gr1547r;
RA Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S.,
RA Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J.,
RA Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W.,
RA Ottenwaelder B., Obermaier B., Tampe J., Heubner D., Wambutt R., Korn B.,
RA Klein M., Poustka A.;
RT "Towards a catalog of human genes and proteins: sequencing and analysis of
RT 500 novel complete protein coding human cDNAs.";
RL Genome Res. 11:422-435(2001).
CC -!- DOMAIN: The P-S-E-R-S-H-H-S repeats give rise to an antiparallel beta-
CC structure.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAX93198.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AL834384; CAD39047.1; -; mRNA.
DR EMBL; CR749335; CAH18189.1; -; mRNA.
DR EMBL; AC074091; AAX93198.1; ALT_INIT; Genomic_DNA.
DR EMBL; BC140828; AAI40829.1; -; mRNA.
DR EMBL; AL136898; CAB66832.2; -; mRNA.
DR RefSeq; NP_115642.3; NM_032266.3.
DR AlphaFoldDB; Q68DN1; -.
DR BioGRID; 123960; 2.
DR IntAct; Q68DN1; 1.
DR STRING; 9606.ENSP00000386190; -.
DR iPTMnet; Q68DN1; -.
DR PhosphoSitePlus; Q68DN1; -.
DR BioMuta; C2orf16; -.
DR DMDM; 296439423; -.
DR EPD; Q68DN1; -.
DR jPOST; Q68DN1; -.
DR MassIVE; Q68DN1; -.
DR PaxDb; Q68DN1; -.
DR PeptideAtlas; Q68DN1; -.
DR PRIDE; Q68DN1; -.
DR ProteomicsDB; 66093; -.
DR Antibodypedia; 62791; 41 antibodies from 7 providers.
DR DNASU; 84226; -.
DR GeneID; 84226; -.
DR KEGG; hsa:84226; -.
DR UCSC; uc002rkz.5; human.
DR CTD; 84226; -.
DR DisGeNET; 84226; -.
DR GeneCards; C2orf16; -.
DR HGNC; HGNC:25275; C2orf16.
DR HPA; ENSG00000221843; Tissue enriched (testis).
DR neXtProt; NX_Q68DN1; -.
DR PharmGKB; PA134977296; -.
DR VEuPathDB; HostDB:ENSG00000221843; -.
DR eggNOG; ENOG502S9JK; Eukaryota.
DR HOGENOM; CLU_002788_0_0_1; -.
DR InParanoid; Q68DN1; -.
DR OrthoDB; 402at2759; -.
DR PhylomeDB; Q68DN1; -.
DR TreeFam; TF339785; -.
DR PathwayCommons; Q68DN1; -.
DR SignaLink; Q68DN1; -.
DR BioGRID-ORCS; 84226; 8 hits in 1038 CRISPR screens.
DR GenomeRNAi; 84226; -.
DR Pharos; Q68DN1; Tdark.
DR PRO; PR:Q68DN1; -.
DR Proteomes; UP000005640; Chromosome 2.
DR RNAct; Q68DN1; protein.
DR Bgee; ENSG00000221843; Expressed in sperm and 103 other tissues.
DR ExpressionAtlas; Q68DN1; baseline and differential.
DR Genevisible; Q68DN1; HS.
DR GO; GO:0070062; C:extracellular exosome; HDA:UniProtKB.
DR GO; GO:0005634; C:nucleus; HDA:UniProtKB.
PE 2: Evidence at transcript level;
KW Reference proteome; Repeat.
