ID   YD073_YEAST             Reviewed;         984 AA.
AC   Q07454; D6VRS6;
DT   05-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 120.
DE   RecName: Full=UPF0592 protein YDL073W;
GN   OrderedLocusNames=YDL073W;
OS   Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=559292;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=9169867;
RA   Jacq C., Alt-Moerbe J., Andre B., Arnold W., Bahr A., Ballesta J.P.G.,
RA   Bargues M., Baron L., Becker A., Biteau N., Bloecker H., Blugeon C.,
RA   Boskovic J., Brandt P., Brueckner M., Buitrago M.J., Coster F.,
RA   Delaveau T., del Rey F., Dujon B., Eide L.G., Garcia-Cantalejo J.M.,
RA   Goffeau A., Gomez-Peris A., Granotier C., Hanemann V., Hankeln T.,
RA   Hoheisel J.D., Jaeger W., Jimenez A., Jonniaux J.-L., Kraemer C.,
RA   Kuester H., Laamanen P., Legros Y., Louis E.J., Moeller-Rieker S.,
RA   Monnet A., Moro M., Mueller-Auer S., Nussbaumer B., Paricio N., Paulin L.,
RA   Perea J., Perez-Alonso M., Perez-Ortin J.E., Pohl T.M., Prydz H.,
RA   Purnelle B., Rasmussen S.W., Remacha M.A., Revuelta J.L., Rieger M.,
RA   Salom D., Saluz H.P., Saiz J.E., Saren A.-M., Schaefer M., Scharfe M.,
RA   Schmidt E.R., Schneider C., Scholler P., Schwarz S., Soler-Mira A.,
RA   Urrestarazu L.A., Verhasselt P., Vissers S., Voet M., Volckaert G.,
RA   Wagner G., Wambutt R., Wedler E., Wedler H., Woelfl S., Harris D.E.,
RA   Bowman S., Brown D., Churcher C.M., Connor R., Dedman K., Gentles S.,
RA   Hamlin N., Hunt S., Jones L., McDonald S., Murphy L.D., Niblett D.,
RA   Odell C., Oliver K., Rajandream M.A., Richards C., Shore L., Walsh S.V.,
RA   Barrell B.G., Dietrich F.S., Mulligan J.T., Allen E., Araujo R., Aviles E.,
RA   Berno A., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M.,
RA   Hunicke-Smith S., Hyman R.W., Komp C., Lashkari D., Lew H., Lin D.,
RA   Mosedale D., Nakahara K., Namath A., Oefner P., Oh C., Petel F.X.,
RA   Roberts D., Schramm S., Schroeder M., Shogren T., Shroff N., Winant A.,
RA   Yelton M.A., Botstein D., Davis R.W., Johnston M., Andrews S., Brinkman R.,
RA   Cooper J., Ding H., Du Z., Favello A., Fulton L., Gattung S., Greco T.,
RA   Hallsworth K., Hawkins J., Hillier L.W., Jier M., Johnson D., Johnston L.,
RA   Kirsten J., Kucaba T., Langston Y., Latreille P., Le T., Mardis E.,
RA   Menezes S., Miller N., Nhan M., Pauley A., Peluso D., Rifkin L., Riles L.,
RA   Taich A., Trevaskis E., Vignati D., Wilcox L., Wohldman P., Vaudin M.,
RA   Wilson R., Waterston R., Albermann K., Hani J., Heumann K., Kleine K.,
RA   Mewes H.-W., Zollner A., Zaccaria P.;
RT   "The nucleotide sequence of Saccharomyces cerevisiae chromosome IV.";
RL   Nature 387:75-78(1997).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=24374639; DOI=10.1534/g3.113.008995;
RA   Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA   Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA   Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT   "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL   G3 (Bethesda) 4:389-398(2014).
RN   [3]
RP   DISRUPTION PHENOTYPE.
RX   PubMed=11054825;
RX   DOI=10.1002/1097-0061(200011)16:15<1437::aid-yea633>3.0.co;2-d;
RA   Blasco A., Sanz P.;
RT   "Disruption and functional analysis of six ORFs on chromosome IV: YDL053c,
RT   YDL072c, YDL073w, YDL076c, YDL077c and YDL080c.";
RL   Yeast 16:1437-1443(2000).
RN   [4]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=19779198; DOI=10.1126/science.1172867;
RA   Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.;
RT   "Global analysis of Cdk1 substrate phosphorylation sites provides insights
RT   into evolution.";
RL   Science 325:1682-1686(2009).
CC   -!- DISRUPTION PHENOTYPE: Cells are viable and do not display any
CC       phenotype. {ECO:0000269|PubMed:11054825}.
