ID   CB072_HUMAN             Reviewed;         295 AA.
AC   A6NCS6;
DT   10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-APR-2011, sequence version 2.
DT   03-AUG-2022, entry version 92.
DE   RecName: Full=Uncharacterized protein C2orf72;
GN   Name=C2orf72;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15815621; DOI=10.1038/nature03466;
RA   Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA   Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA   Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA   Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA   Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA   Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA   Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA   Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA   Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA   McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA   Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA   Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA   Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA   Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA   Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA   Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA   Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA   Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA   Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA   Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA   Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA   Wilson R.K.;
RT   "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT   4.";
RL   Nature 434:724-731(2005).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Liver;
RX   PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA   Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L.,
RA   Ye M., Zou H.;
RT   "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver
RT   phosphoproteome.";
RL   J. Proteomics 96:253-262(2014).
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DR   EMBL; AC009407; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS46539.1; -.
DR   RefSeq; NP_001138466.1; NM_001144994.1.
DR   AlphaFoldDB; A6NCS6; -.
DR   BioGRID; 129217; 6.
DR   IntAct; A6NCS6; 1.
DR   STRING; 9606.ENSP00000362743; -.
DR   iPTMnet; A6NCS6; -.
DR   PhosphoSitePlus; A6NCS6; -.
DR   BioMuta; C2orf72; -.
DR   jPOST; A6NCS6; -.
DR   MassIVE; A6NCS6; -.
DR   MaxQB; A6NCS6; -.
DR   PaxDb; A6NCS6; -.
DR   PeptideAtlas; A6NCS6; -.
DR   PRIDE; A6NCS6; -.
DR   ProteomicsDB; 859; -.
DR   Antibodypedia; 50518; 13 antibodies from 7 providers.
DR   DNASU; 257407; -.
DR   Ensembl; ENST00000373640.5; ENSP00000362743.4; ENSG00000204128.6.
DR   GeneID; 257407; -.
DR   KEGG; hsa:257407; -.
DR   MANE-Select; ENST00000373640.5; ENSP00000362743.4; NM_001144994.2; NP_001138466.1.
DR   UCSC; uc002vrl.5; human.
DR   CTD; 257407; -.
DR   GeneCards; C2orf72; -.
DR   HGNC; HGNC:27418; C2orf72.
DR   HPA; ENSG00000204128; Group enriched (brain, liver).
DR   neXtProt; NX_A6NCS6; -.
DR   OpenTargets; ENSG00000204128; -.
DR   VEuPathDB; HostDB:ENSG00000204128; -.
DR   eggNOG; ENOG502S7XX; Eukaryota.
DR   GeneTree; ENSGT00390000003006; -.
DR   HOGENOM; CLU_939971_0_0_1; -.
DR   InParanoid; A6NCS6; -.
DR   OMA; PWSRGKN; -.
DR   OrthoDB; 1274440at2759; -.
DR   PhylomeDB; A6NCS6; -.
DR   TreeFam; TF339232; -.
DR   PathwayCommons; A6NCS6; -.
DR   SignaLink; A6NCS6; -.
DR   BioGRID-ORCS; 257407; 15 hits in 1045 CRISPR screens.
DR   ChiTaRS; C2orf72; human.
DR   GenomeRNAi; 257407; -.
DR   Pharos; A6NCS6; Tdark.
DR   PRO; PR:A6NCS6; -.
DR   Proteomes; UP000005640; Chromosome 2.
DR   RNAct; A6NCS6; protein.
DR   Bgee; ENSG00000204128; Expressed in right lobe of liver and 147 other tissues.
DR   Genevisible; A6NCS6; HS.
DR   InterPro; IPR027868; DUF4630.
DR   Pfam; PF15443; DUF4630; 1.
PE   1: Evidence at protein level;
KW   Reference proteome.
FT   CHAIN           1..295
FT                   /note="Uncharacterized protein C2orf72"
FT                   /id="PRO_0000339300"
SQ   SEQUENCE   295 AA;  30481 MW;  A047D9A53A30FA93 CRC64;
     MERELEALAA RLARPAEPPF QALVEAAGGR GQVLLVGELW EREQSRALLR DFARAVFPPE
     PGAAKPGGAA AEGAGPGAAR GAQRAARAAG AAGAAAAAAR AIRSPLVFVL CRASSLAARE
     PRRRLREMLR DVRGRRRAGA ALVGVLVAEA GPEDAVAPGL RLLEALLRAV FGRQAGGPVQ
     AAAYCPGLPA SCLAVQAAAC RALQAAGAGQ PVEGAWERPG LPGLLACFSW GPWSRRKNQD
     VAACRSSAQE DFQEPEEELP LTAIFPNGDC DDLGRGSKAC DGVVHTPAEP TGDSR