ID   CB066_HUMAN             Reviewed;         117 AA.
AC   Q6UXQ4; B2RNW3;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 105.
DE   RecName: Full=Uncharacterized protein C2orf66;
DE   Flags: Precursor;
GN   Name=C2orf66; ORFNames=UNQ6411/PRO21186;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=12975309; DOI=10.1101/gr.1293003;
RA   Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA   Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA   Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA   Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA   Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA   Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA   Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA   Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT   "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT   identify novel human secreted and transmembrane proteins: a bioinformatics
RT   assessment.";
RL   Genome Res. 13:2265-2270(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
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DR   EMBL; AY358249; AAQ88616.1; -; mRNA.
DR   EMBL; CH471063; EAW70135.1; -; Genomic_DNA.
DR   EMBL; BC137150; AAI37151.1; -; mRNA.
DR   EMBL; BC137151; AAI37152.1; -; mRNA.
DR   RefSeq; NP_998773.1; NM_213608.2.
DR   AlphaFoldDB; Q6UXQ4; -.
DR   BioGRID; 134876; 4.
DR   STRING; 9606.ENSP00000339384; -.
DR   BioMuta; C2orf66; -.
DR   DMDM; 74738241; -.
DR   PaxDb; Q6UXQ4; -.
DR   PRIDE; Q6UXQ4; -.
DR   DNASU; 401027; -.
DR   GeneID; 401027; -.
DR   KEGG; hsa:401027; -.
DR   UCSC; uc002utv.4; human.
DR   CTD; 401027; -.
DR   GeneCards; C2orf66; -.
DR   HGNC; HGNC:33809; C2orf66.
DR   neXtProt; NX_Q6UXQ4; -.
DR   PharmGKB; PA162379428; -.
DR   eggNOG; ENOG502S75F; Eukaryota.
DR   HOGENOM; CLU_172228_0_0_1; -.
DR   InParanoid; Q6UXQ4; -.
DR   OrthoDB; 1483234at2759; -.
DR   PhylomeDB; Q6UXQ4; -.
DR   PathwayCommons; Q6UXQ4; -.
DR   BioGRID-ORCS; 401027; 19 hits in 1048 CRISPR screens.
DR   GenomeRNAi; 401027; -.
DR   Pharos; Q6UXQ4; Tdark.
DR   PRO; PR:Q6UXQ4; -.
DR   Proteomes; UP000005640; Chromosome 2.
DR   RNAct; Q6UXQ4; protein.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   InterPro; IPR031699; DUF4720.
DR   PANTHER; PTHR47620; PTHR47620; 1.
DR   Pfam; PF15846; DUF4720; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..38
FT                   /evidence="ECO:0000255"
FT   CHAIN           39..117
FT                   /note="Uncharacterized protein C2orf66"
FT                   /id="PRO_0000317179"
SQ   SEQUENCE   117 AA;  13321 MW;  A78747D95ECEFDBD CRC64;
     MIIDSSRIPS FTQLHSTMTR APLLLLCVAL VLLGHVNGAT VRNEDKWKPL NNPRNRDLFF
     RRLQAYFKGR GLDLGTFPNP FPTNENPRPL SFQSELTASA SADYEEQKNS FHNYLKG