CB042_HUMAN
ID CB042_HUMAN Reviewed; 574 AA.
AC Q9NWW7; D6W5G3; Q9H629;
DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 143.
DE RecName: Full=Uncharacterized protein C2orf42;
GN Name=C2orf42;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=11230166; DOI=10.1101/gr.gr1547r;
RA Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S.,
RA Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J.,
RA Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W.,
RA Ottenwaelder B., Obermaier B., Tampe J., Heubner D., Wambutt R., Korn B.,
RA Klein M., Poustka A.;
RT "Towards a catalog of human genes and proteins: sequencing and analysis of
RT 500 novel complete protein coding human cDNAs.";
RL Genome Res. 11:422-435(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Signet-ring cell carcinoma, and Small intestine;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Placenta, and Skin;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q9NWW7; P13196: ALAS1; NbExp=3; IntAct=EBI-2812028, EBI-3905054;
CC Q9NWW7; Q96KQ4: PPP1R13B; NbExp=3; IntAct=EBI-2812028, EBI-1105153;
CC Q9NWW7; O43741: PRKAB2; NbExp=3; IntAct=EBI-2812028, EBI-1053424;
CC Q9NWW7; O43711: TLX3; NbExp=3; IntAct=EBI-2812028, EBI-3939165;
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DR EMBL; AL136834; CAB66768.1; -; mRNA.
DR EMBL; AK000565; BAA91258.1; -; mRNA.
DR EMBL; AK026303; BAB15438.1; -; mRNA.
DR EMBL; AC016700; AAX93192.1; -; Genomic_DNA.
DR EMBL; CH471053; EAW99830.1; -; Genomic_DNA.
DR EMBL; CH471053; EAW99831.1; -; Genomic_DNA.
DR EMBL; BC002825; AAH02825.1; -; mRNA.
DR EMBL; BC005079; AAH05079.1; -; mRNA.
DR CCDS; CCDS1899.1; -.
DR RefSeq; NP_001335687.1; NM_001348758.1.
DR RefSeq; NP_001335688.1; NM_001348759.1.
DR RefSeq; NP_001335689.1; NM_001348760.1.
DR RefSeq; NP_001335690.1; NM_001348761.1.
DR RefSeq; NP_001335691.1; NM_001348762.1.
DR RefSeq; NP_001335692.1; NM_001348763.1.
DR RefSeq; NP_001335693.1; NM_001348764.1.
DR RefSeq; NP_060350.1; NM_017880.2.
DR AlphaFoldDB; Q9NWW7; -.
DR BioGRID; 120316; 8.
DR IntAct; Q9NWW7; 6.
DR STRING; 9606.ENSP00000264434; -.
DR iPTMnet; Q9NWW7; -.
DR PhosphoSitePlus; Q9NWW7; -.
DR BioMuta; C2orf42; -.
DR DMDM; 74734680; -.
DR EPD; Q9NWW7; -.
DR MassIVE; Q9NWW7; -.
DR MaxQB; Q9NWW7; -.
DR PaxDb; Q9NWW7; -.
DR PeptideAtlas; Q9NWW7; -.
DR PRIDE; Q9NWW7; -.
DR ProteomicsDB; 82994; -.
DR Antibodypedia; 31065; 93 antibodies from 16 providers.
DR DNASU; 54980; -.
DR Ensembl; ENST00000264434.7; ENSP00000264434.2; ENSG00000115998.8.
DR Ensembl; ENST00000420306.1; ENSP00000404515.1; ENSG00000115998.8.
DR GeneID; 54980; -.
DR KEGG; hsa:54980; -.
DR MANE-Select; ENST00000264434.7; ENSP00000264434.2; NM_017880.3; NP_060350.1.
DR UCSC; uc002sgh.4; human.
DR CTD; 54980; -.
DR DisGeNET; 54980; -.
DR GeneCards; C2orf42; -.
DR HGNC; HGNC:26056; C2orf42.
DR HPA; ENSG00000115998; Tissue enhanced (testis).
DR neXtProt; NX_Q9NWW7; -.
DR OpenTargets; ENSG00000115998; -.
DR PharmGKB; PA147358740; -.
DR VEuPathDB; HostDB:ENSG00000115998; -.
DR eggNOG; ENOG502R3NH; Eukaryota.
DR GeneTree; ENSGT00390000011031; -.
DR HOGENOM; CLU_022155_0_0_1; -.
DR InParanoid; Q9NWW7; -.
DR OMA; LMDQFQP; -.
DR OrthoDB; 350253at2759; -.
DR PhylomeDB; Q9NWW7; -.
DR TreeFam; TF323774; -.
DR PathwayCommons; Q9NWW7; -.
DR SignaLink; Q9NWW7; -.
DR BioGRID-ORCS; 54980; 9 hits in 1051 CRISPR screens.
DR ChiTaRS; C2orf42; human.
DR GenomeRNAi; 54980; -.
DR Pharos; Q9NWW7; Tdark.
DR PRO; PR:Q9NWW7; -.
DR Proteomes; UP000005640; Chromosome 2.
DR RNAct; Q9NWW7; protein.
DR Bgee; ENSG00000115998; Expressed in sperm and 178 other tissues.
DR ExpressionAtlas; Q9NWW7; baseline and differential.
DR Genevisible; Q9NWW7; HS.
DR GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR InterPro; IPR026049; C2orf42.
DR InterPro; IPR029269; Zf-tcix.
DR PANTHER; PTHR13518; PTHR13518; 1.
DR Pfam; PF14952; zf-tcix; 1.
PE 1: Evidence at protein level;
KW Reference proteome.
FT CHAIN 1..574
FT /note="Uncharacterized protein C2orf42"
FT /id="PRO_0000300121"
FT VARIANT 314
FT /note="Q -> P (in dbSNP:rs3213941)"
FT /id="VAR_050712"
SQ SEQUENCE 574 AA; 64077 MW; 53F6B0495328D7AA CRC64;
MEPNSLRTKV PAFLSDLGKA TLRGIRKCPR CGTYNGTRGL SCKNKTCGTI FRYGARKQPS
VEAVKIITGS DLQVYSVRQR DRGPDYRCFV ELGVSETTIQ TVDGTIITQL SSGRCYVPSC
LKAATQGVVE NQCQHIKLAV NCQAEATPLT LKSSVLNAMQ ASPETKQTIW QLATEPTGPL
VQRITKNILV VKCKASQKHS LGYLHTSFVQ KVSGKSLPER RFFCSCQTLK SHKSNASKDE
TAQRCIHFFA CICAFASDET LAQEFSDFLN FDSSGLKEII VPQLGCHSES TVSACESTAS
KSKKRRKDEV SGAQMNSSLL PQDAVSSNLR KSGLKKPVVA SSLKRQACGQ LLDEAQVTLS
FQDWLASVTE RIHQTMHYQF DGKPEPLVFH IPQSFFDALQ QRISIGSAKK RLPNSTTAFV
RKDALPLGTF SKYTWHITNI LQVKQILDTP EMPLEITRSF IQNRDGTYEL FKCPKVEVES
IAETYGRIEK QPVLRPLELK TFLKVGNTSP DQKEPTPFII EWIPDILPQS KIGELRIKFE
YGHHRNGHVA EYQDQRPPLD QPLELAPLTT ITFP