CC   -!- SIMILARITY: Belongs to the UPF0592 family. {ECO:0000305}.
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DR   EMBL; Z74121; CAA98639.1; -; Genomic_DNA.
DR   EMBL; BK006938; DAA11786.1; -; Genomic_DNA.
DR   PIR; S67609; S67609.
DR   RefSeq; NP_010210.1; NM_001180132.1.
DR   AlphaFoldDB; Q07454; -.
DR   BioGRID; 31988; 72.
DR   IntAct; Q07454; 7.
DR   MINT; Q07454; -.
DR   STRING; 4932.YDL073W; -.
DR   iPTMnet; Q07454; -.
DR   MaxQB; Q07454; -.
DR   PaxDb; Q07454; -.
DR   PRIDE; Q07454; -.
DR   EnsemblFungi; YDL073W_mRNA; YDL073W; YDL073W.
DR   GeneID; 851486; -.
DR   KEGG; sce:YDL073W; -.
DR   SGD; S000002231; YDL073W.
DR   VEuPathDB; FungiDB:YDL073W; -.
DR   eggNOG; ENOG502QQ52; Eukaryota.
DR   HOGENOM; CLU_006978_0_0_1; -.
DR   InParanoid; Q07454; -.
DR   OMA; WHYWYII; -.
DR   BioCyc; YEAST:G3O-29484-MON; -.
DR   PRO; PR:Q07454; -.
DR   Proteomes; UP000002311; Chromosome IV.
DR   RNAct; Q07454; protein.
DR   GO; GO:0005078; F:MAP-kinase scaffold activity; IPI:SGD.
DR   GO; GO:0043407; P:negative regulation of MAP kinase activity; IGI:SGD.
DR   GO; GO:0007232; P:osmosensory signaling pathway via Sho1 osmosensor; IGI:SGD.
DR   InterPro; IPR013887; UPF0592.
DR   Pfam; PF08578; DUF1765; 1.
PE   1: Evidence at protein level;
KW   Reference proteome.
FT   CHAIN           1..984
FT                   /note="UPF0592 protein YDL073W"
FT                   /id="PRO_0000248460"
FT   REGION          675..712
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   984 AA;  113891 MW;  9854EBE15C88DF0B CRC64;
     MGPAIHNQLY ECGLKTTSQD GFLMDNYETQ LFQSLNRFIN FINNANQSAS NKEQNTKFCK
     SSSNFLRLKL LTVLRQWCDS SRSNCTLEVR DVLTQWWVTL LNFLNSDTSL QIDTALELSL
     SIELTSVCLE CLSKIMTILI ILPFHSSRDM EIYSHHLLLT IHCITNKLIL ISKNSKKLKR
     TNSDDKCSIN DKKLQYLNKY SSLLRAFIGK LNAYAFFYLP EDFHFDTILL LTVSPQISSS
     IQTSLFSWKK RQYKFTDDQG QMIRTEAFEN KDTKFFKIIV SYIKNDFVLM SFYWHYWYII
     LQFMKFSDSD VGIKKSTLSC IPGSEILLTH VTTRFLNSDL NKFTRIIKQT PNPRIANENV
     TESHPNFKSL NSSNALITSE RINDYVFSNF KTIKLWECLR SLSGCILKEN HPEYLENMLS
     LHESLLIDYV STISAYDYIA ANVIYNKVLQ FIIFQFESLP SLKFIQWRSW YNGLLSMLRT
     KNVNCQTVSL LCLFNIWKHV TIEDRDEIVK VLLSDFWESL IFENEFPLIR ILFMKVLVFK
     IIPSVQNSSS LRFLPHDRIK QLYEELLVNK EELFEMQKHD SNDIVAHRKN ALVFNGNSRL
     MMIPKKPNTE DHLVYKINHD KNLTTERFPS VSSVANTRPN VILKNGKYAY DILDEMTSKA
     AFLLAEKKTR LNPKKNHKIM DGYEGGQENE DNDEDSEDSG SHKNKRKEGN SSLSATLNTW
     LSKFSSTSED SQKKKEQANE LGNDFEYDED VADFAEILPK QSSSNIEKIF KHGNNSGSMV
     SYNSSIKLNR RENILIGPPE LRFSNEIKEH NSIATIFKLV FIQTNRRVVE KIDLANMKWG
     TIHGGSKYMK PLPVPKDLVA SVAKNESETR NLATLCGNGL DFEIPVPDFN IFGKCMEDEQ
     DVAKIGNQNV EDLKVTGGRE VTIWKQIQDM KLRTRIQKIC VLIETFNATV REYFEFSNRL
     EHDGIFIDFE VRKPSSNNSI NIKV