FT CHAIN 1..1984
FT /note="Uncharacterized protein C2orf16"
FT /id="PRO_0000281907"
FT REPEAT 1593..1600
FT /note="1"
FT REPEAT 1601..1608
FT /note="2"
FT REPEAT 1609..1616
FT /note="3"
FT REPEAT 1641..1648
FT /note="4"
FT REPEAT 1649..1656
FT /note="5"
FT REPEAT 1657..1664
FT /note="6"
FT REPEAT 1681..1688
FT /note="7"
FT REPEAT 1689..1696
FT /note="8"
FT REPEAT 1697..1704
FT /note="9"
FT REPEAT 1705..1712
FT /note="10"
FT REPEAT 1713..1720
FT /note="11"
FT REPEAT 1721..1728
FT /note="12"
FT REPEAT 1729..1736
FT /note="13"
FT REPEAT 1737..1744
FT /note="14"
FT REPEAT 1745..1752
FT /note="15"
FT REPEAT 1753..1760
FT /note="16"
FT REPEAT 1761..1768
FT /note="17"
FT REPEAT 1769..1776
FT /note="18"
FT REPEAT 1777..1784
FT /note="19"
FT REPEAT 1785..1792
FT /note="20"
FT REPEAT 1793..1800
FT /note="21"
FT REPEAT 1801..1808
FT /note="22"
FT REPEAT 1848..1855
FT /note="23"
FT REPEAT 1864..1871
FT /note="24"
FT REPEAT 1880..1887
FT /note="25"
FT REPEAT 1921..1928
FT /note="26"
FT REPEAT 1929..1935
FT /note="27"
FT REGION 448..467
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1045..1067
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1181..1287
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1326..1346
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1439..1984
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1593..1935
FT /note="27 X 8 AA approximate tandem repeat of P-S-E-R-S-H-
FT H-S"
FT COMPBIAS 449..463
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1198..1226
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1237..1251
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1267..1287
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1327..1341
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1460..1480
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1495..1509
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1536..1586
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1590..1620
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1644..1703
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1704..1723
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1724..1873
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1874..1894
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1895..1916
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1956..1970
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 357
FT /note="R -> G (in dbSNP:rs17006143)"
FT /id="VAR_031313"
FT VARIANT 505
FT /note="D -> V (in dbSNP:rs13410886)"
FT /id="VAR_031314"
FT VARIANT 655
FT /note="T -> S (in dbSNP:rs1919125)"
FT /id="VAR_031315"
FT VARIANT 660
FT /note="A -> E (in dbSNP:rs1919126)"
FT /id="VAR_031316"
FT VARIANT 685
FT /note="V -> A (in dbSNP:rs1919127)"
FT /id="VAR_031317"
FT VARIANT 767
FT /note="I -> T (in dbSNP:rs13416968)"
FT /id="VAR_031318"
FT VARIANT 774
