YCXA_BACSU
ID YCXA_BACSU Reviewed; 408 AA.
AC Q08791;
DT 01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT 26-MAY-2009, sequence version 2.
DT 03-AUG-2022, entry version 127.
DE RecName: Full=Uncharacterized MFS-type transporter YcxA;
DE AltName: Full=ORF5;
GN Name=ycxA; OrderedLocusNames=BSU03530;
OS Bacillus subtilis (strain 168).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX NCBI_TaxID=224308;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=168 / JH642;
RX PubMed=8355609; DOI=10.1111/j.1365-2958.1993.tb01629.x;
RA Cosmina P., Rodriguez F., de Ferra F., Grandi G., Perego M., Venema G.,
RA van Sinderen D.;
RT "Sequence and analysis of the genetic locus responsible for surfactin
RT synthesis in Bacillus subtilis.";
RL Mol. Microbiol. 8:821-831(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=168;
RX PubMed=8969502; DOI=10.1099/13500872-142-11-3047;
RA Yamane K., Kumano M., Kurita K.;
RT "The 25 degrees-36 degrees region of the Bacillus subtilis chromosome:
RT determination of the sequence of a 146 kb segment and identification of 113
RT genes.";
RL Microbiology 142:3047-3056(1996).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=168;
RX PubMed=9384377; DOI=10.1038/36786;
RA Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA Yoshikawa H., Danchin A.;
RT "The complete genome sequence of the Gram-positive bacterium Bacillus
RT subtilis.";
RL Nature 390:249-256(1997).
RN [4]
RP SEQUENCE REVISION TO 7; 12; 149-152 AND 180.
RX PubMed=19383706; DOI=10.1099/mic.0.027839-0;
RA Barbe V., Cruveiller S., Kunst F., Lenoble P., Meurice G., Sekowska A.,
RA Vallenet D., Wang T., Moszer I., Medigue C., Danchin A.;
RT "From a consortium sequence to a unified sequence: the Bacillus subtilis
RT 168 reference genome a decade later.";
RL Microbiology 155:1758-1775(2009).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily.
CC {ECO:0000305}.
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DR EMBL; X70356; CAA49820.1; -; Genomic_DNA.
DR EMBL; D50453; BAA08987.1; -; Genomic_DNA.
DR EMBL; AL009126; CAB12147.2; -; Genomic_DNA.
DR PIR; I40489; I40489.
DR RefSeq; NP_388235.2; NC_000964.3.
DR RefSeq; WP_003246562.1; NZ_JNCM01000031.1.
DR AlphaFoldDB; Q08791; -.
DR SMR; Q08791; -.
DR STRING; 224308.BSU03530; -.
DR TCDB; 2.A.1.11.5; the major facilitator superfamily (mfs).
DR PaxDb; Q08791; -.
DR PRIDE; Q08791; -.
DR EnsemblBacteria; CAB12147; CAB12147; BSU_03530.
DR GeneID; 938307; -.
DR KEGG; bsu:BSU03530; -.
DR PATRIC; fig|224308.179.peg.370; -.
DR eggNOG; COG2814; Bacteria.
DR InParanoid; Q08791; -.
DR OMA; IGYSCAV; -.
DR PhylomeDB; Q08791; -.
DR BioCyc; BSUB:BSU03530-MON; -.
DR Proteomes; UP000001570; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR Gene3D; 1.20.1250.20; -; 2.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR Pfam; PF07690; MFS_1; 1.
DR SUPFAM; SSF103473; SSF103473; 1.
DR PROSITE; PS50850; MFS; 1.
PE 3: Inferred from homology;
KW Cell membrane; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..408
FT /note="Uncharacterized MFS-type transporter YcxA"
FT /id="PRO_0000049484"
FT TRANSMEM 9..29
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 49..69
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 77..97
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 100..120
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 135..155
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 167..187
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 216..236
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 252..272
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 283..303
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 308..328
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 340..360
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 373..393
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CONFLICT 7
FT /note="M -> S (in Ref. 1; CAA49820 and 2; BAA08987)"
FT /evidence="ECO:0000305"
FT CONFLICT 12
FT /note="L -> F (in Ref. 1; CAA49820 and 2; BAA08987)"
FT /evidence="ECO:0000305"
FT CONFLICT 149..152
FT /note="LLLS -> VVSPP (in Ref. 1; CAA49820 and 2; BAA08987)"
FT /evidence="ECO:0000305"
FT CONFLICT 180
FT /note="L -> V (in Ref. 1; CAA49820 and 2; BAA08987)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 408 AA; 44829 MW; 41A6727420BBD494 CRC64;
MRTSPRMKWF VLLFTFVFAI GMNSFRNSFQ FFMLPMADAF HADRSLISVS VSIFMITTGI
VQFFVGFFID RFSVRKIMAL GAVCISASFL VLPYSPNVHV FSAIYGVLGG IGYSCAVGVT
TQYFISCWFD THKGLALAIL TNANSAGLLL LSPIWAAAPY HAGWQSTYTI LGIVMAAVLL
PLLVFGMKHP PHAQAETVKK SYDWRGFWNV MKQSRLIHIL YFGVFTCGFT MGIIDAHLVP
ILKDAHVSHV NGMMAAFGAF IIIGGLLAGW LSDLLGSRSV MLSILFFIRL LSLICLLIPI
LGIHHSDLWY FGFILLFGLS YTGVIPLTAA SISESYQTGL IGSLLGINFF IHQVAGALSV
YAGGLFFDMT HGYLLIVAVC IVFVGLSAVI ELVPFLDKQK AKETHHSI
