CB069_MOUSE
ID CB069_MOUSE Reviewed; 365 AA.
AC Q9D9H8; E9QNR4;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 27-JUL-2011, sequence version 3.
DT 03-AUG-2022, entry version 99.
DE RecName: Full=Mitochondrial protein C2orf69 homolog;
DE Flags: Precursor;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 5-365.
RC STRAIN=C57BL/6J; TISSUE=Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
CC -!- FUNCTION: May play a role in the respiratory chain.
CC {ECO:0000250|UniProtKB:Q8N8R5}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion matrix
CC {ECO:0000250|UniProtKB:Q8N8R5}.
CC -!- SIMILARITY: Belongs to the C2orf69 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB24787.1; Type=Frameshift; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AC161493; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AK006906; BAB24787.1; ALT_FRAME; mRNA.
DR CCDS; CCDS48264.1; -.
DR RefSeq; NP_082822.1; NM_028546.1.
DR AlphaFoldDB; Q9D9H8; -.
DR STRING; 10090.ENSMUSP00000040240; -.
DR GlyGen; Q9D9H8; 2 sites.
DR PhosphoSitePlus; Q9D9H8; -.
DR EPD; Q9D9H8; -.
DR MaxQB; Q9D9H8; -.
DR PaxDb; Q9D9H8; -.
DR PeptideAtlas; Q9D9H8; -.
DR PRIDE; Q9D9H8; -.
DR Antibodypedia; 50407; 42 antibodies from 11 providers.
DR Ensembl; ENSMUST00000042734; ENSMUSP00000040240; ENSMUSG00000038323.
DR GeneID; 73467; -.
DR KEGG; mmu:73467; -.
DR UCSC; uc007bay.2; mouse.
DR MGI; MGI:1920717; 1700066M21Rik.
DR VEuPathDB; HostDB:ENSMUSG00000038323; -.
DR eggNOG; KOG2800; Eukaryota.
DR GeneTree; ENSGT00390000005550; -.
DR HOGENOM; CLU_028841_1_0_1; -.
DR InParanoid; Q9D9H8; -.
DR OMA; YQVFDTM; -.
DR OrthoDB; 1550048at2759; -.
DR PhylomeDB; Q9D9H8; -.
DR TreeFam; TF343859; -.
DR BioGRID-ORCS; 73467; 4 hits in 72 CRISPR screens.
DR PRO; PR:Q9D9H8; -.
DR Proteomes; UP000000589; Chromosome 1.
DR RNAct; Q9D9H8; protein.
DR Bgee; ENSMUSG00000038323; Expressed in spermatocyte and 231 other tissues.
DR Genevisible; Q9D9H8; MM.
DR GO; GO:0005759; C:mitochondrial matrix; IEA:UniProtKB-SubCell.
DR GO; GO:0005739; C:mitochondrion; ISO:MGI.
DR GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR GO; GO:0006119; P:oxidative phosphorylation; ISO:MGI.
DR InterPro; IPR018881; C2orf69_mit.
DR PANTHER; PTHR31296; PTHR31296; 1.
DR Pfam; PF10561; UPF0565; 1.
PE 2: Evidence at transcript level;
KW Electron transport; Mitochondrion; Reference proteome; Respiratory chain;
KW Transit peptide; Transport.
FT TRANSIT 1..24
FT /note="Mitochondrion"
FT /evidence="ECO:0000255"
FT CHAIN 25..365
FT /note="Mitochondrial protein C2orf69 homolog"
FT /id="PRO_0000329089"
FT REGION 28..64
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 50..64
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 110
FT /note="W -> G (in Ref. 2; BAB24787)"
FT /evidence="ECO:0000305"
FT CONFLICT 157
FT /note="E -> A (in Ref. 2; BAB24787)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 365 AA; 41689 MW; B2ECDA7B30A9643F CRC64;
MLGSRRLRSP ALVLLLLRPL LASGDSASRL QTRAMNPGGG ERGSPEDSHR LQRSTVPGSD
PQRSNELLLL TSREGDSPEQ RHHVLYFPGD VQNYHEIMTR HPENYQWENW SLENIATILA
RRFPNSYIWV IKCSRMHLHK FSCYDNFVKS NMFGAPEHTP DFGAFKHLYM LLVNAFNLTQ
NGMLFKNRSV WNKDCKASNC ESNPSTSNGG QKENERTCEH VDEPSMSFPP LSLDGASFTL
IGFSKGCVVL NQLLFELKEA KKDKNIDAFI KSIRTMYWLD GGHSGGSNTW VTYPEVLEEF
AQTGITVHTH VTPYQVHDPM RSWIGKEHKK FVQILRDLGM QVTSQIHFAK ETPSIENHFR
VHEVF
