ID   YD109_YEAST             Reviewed;         647 AA.
AC   Q12103; D6VRP1;
DT   27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 141.
DE   RecName: Full=Putative lipase YDL109C;
DE            EC=3.1.-.-;
GN   OrderedLocusNames=YDL109C; ORFNames=D2325;
OS   Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=559292;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 96604 / S288c / FY1679;
RX   PubMed=8923743;
RX   DOI=10.1002/(sici)1097-0061(199610)12:13%3c1377::aid-yea35%3e3.0.co;2-r;
RA   Boskovic J., Soler-Mira A., Garcia-Cantalejo J.M., Ballesta J.P.G.,
RA   Jimenez A., Remacha M.A.;
RT   "The sequence of a 16,691 bp segment of Saccharomyces cerevisiae chromosome
RT   IV identifies the DUN1, PMT1, PMT5, SRP14 and DPR1 genes, and five new open
RT   reading frames.";
RL   Yeast 12:1377-1384(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=9169867;
RA   Jacq C., Alt-Moerbe J., Andre B., Arnold W., Bahr A., Ballesta J.P.G.,
RA   Bargues M., Baron L., Becker A., Biteau N., Bloecker H., Blugeon C.,
RA   Boskovic J., Brandt P., Brueckner M., Buitrago M.J., Coster F.,
RA   Delaveau T., del Rey F., Dujon B., Eide L.G., Garcia-Cantalejo J.M.,
RA   Goffeau A., Gomez-Peris A., Granotier C., Hanemann V., Hankeln T.,
RA   Hoheisel J.D., Jaeger W., Jimenez A., Jonniaux J.-L., Kraemer C.,
RA   Kuester H., Laamanen P., Legros Y., Louis E.J., Moeller-Rieker S.,
RA   Monnet A., Moro M., Mueller-Auer S., Nussbaumer B., Paricio N., Paulin L.,
RA   Perea J., Perez-Alonso M., Perez-Ortin J.E., Pohl T.M., Prydz H.,
RA   Purnelle B., Rasmussen S.W., Remacha M.A., Revuelta J.L., Rieger M.,
RA   Salom D., Saluz H.P., Saiz J.E., Saren A.-M., Schaefer M., Scharfe M.,
RA   Schmidt E.R., Schneider C., Scholler P., Schwarz S., Soler-Mira A.,
RA   Urrestarazu L.A., Verhasselt P., Vissers S., Voet M., Volckaert G.,
RA   Wagner G., Wambutt R., Wedler E., Wedler H., Woelfl S., Harris D.E.,
RA   Bowman S., Brown D., Churcher C.M., Connor R., Dedman K., Gentles S.,
RA   Hamlin N., Hunt S., Jones L., McDonald S., Murphy L.D., Niblett D.,
RA   Odell C., Oliver K., Rajandream M.A., Richards C., Shore L., Walsh S.V.,
RA   Barrell B.G., Dietrich F.S., Mulligan J.T., Allen E., Araujo R., Aviles E.,
RA   Berno A., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M.,
RA   Hunicke-Smith S., Hyman R.W., Komp C., Lashkari D., Lew H., Lin D.,
RA   Mosedale D., Nakahara K., Namath A., Oefner P., Oh C., Petel F.X.,
RA   Roberts D., Schramm S., Schroeder M., Shogren T., Shroff N., Winant A.,
RA   Yelton M.A., Botstein D., Davis R.W., Johnston M., Andrews S., Brinkman R.,
RA   Cooper J., Ding H., Du Z., Favello A., Fulton L., Gattung S., Greco T.,
RA   Hallsworth K., Hawkins J., Hillier L.W., Jier M., Johnson D., Johnston L.,
RA   Kirsten J., Kucaba T., Langston Y., Latreille P., Le T., Mardis E.,
RA   Menezes S., Miller N., Nhan M., Pauley A., Peluso D., Rifkin L., Riles L.,
RA   Taich A., Trevaskis E., Vignati D., Wilcox L., Wohldman P., Vaudin M.,
RA   Wilson R., Waterston R., Albermann K., Hani J., Heumann K., Kleine K.,
RA   Mewes H.-W., Zollner A., Zaccaria P.;
RT   "The nucleotide sequence of Saccharomyces cerevisiae chromosome IV.";
RL   Nature 387:75-78(1997).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=24374639; DOI=10.1534/g3.113.008995;
RA   Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA   Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA   Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT   "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL   G3 (Bethesda) 4:389-398(2014).
RN   [4]
RP   FUNCTION.
RX   PubMed=10341423;
RX   DOI=10.1002/(sici)1097-0061(199905)15:7<601::aid-yea390>3.0.co;2-n;
RA   Daum G., Tuller G., Nemec T., Hrastnik C., Balliano G., Cattel L.,
RA   Milla P., Rocco F., Conzelmann A., Vionnet C., Kelly D.E., Kelly S.,
RA   Schweizer E., Schueller H.-J., Hojad U., Greiner E., Finger K.;
RT   "Systematic analysis of yeast strains with possible defects in lipid
RT   metabolism.";
RL   Yeast 15:601-614(1999).
