ID   YCVC_SCHPO              Reviewed;         238 AA.
AC   O74551;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   25-MAY-2022, entry version 97.
DE   RecName: Full=Uncharacterized protein C777.12c;
DE   Flags: Precursor;
GN   ORFNames=SPCC777.12c;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
RN   [2]
RP   SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX   PubMed=16823372; DOI=10.1038/nbt1222;
RA   Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA   Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA   Yoshida M.;
RT   "ORFeome cloning and global analysis of protein localization in the fission
RT   yeast Schizosaccharomyces pombe.";
RL   Nat. Biotechnol. 24:841-847(2006).
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000269|PubMed:16823372}; Single-pass membrane protein
CC       {ECO:0000269|PubMed:16823372}.
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DR   EMBL; CU329672; CAA20716.1; -; Genomic_DNA.
DR   PIR; T11718; T11718.
DR   RefSeq; NP_588258.1; NM_001023248.2.
DR   AlphaFoldDB; O74551; -.
DR   SMR; O74551; -.
DR   BioGRID; 275458; 1.
DR   STRING; 4896.SPCC777.12c.1; -.
DR   MaxQB; O74551; -.
DR   PaxDb; O74551; -.
DR   EnsemblFungi; SPCC777.12c.1; SPCC777.12c.1:pep; SPCC777.12c.
DR   GeneID; 2538879; -.
DR   KEGG; spo:SPCC777.12c; -.
DR   PomBase; SPCC777.12c; -.
DR   VEuPathDB; FungiDB:SPCC777.12c; -.
DR   HOGENOM; CLU_1176009_0_0_1; -.
DR   InParanoid; O74551; -.
DR   OMA; YFINGAN; -.
DR   PRO; PR:O74551; -.
DR   Proteomes; UP000002485; Chromosome III.
DR   GO; GO:0005783; C:endoplasmic reticulum; HDA:PomBase.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0015036; F:disulfide oxidoreductase activity; ISS:PomBase.
DR   GO; GO:0034975; P:protein folding in endoplasmic reticulum; IC:PomBase.
DR   GO; GO:0034976; P:response to endoplasmic reticulum stress; ISS:PomBase.
DR   InterPro; IPR036249; Thioredoxin-like_sf.
DR   SUPFAM; SSF52833; SSF52833; 1.
PE   3: Inferred from homology;
KW   Endoplasmic reticulum; Membrane; Reference proteome; Signal; Transmembrane;
KW   Transmembrane helix.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   CHAIN           20..238
FT                   /note="Uncharacterized protein C777.12c"
FT                   /id="PRO_0000303997"
FT   TOPO_DOM        20..197
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        198..216
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        217..238
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   238 AA;  26889 MW;  A6C572B91512F92A CRC64;
     MKINLFFVFL FELLHFVAAY SCEGDESAAI EAMNVLQVPY EKYNTDPVCA FDNSTVVELS
     DKTWDHVIES GKWFVQLTAE GCANCTLGEL LFNDLSHAFH EKYPDVHFAR VYLSSSLELS
     VRLLISRIPS YYFIDNQNFY RVSPQVLPKN KAIALYEKDG FKSMKKEQGF FSVNGPLKSF
     YWVFGKALAL YGHLSQKYTP LGMNVAIFGI SAYIMYRSSK KAKQKQAAAA AAAAAKKK