YCZ8_SCHPO
ID YCZ8_SCHPO Reviewed; 967 AA.
AC O74561;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1998, sequence version 1.
DT 03-AUG-2022, entry version 109.
DE RecName: Full=Uncharacterized inositol polyphosphate kinase C970.08;
DE EC=2.7.-.-;
GN ORFNames=SPCC970.08;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1] {ECO:0000312|EMBL:CAA20701.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2] {ECO:0000305}
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-86 AND SER-585, AND
RP IDENTIFICATION BY MASS SPECTROMETRY.
RX PubMed=18257517; DOI=10.1021/pr7006335;
RA Wilson-Grady J.T., Villen J., Gygi S.P.;
RT "Phosphoproteome analysis of fission yeast.";
RL J. Proteome Res. 7:1088-1097(2008).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16823372}.
CC -!- SIMILARITY: Belongs to the inositol phosphokinase (IPK) family.
CC {ECO:0000255}.
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DR EMBL; CU329672; CAA20701.1; -; Genomic_DNA.
DR PIR; T41672; T41672.
DR RefSeq; NP_587847.1; NM_001022840.2.
DR AlphaFoldDB; O74561; -.
DR SMR; O74561; -.
DR BioGRID; 275482; 1.
DR STRING; 4896.SPCC970.08.1; -.
DR iPTMnet; O74561; -.
DR MaxQB; O74561; -.
DR PaxDb; O74561; -.
DR PRIDE; O74561; -.
DR EnsemblFungi; SPCC970.08.1; SPCC970.08.1:pep; SPCC970.08.
DR GeneID; 2538905; -.
DR KEGG; spo:SPCC970.08; -.
DR PomBase; SPCC970.08; -.
DR VEuPathDB; FungiDB:SPCC970.08; -.
DR eggNOG; KOG1620; Eukaryota.
DR HOGENOM; CLU_306329_0_0_1; -.
DR InParanoid; O74561; -.
DR OMA; PFKHQVG; -.
DR PhylomeDB; O74561; -.
DR Reactome; R-SPO-1855167; Synthesis of pyrophosphates in the cytosol.
DR Reactome; R-SPO-1855191; Synthesis of IPs in the nucleus.
DR PRO; PR:O74561; -.
DR Proteomes; UP000002485; Chromosome III.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005829; C:cytosol; HDA:PomBase.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000829; F:inositol heptakisphosphate kinase activity; ISO:PomBase.
DR GO; GO:0000828; F:inositol hexakisphosphate kinase activity; IBA:GO_Central.
DR GO; GO:0000827; F:inositol-1,3,4,5,6-pentakisphosphate kinase activity; ISO:PomBase.
DR GO; GO:0016301; F:kinase activity; IBA:GO_Central.
DR GO; GO:0032958; P:inositol phosphate biosynthetic process; ISO:PomBase.
DR GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IBA:GO_Central.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0023052; P:signaling; NAS:PomBase.
DR Gene3D; 3.30.470.160; -; 1.
DR InterPro; IPR005522; IPK.
DR InterPro; IPR038286; IPK_sf.
DR PANTHER; PTHR12400; PTHR12400; 1.
DR Pfam; PF03770; IPK; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Kinase; Phosphoprotein; Reference proteome; Transferase.
FT CHAIN 1..967
FT /note="Uncharacterized inositol polyphosphate kinase
FT C970.08"
FT /id="PRO_0000318136"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 41..72
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 135..259
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 271..296
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 380..399
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 437..464
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 499..544
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 594..665
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 681..708
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 157..201
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 207..221
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 239..258
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 271..295
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 529..544
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 604..618
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 687..708
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 728..736
FT /ligand="substrate"
FT /evidence="ECO:0000250|UniProtKB:Q12494"
FT MOD_RES 86
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18257517"
FT MOD_RES 585
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18257517"
SQ SEQUENCE 967 AA; 108719 MW; B09B252004368A30 CRC64;
MQNAPKCYLP NSRKGRDVNF HDRGPETLKC LYDESEDNNN FTMHSESIGP KSLDSLSPRR
LSNYSSAVDP RTTSLEDVPR LILTRSNSQE QTPLRTHTPV EYMSDSIHKS LADLQLGGSS
YSVAESPVPV LQSSAVSEAD DMASAHSAHP SRKASRSLRL FESSTSNNLE TGNSTNTALH
NVSSPLESVS ERLSKSGSPS VGAQHDLDEV ISEKDTSLSR RSSRGRSSAP KRRKDSGSSK
TTATYIPHNP SKKSSQHLPL LPDASFELER SVSRSYQSPA STPRSSVSSV SSSPPEDHPF
FHWNVDYPVT VRLEPFKHQV GGHTAFFRFS KRAVCKPLTR NENTFYETIE ACHPELLPFI
PKYIGVLNVT HTITKTEEND STTEYVNTES SSKTPAPHKH TFNSCYQKKD YGYIPEVSVE
QNRHIFPEWM LPDKRSHSYG SPKSLHHKSS SAGERPVSPT FVADIPPKTP WGTTLINRKL
REEVLREVFA PKHARRRLGT RFHSRSSHRP SVFRDNSVAF GQLDNGNTSS RARDKDADPN
KSLSCSVEDK HYDLHSAVAE ENEEVDEELL NVPSNNQGKS YRRFSSDAVW EEPESNEFPR
VSGTMEDYDS RESTGHTIKE LRSTPNSHGT VPDDSIFAMD NEENSELPPP LEPAEIGDPF
RSVNDPRRVL SLPHMASADE DHRIPASDNQ NNNNNDANAL AENSESQHST QIERYIVIED
LTSGMKRPCV LDVKMGTRQY GIMATEKKKA SQTKKCAMTT SRVLGVRICG MQVWHPWLQS
YTFEDKYVGR DIKAGEEFQH ALMRYLGKTD DDEDNSHLLV HHIPTIIRKL EQLEQIVRFL
KGSRLYASSL LFLYDGEPPP SDKSSKEKVK PREIDIRIVD FANCVFAEDK ELLAKATCPP
QHKDTYDRGY VRGLRTLRLY FLKIWKEAKG MQIAERGYED SLSNAYDELG GLMSYSNDDD
SCGETST