RN   [5]
RP   LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX   PubMed=14562106; DOI=10.1038/nature02046;
RA   Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA   O'Shea E.K., Weissman J.S.;
RT   "Global analysis of protein expression in yeast.";
RL   Nature 425:737-741(2003).
CC   -!- FUNCTION: Involved in lipid metabolism. {ECO:0000269|PubMed:10341423}.
CC   -!- MISCELLANEOUS: Present with 195 molecules/cell in log phase SD medium.
CC       {ECO:0000269|PubMed:14562106}.
CC   -!- SIMILARITY: Belongs to the putative lipase ROG1 family. {ECO:0000305}.
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DR   EMBL; X95644; CAA64903.1; -; Genomic_DNA.
DR   EMBL; Z74157; CAA98676.1; -; Genomic_DNA.
DR   EMBL; BK006938; DAA11751.1; -; Genomic_DNA.
DR   PIR; S67651; S67651.
DR   RefSeq; NP_010174.1; NM_001180168.1.
DR   AlphaFoldDB; Q12103; -.
DR   BioGRID; 31953; 29.
DR   STRING; 4932.YDL109C; -.
DR   ESTHER; yeast-YDL109C; Duf_676.
DR   iPTMnet; Q12103; -.
DR   PaxDb; Q12103; -.
DR   PRIDE; Q12103; -.
DR   EnsemblFungi; YDL109C_mRNA; YDL109C; YDL109C.
DR   GeneID; 851449; -.
DR   KEGG; sce:YDL109C; -.
DR   SGD; S000002267; YDL109C.
DR   VEuPathDB; FungiDB:YDL109C; -.
DR   eggNOG; KOG4372; Eukaryota.
DR   GeneTree; ENSGT00940000176402; -.
DR   HOGENOM; CLU_007367_1_0_1; -.
DR   InParanoid; Q12103; -.
DR   OMA; CFITADQ; -.
DR   BioCyc; YEAST:G3O-29510-MON; -.
DR   PRO; PR:Q12103; -.
DR   Proteomes; UP000002311; Chromosome IV.
DR   RNAct; Q12103; protein.
DR   GO; GO:0047372; F:acylglycerol lipase activity; IBA:GO_Central.
DR   GO; GO:0044255; P:cellular lipid metabolic process; IBA:GO_Central.
DR   GO; GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.1820; -; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR007751; DUF676_lipase-like.
DR   InterPro; IPR044294; Lipase-like.
DR   InterPro; IPR016445; Rog1_fam.
DR   PANTHER; PTHR12482; PTHR12482; 2.
DR   Pfam; PF05057; DUF676; 1.
DR   PIRSF; PIRSF005412; UCP005412_abhydr; 1.
DR   SUPFAM; SSF53474; SSF53474; 1.
DR   PROSITE; PS00120; LIPASE_SER; 1.
PE   1: Evidence at protein level;
KW   Hydrolase; Lipid degradation; Lipid metabolism; Reference proteome.
FT   CHAIN           1..647
FT                   /note="Putative lipase YDL109C"
FT                   /id="PRO_0000240859"
FT   REGION          502..523
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        274
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10037"
SQ   SEQUENCE   647 AA;  72856 MW;  BA56D5C9D42AF0FE CRC64;
     MEAGRSADEV LYHNQSSVKL GELERYVITY ELYQGDSIPA DITLDSLWVK IKNTTKLSYK
     PAYLLGPFIL YCDVRAKDYE SSYKIICSAD KPVFQSNLQA QQKFIAELSL HHIKPRYVWI
     VDIVSQILFN KETKVTFEIV VGNSKASLKR KIRCNDSLPD KACNILHTGL SVHRLTTADI
     WKVPRPIDMS QKSHLVILTH GFQSNVSADM EYLMEEIYKA QMNNPNERLV IKGYMKNACE
     TEKGIKFLGV GLANYIIDEL YDDSVGKISF IGHSLGGLTQ TFAICYIKTK YPYFFKKVEP
     INFISLASPL LGIATSTPNY VKMSLSMGII GTTGQELGLK DGNYGDKPLL YLLSEESLIS
     VLARFKRRTL YANAVNDGIV PLYSSSLLFL DYSQLLQKLG GQTTAPCDPL FQPEVSPIGE
     LPNHSDVAND DDGINASSWN TFWKSKENNC DKKSKRLMNA SVIKSMKSVL LSPCPDAKFF
     SDPDARVATI IHDKIYTEKN LPPPSPTLYE GTAAKEGETR KTRKEMEEII ARRWHKGMHW
     RKVVVLLKPD AHNNIIVRRR FSNAYGWPVV DHLVTAHFQR DDPIASPMQD KQFAEEDINM
     ATGGVEPNKF YSWLTKIEDP SVYHGGIVST ASQLASSWIS KHSSVTD