CB042_MOUSE
ID CB042_MOUSE Reviewed; 574 AA.
AC Q8R3C1; Q3TB16; Q8BK22; Q8BXH4; Q8R2Z4;
DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 1.
DT 03-AUG-2022, entry version 114.
DE RecName: Full=Uncharacterized protein C2orf42 homolog;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
RC STRAIN=C57BL/6J, and NOD; TISSUE=Cerebellum, and Dendritic cell;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 4).
RC STRAIN=FVB/N, and FVB/N-3; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Name=1;
CC IsoId=Q8R3C1-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8R3C1-2; Sequence=VSP_027793;
CC Name=3;
CC IsoId=Q8R3C1-3; Sequence=VSP_027792;
CC Name=4;
CC IsoId=Q8R3C1-4; Sequence=VSP_027794, VSP_027795;
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DR EMBL; AK047127; BAC32967.1; -; mRNA.
DR EMBL; AK077503; BAC36833.1; -; mRNA.
DR EMBL; AK170524; BAE41857.1; -; mRNA.
DR EMBL; AK171511; BAE42498.1; -; mRNA.
DR EMBL; BC025632; AAH25632.1; -; mRNA.
DR EMBL; BC026926; AAH26926.1; -; mRNA.
DR EMBL; BC031913; AAH31913.1; -; mRNA.
DR CCDS; CCDS20313.1; -. [Q8R3C1-1]
DR CCDS; CCDS57435.1; -. [Q8R3C1-2]
DR RefSeq; NP_001230670.1; NM_001243741.1. [Q8R3C1-2]
DR RefSeq; NP_001230671.1; NM_001243742.1. [Q8R3C1-1]
DR RefSeq; NP_666282.3; NM_146170.4. [Q8R3C1-1]
DR RefSeq; XP_006506036.1; XM_006505973.3. [Q8R3C1-1]
DR RefSeq; XP_006506038.1; XM_006505975.3. [Q8R3C1-1]
DR RefSeq; XP_006506039.1; XM_006505976.3.
DR RefSeq; XP_006506040.1; XM_006505977.3. [Q8R3C1-2]
DR RefSeq; XP_017177018.1; XM_017321529.1.
DR AlphaFoldDB; Q8R3C1; -.
DR iPTMnet; Q8R3C1; -.
DR PhosphoSitePlus; Q8R3C1; -.
DR EPD; Q8R3C1; -.
DR MaxQB; Q8R3C1; -.
DR PaxDb; Q8R3C1; -.
DR PeptideAtlas; Q8R3C1; -.
DR PRIDE; Q8R3C1; -.
DR Antibodypedia; 31065; 93 antibodies from 16 providers.
DR Ensembl; ENSMUST00000050497; ENSMUSP00000057461; ENSMUSG00000046679. [Q8R3C1-1]
DR Ensembl; ENSMUST00000113698; ENSMUSP00000109328; ENSMUSG00000046679. [Q8R3C1-2]
DR Ensembl; ENSMUST00000113700; ENSMUSP00000109330; ENSMUSG00000046679. [Q8R3C1-1]
DR Ensembl; ENSMUST00000133753; ENSMUSP00000121520; ENSMUSG00000046679. [Q8R3C1-4]
DR Ensembl; ENSMUST00000141972; ENSMUSP00000115916; ENSMUSG00000046679. [Q8R3C1-4]
DR GeneID; 232196; -.
DR KEGG; mmu:232196; -.
DR UCSC; uc009cru.2; mouse. [Q8R3C1-1]
DR UCSC; uc009crx.2; mouse. [Q8R3C1-2]
DR CTD; 232196; -.
DR MGI; MGI:2141787; C87436.
DR VEuPathDB; HostDB:ENSMUSG00000046679; -.
DR eggNOG; ENOG502R3NH; Eukaryota.
DR GeneTree; ENSGT00390000011031; -.
DR HOGENOM; CLU_022155_0_0_1; -.
DR InParanoid; Q8R3C1; -.
DR OMA; LMDQFQP; -.
DR OrthoDB; 350253at2759; -.
DR PhylomeDB; Q8R3C1; -.
DR TreeFam; TF323774; -.
DR BioGRID-ORCS; 232196; 1 hit in 73 CRISPR screens.
DR PRO; PR:Q8R3C1; -.
DR Proteomes; UP000000589; Chromosome 6.
DR RNAct; Q8R3C1; protein.
DR Bgee; ENSMUSG00000046679; Expressed in spermatid and 235 other tissues.
DR ExpressionAtlas; Q8R3C1; baseline and differential.
DR Genevisible; Q8R3C1; MM.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR InterPro; IPR026049; C2orf42.
DR InterPro; IPR029269; Zf-tcix.
DR PANTHER; PTHR13518; PTHR13518; 1.
DR Pfam; PF14952; zf-tcix; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Reference proteome.
FT CHAIN 1..574
FT /note="Uncharacterized protein C2orf42 homolog"
FT /id="PRO_0000300123"
FT REGION 297..317
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..188
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_027792"
FT VAR_SEQ 276..285
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_027793"
FT VAR_SEQ 383..387
FT /note="KPEPL -> PTKWS (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_027794"
FT VAR_SEQ 388..574
FT /note="Missing (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_027795"
FT CONFLICT 475
FT /note="K -> Q (in Ref. 1; BAC36833)"
FT /evidence="ECO:0000305"
FT CONFLICT 498
FT /note="E -> G (in Ref. 1; BAC36833)"
FT /evidence="ECO:0000305"
FT CONFLICT 527
FT /note="L -> I (in Ref. 1; BAC32967/BAC36833)"
FT /evidence="ECO:0000305"
FT CONFLICT 572
FT /note="T -> P (in Ref. 1; BAE42498/BAE41857)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 574 AA; 64071 MW; C1A98FA21604950D CRC64;
MEPNSQRTKV PAFLSDLGKA TLRGIRKCPR CGTFNGTRGL SCKNKTCGTI FRYGARKQPS
IEAVKIITGS DLQVYSVRQR DRGPDYRCFV ELGVSETAIQ TVDGTIITQL SSGRCYVPSC
LKAATQGIVE NQCQHIKLAV TCQAEATPLT LKSSVLNALQ AAPETKQSLW QLATEPTGPL
VQRVTKNIMV VKCKASQKHN LGYLHASFMQ KISSRSLPER RFFCSCQTLR PHKSSVPKAE
AAPKCIHFFA CLCAFASDET LAQEFSDFLN FDASGLKEII VPHLGCHAES SVSACESAAS
KPRKRKKDEV SGAQVNSSLM PQDAVNSNLR KSGLKRPVVT SSLKRHVCGQ LLDEAQVTLS
FQDWLASVTE RIHQTMHYQF DGKPEPLVFH IPQSFFDALQ QRISIGSAKK RLPNSTTAFV
RKDALPLGTF SKYTWHITNI LQVKQILDTP EMPLEITRSF IQNRDGTYEL FKCPKVEVEN
IAESYGRIEK QPVLRPLELK TFLKVGNTSP DQKEPTPFII EWIPDILPQS KIGELRIKFE
YGHHRNGHVA DYQDPRPPMD QPLELAPLTT ITFP
