YCZ2_SCHPO
ID YCZ2_SCHPO Reviewed; 442 AA.
AC O74556;
DT 31-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1998, sequence version 1.
DT 25-MAY-2022, entry version 117.
DE RecName: Full=Putative mannan endo-1,6-alpha-mannosidase C970.02;
DE EC=3.2.1.101;
DE AltName: Full=Endo-alpha-1->6-D-mannanase C970.02;
DE Flags: Precursor;
GN ORFNames=SPCC970.02;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Random hydrolysis of (1->6)-alpha-D-mannosidic linkages in
CC unbranched (1->6)-mannans.; EC=3.2.1.101;
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 76 family. {ECO:0000305}.
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DR EMBL; CU329672; CAA20695.1; -; Genomic_DNA.
DR PIR; T41678; T41678.
DR RefSeq; NP_587853.1; NM_001022846.2.
DR AlphaFoldDB; O74556; -.
DR SMR; O74556; -.
DR BioGRID; 275485; 3.
DR STRING; 4896.SPCC970.02.1; -.
DR CAZy; GH76; Glycoside Hydrolase Family 76.
DR PaxDb; O74556; -.
DR EnsemblFungi; SPCC970.02.1; SPCC970.02.1:pep; SPCC970.02.
DR GeneID; 2538908; -.
DR KEGG; spo:SPCC970.02; -.
DR PomBase; SPCC970.02; -.
DR VEuPathDB; FungiDB:SPCC970.02; -.
DR eggNOG; ENOG502QSWP; Eukaryota.
DR HOGENOM; CLU_025694_1_2_1; -.
DR InParanoid; O74556; -.
DR OMA; DGVHFEG; -.
DR PhylomeDB; O74556; -.
DR PRO; PR:O74556; -.
DR Proteomes; UP000002485; Chromosome III.
DR GO; GO:0031362; C:anchored component of external side of plasma membrane; ISO:PomBase.
DR GO; GO:0005783; C:endoplasmic reticulum; HDA:PomBase.
DR GO; GO:0008496; F:mannan endo-1,6-alpha-mannosidase activity; ISM:PomBase.
DR GO; GO:0051692; P:cellular oligosaccharide catabolic process; IC:PomBase.
DR GO; GO:0009272; P:fungal-type cell wall biogenesis; ISO:PomBase.
DR InterPro; IPR008928; 6-hairpin_glycosidase_sf.
DR InterPro; IPR005198; Glyco_hydro_76.
DR InterPro; IPR014480; Mannan-1_6-alpha_mannosidase.
DR PANTHER; PTHR12145; PTHR12145; 1.
DR Pfam; PF03663; Glyco_hydro_76; 1.
DR PIRSF; PIRSF016302; Man_a_manosd; 1.
DR SUPFAM; SSF48208; SSF48208; 1.
PE 3: Inferred from homology;
KW Glycoprotein; Glycosidase; Hydrolase; Reference proteome; Signal.
FT SIGNAL 1..19
FT /evidence="ECO:0000255"
FT CHAIN 20..442
FT /note="Putative mannan endo-1,6-alpha-mannosidase C970.02"
FT /id="PRO_0000012131"
FT CARBOHYD 25
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 82
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 107
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 131
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 201
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 236
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 261
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 264
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 277
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 361
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 442 AA; 49135 MW; 97DFEF581B0ED97D CRC64;
MSLTIFISLA TILFSFAEAI SVDLNDTSSV DLATSLVADG LLNYYAGQHK GGTIGMFLPP
AYWWEAGAAW NGLLNRYIAT GNSTYNELVK TSMLYQSGED SDYMPSNYTT SEGNDDQAFW
GLTVISAAEA NFSNPAADEP QWLELAQAVF NQQVTRWDTD HCNGGLRWQI TEFNSGYNYK
NTVSNGAFFQ LAARLARFTD NDTYAEWANV AYDWSQRIGF IQEDYTVFDG SSIKDNCSSI
EITQWTYNIG LYMAGAAYMY NYTNSTVWKT RVEGFANKTA KTFFFKDIMF EPVCEIALSC
NYDQTSFKGF LTRFMVYTAQ MAPFTAPLLE PLLISTAKAA AGACCGGYDG VTCGVQWWWN
NDTWDGLYGL GEQMSALEAI QAPLLLKSLQ VFKASNGGSS TGDPNAGLYT APVSFANKNF
ENLRKHWMLL GFFLLVPTLV LY