FT /note="I -> V (in dbSNP:rs1919128)"
FT /id="VAR_031319"
FT VARIANT 1500
FT /note="S -> F (in dbSNP:rs12618071)"
FT /id="VAR_031320"
FT VARIANT 1559
FT /note="H -> Y (in dbSNP:rs13392197)"
FT /id="VAR_031321"
FT VARIANT 1613
FT /note="N -> S (in dbSNP:rs13031957)"
FT /id="VAR_031322"
FT VARIANT 1665
FT /note="S -> P (in dbSNP:rs28381983)"
FT /evidence="ECO:0000269|PubMed:11230166,
FT ECO:0000269|PubMed:17974005"
FT /id="VAR_031323"
FT CONFLICT 613
FT /note="Q -> L (in Ref. 1; CAH18189)"
FT /evidence="ECO:0000305"
FT CONFLICT 1493
FT /note="N -> D (in Ref. 1; CAH18189)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1984 AA; 224321 MW; D1232B8DADB28773 CRC64;
MELTPGAQQQ GINYQELTSG WQDVKSMMLV PEPTRKFPSG PLLTSVRFSN LSPESQQQDV
KSLEFTVEPK LQSVKHVKLS SVSLQQTIKS VELAPGSLPQ RVKYGEQTPR TNYQIMESSE
LIPRPGHQFA KYAEMIPQPK YQIPKSANLI SIPIYHATES SEMAQGLAYK GIDTVEKSVG
LTPKLTGRAK ESLGMLLQPD LQVPKFVDLT PMVRDQGSKF LGLTPEKSYQ ILETMELLSQ
SRPRVKDVGE LYMKPLQQTV EYEGITPELK HYFTEAMGLT AEARIQANEF FGMTPKPTSQ
ATGFAERSPR LCPQNLECVE VISEKRLQGE ESVVLIPKSL HHVPDSASGM TPGLGHRVPE
SVELTSKSGV QVEKTLQLTP KPQHHVGSPG IISGLGHQVP ESVNLTCKQW LQMEESLEVP
LKQTSQVIGH EESVELTSEA RQHREVSMGL TKSKNQSMKS PGTTPGPLGR IVEFMRISPE
PLDQVTESAR TQLQVAQSEE VILIDVPKVV QSVKVTPGPP FQIVKSVTIP RPTPQMVEYI
ELTPKLQYVR PSEHHTGPCL QDVKSTKLIT KPKHQILETV ELTGFQIVKT MLIPGPSLQI
VKSEELAPGP IPQVVEPIGV ALESGIEAIN CVDLLPRPHL QELIVPAELT PSPCTQVKSA
ELTSPQTSPF EEHTILTHKQ GLQAVKSTVI KTEPPKVMET EDLNLGHVCQ NRDCQKLTSE
ELQVGTDFSR FLQSSSTTLI SSSVRTASEL GGLWDSGIQE VSRALDIKNP GTDILQPEET
YIDPTMIQSL TFPLALHNQS SDKTANIVEN PCPEILGVDV ISKETTKRKQ MEELENSLQR
HLPQSWRSRS RTFQAESGVQ KGLIKSFPGR QHNVWESHAW RQRLPRKYLS TMLMLGNILG
TTMERKLCSQ TSLAERATAD TCQSIQNLFG IPAELMEPSQ SLPEKGPVTI SQPSVVKNYI
QRHTFYHGHK KRMALRIWTR GSTSSIIQQY SGTRVRIKKT NSTFNGISQE VIQHMPVSCA
GGQLPVLVKS ESSLSIFYDR EDLVPMEESE DSQSDSQTRI SESQHSLKPN YLSQAKTDFS
EQFQLLEDLQ LKIAAKLLRS QIPPDVPPPL ASGLVLKYPI CLQCGRCSGL NCHHKLQTTS
GPYLLIYPQL HLVRTPEGHG EVRLHLGFRL RIGKRSQISK YRERDRPVIR RSPISPSQRK
AKIYTQASKS PTSTIDLQSG PSQSPAPVQV YIRRGQRSRP DLVEKTKTRA PGHYEFTQVH
NLPESDSEST QNEKRAKVRT KKTSDSKYPM KRITKRLRKH RKFYTNSRTT IESPSRELAA
HLRRKRIGAT QTSTASLKRQ PKKPSQPKFM QLLFQSLKRA FQTAHRVIAS VGRKPVDGTR
PDNLWASKNY YPKQNARDYC LPSSIKRDKR SADKLTPAGS TIKQEDILWG GTVQCRSAQQ
PRRAYSFQPR PLRLPKPTDS QSGIAFQTAS VGQPLRTVQK DSSSRSKKNF YRNETSSQES
KNLSTPGTRV QARGRILPGS PVKRTWHRHL KDKLTHKEHN HPSFYRERTP RGPSERTRHN
PSWRNHRSPS ERSQRSSLER RHHSPSQRSH CSPSRKNHSS PSERSWRSPS QRNHCSPPER
SCHSLSERGL HSPSQRSHRG PSQRRHHSPS ERSHRSPSER SHRSSSERRH RSPSQRSHRG
PSERSHCSPS ERRHRSPSQR SHRGPSERRH HSPSKRSHRS PARRSHRSPS ERSHHSPSER
SHHSPSERRH HSPSERSHCS PSERSHCSPS ERRHRSPSER RHHSPSEKSH HSPSERSHHS
PSERRRHSPL ERSRHSLLER SHRSPSERRS HRSFERSHRR ISERSHSPSE KSHLSPLERS
RCSPSERRGH SSSGKTCHSP SERSHRSPSG MRQGRTSERS HRSSCERTRH SPSEMRPGRP
SGRNHCSPSE RSRRSPLKEG LKYSFPGERP SHSLSRDFKN QTTLLGTTHK NPKAGQVWRP
EATR
