CB068_HUMAN
ID CB068_HUMAN Reviewed; 166 AA.
AC Q2NKX9; B4DT10; Q4G0J7; Q6ZVA6;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 07-FEB-2006, sequence version 1.
DT 03-AUG-2022, entry version 113.
DE RecName: Full=UPF0561 protein C2orf68;
GN Name=C2orf68;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Caudate nucleus;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Lung;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q2NKX9; Q9Y2T1: AXIN2; NbExp=3; IntAct=EBI-11603468, EBI-4400025;
CC Q2NKX9; Q9NX55: HYPK; NbExp=5; IntAct=EBI-11603468, EBI-1048743;
CC Q2NKX9; Q63ZY3: KANK2; NbExp=3; IntAct=EBI-11603468, EBI-2556193;
CC Q2NKX9; Q14145: KEAP1; NbExp=4; IntAct=EBI-11603468, EBI-751001;
CC Q2NKX9; Q6A162: KRT40; NbExp=3; IntAct=EBI-11603468, EBI-10171697;
CC Q2NKX9; Q8IUG1: KRTAP1-3; NbExp=3; IntAct=EBI-11603468, EBI-11749135;
CC Q2NKX9; P60410: KRTAP10-8; NbExp=3; IntAct=EBI-11603468, EBI-10171774;
CC Q2NKX9; Q8TBN0: RAB3IL1; NbExp=3; IntAct=EBI-11603468, EBI-743796;
CC Q2NKX9; O15304-2: SIVA1; NbExp=7; IntAct=EBI-11603468, EBI-12372219;
CC Q2NKX9; Q7Z699: SPRED1; NbExp=3; IntAct=EBI-11603468, EBI-5235340;
CC Q2NKX9; P19237: TNNI1; NbExp=3; IntAct=EBI-11603468, EBI-746692;
CC Q2NKX9; O43829: ZBTB14; NbExp=3; IntAct=EBI-11603468, EBI-10176632;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q2NKX9-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q2NKX9-3; Sequence=VSP_032792, VSP_032793;
CC -!- SIMILARITY: Belongs to the UPF0561 family. {ECO:0000305}.
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DR EMBL; AK124808; BAC85956.1; -; mRNA.
DR EMBL; AK300003; BAG61822.1; -; mRNA.
DR EMBL; CH471053; EAW99495.1; -; Genomic_DNA.
DR EMBL; BC111483; AAI11484.1; -; mRNA.
DR CCDS; CCDS42704.1; -. [Q2NKX9-1]
DR RefSeq; NP_001013671.2; NM_001013649.3. [Q2NKX9-1]
DR AlphaFoldDB; Q2NKX9; -.
DR SMR; Q2NKX9; -.
DR BioGRID; 132926; 35.
DR IntAct; Q2NKX9; 21.
DR STRING; 9606.ENSP00000304410; -.
DR iPTMnet; Q2NKX9; -.
DR PhosphoSitePlus; Q2NKX9; -.
DR BioMuta; C2orf68; -.
DR DMDM; 121941598; -.
DR EPD; Q2NKX9; -.
DR MassIVE; Q2NKX9; -.
DR PaxDb; Q2NKX9; -.
DR PeptideAtlas; Q2NKX9; -.
DR PRIDE; Q2NKX9; -.
DR ProteomicsDB; 61415; -. [Q2NKX9-1]
DR ProteomicsDB; 61416; -. [Q2NKX9-3]
DR Antibodypedia; 31940; 42 antibodies from 12 providers.
DR DNASU; 388969; -.
DR Ensembl; ENST00000306336.6; ENSP00000304410.5; ENSG00000168887.11. [Q2NKX9-1]
DR Ensembl; ENST00000409734.3; ENSP00000386301.3; ENSG00000168887.11. [Q2NKX9-3]
DR GeneID; 388969; -.
DR KEGG; hsa:388969; -.
DR MANE-Select; ENST00000306336.6; ENSP00000304410.5; NM_001013649.4; NP_001013671.2.
DR UCSC; uc002sqc.3; human. [Q2NKX9-1]
DR CTD; 388969; -.
DR DisGeNET; 388969; -.
DR GeneCards; C2orf68; -.
DR HGNC; HGNC:34353; C2orf68.
DR HPA; ENSG00000168887; Low tissue specificity.
DR MIM; 618519; gene.
DR neXtProt; NX_Q2NKX9; -.
DR OpenTargets; ENSG00000168887; -.
DR PharmGKB; PA162379474; -.
DR VEuPathDB; HostDB:ENSG00000168887; -.
DR eggNOG; ENOG502S396; Eukaryota.
DR GeneTree; ENSGT00390000001901; -.
DR HOGENOM; CLU_100251_0_0_1; -.
DR InParanoid; Q2NKX9; -.
DR OMA; PVNPDCE; -.
DR PhylomeDB; Q2NKX9; -.
DR TreeFam; TF328804; -.
DR PathwayCommons; Q2NKX9; -.
DR SignaLink; Q2NKX9; -.
DR BioGRID-ORCS; 388969; 28 hits in 1055 CRISPR screens.
DR ChiTaRS; C2orf68; human.
DR GenomeRNAi; 388969; -.
DR Pharos; Q2NKX9; Tdark.
DR PRO; PR:Q2NKX9; -.
DR Proteomes; UP000005640; Chromosome 2.
DR RNAct; Q2NKX9; protein.
DR Bgee; ENSG00000168887; Expressed in hindlimb stylopod muscle and 200 other tissues.
DR ExpressionAtlas; Q2NKX9; baseline and differential.
DR Genevisible; Q2NKX9; HS.
DR InterPro; IPR018888; UPF0561.
DR PANTHER; PTHR34256; PTHR34256; 1.
DR Pfam; PF10573; UPF0561; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Reference proteome.
FT CHAIN 1..166
FT /note="UPF0561 protein C2orf68"
FT /id="PRO_0000328785"
FT REGION 32..107
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 32..46
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 67..87
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 76..127
FT /note="DVSAHPRNPDYEESGESSSSGGSELEPSGHQLFCLEYEADSGEVTSVIVYQG
FT -> GEAARPACLQPARSSCNALPFSIGKNHFLLLRFSSSRLFPEPPPQRSQISAE (in
FT isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_032792"
FT VAR_SEQ 128..166
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_032793"
SQ SEQUENCE 166 AA; 18751 MW; 5BE55D1865157951 CRC64;
MEAGPHPRPG HCCKPGGRLD MNHGFVHHIR RNQIARDDYD KKVKQAAKEK VRRRHTPAPT
RPRKPDLQVY LPRHRDVSAH PRNPDYEESG ESSSSGGSEL EPSGHQLFCL EYEADSGEVT
SVIVYQGDDP GKVSEKVSAH TPLDPPMREA LKLRIQEEIA KRQSQH
