YD114_YEAST
ID YD114_YEAST Reviewed; 308 AA.
AC Q07530; D6VRN6;
DT 27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 148.
DE RecName: Full=Uncharacterized oxidoreductase YDL114W;
DE EC=1.-.-.-;
GN OrderedLocusNames=YDL114W;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169867;
RA Jacq C., Alt-Moerbe J., Andre B., Arnold W., Bahr A., Ballesta J.P.G.,
RA Bargues M., Baron L., Becker A., Biteau N., Bloecker H., Blugeon C.,
RA Boskovic J., Brandt P., Brueckner M., Buitrago M.J., Coster F.,
RA Delaveau T., del Rey F., Dujon B., Eide L.G., Garcia-Cantalejo J.M.,
RA Goffeau A., Gomez-Peris A., Granotier C., Hanemann V., Hankeln T.,
RA Hoheisel J.D., Jaeger W., Jimenez A., Jonniaux J.-L., Kraemer C.,
RA Kuester H., Laamanen P., Legros Y., Louis E.J., Moeller-Rieker S.,
RA Monnet A., Moro M., Mueller-Auer S., Nussbaumer B., Paricio N., Paulin L.,
RA Perea J., Perez-Alonso M., Perez-Ortin J.E., Pohl T.M., Prydz H.,
RA Purnelle B., Rasmussen S.W., Remacha M.A., Revuelta J.L., Rieger M.,
RA Salom D., Saluz H.P., Saiz J.E., Saren A.-M., Schaefer M., Scharfe M.,
RA Schmidt E.R., Schneider C., Scholler P., Schwarz S., Soler-Mira A.,
RA Urrestarazu L.A., Verhasselt P., Vissers S., Voet M., Volckaert G.,
RA Wagner G., Wambutt R., Wedler E., Wedler H., Woelfl S., Harris D.E.,
RA Bowman S., Brown D., Churcher C.M., Connor R., Dedman K., Gentles S.,
RA Hamlin N., Hunt S., Jones L., McDonald S., Murphy L.D., Niblett D.,
RA Odell C., Oliver K., Rajandream M.A., Richards C., Shore L., Walsh S.V.,
RA Barrell B.G., Dietrich F.S., Mulligan J.T., Allen E., Araujo R., Aviles E.,
RA Berno A., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M.,
RA Hunicke-Smith S., Hyman R.W., Komp C., Lashkari D., Lew H., Lin D.,
RA Mosedale D., Nakahara K., Namath A., Oefner P., Oh C., Petel F.X.,
RA Roberts D., Schramm S., Schroeder M., Shogren T., Shroff N., Winant A.,
RA Yelton M.A., Botstein D., Davis R.W., Johnston M., Andrews S., Brinkman R.,
RA Cooper J., Ding H., Du Z., Favello A., Fulton L., Gattung S., Greco T.,
RA Hallsworth K., Hawkins J., Hillier L.W., Jier M., Johnson D., Johnston L.,
RA Kirsten J., Kucaba T., Langston Y., Latreille P., Le T., Mardis E.,
RA Menezes S., Miller N., Nhan M., Pauley A., Peluso D., Rifkin L., Riles L.,
RA Taich A., Trevaskis E., Vignati D., Wilcox L., Wohldman P., Vaudin M.,
RA Wilson R., Waterston R., Albermann K., Hani J., Heumann K., Kleine K.,
RA Mewes H.-W., Zollner A., Zaccaria P.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome IV.";
RL Nature 387:75-78(1997).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
CC -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR)
CC family. {ECO:0000305}.
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DR EMBL; Z74162; CAA98682.1; -; Genomic_DNA.
DR EMBL; BK006938; DAA11746.1; -; Genomic_DNA.
DR PIR; S67657; S67657.
DR RefSeq; NP_010169.1; NM_001180173.1.
DR AlphaFoldDB; Q07530; -.
DR SMR; Q07530; -.
DR BioGRID; 31948; 42.
DR DIP; DIP-5029N; -.
DR IntAct; Q07530; 4.
DR STRING; 4932.YDL114W; -.
DR PaxDb; Q07530; -.
DR PRIDE; Q07530; -.
DR EnsemblFungi; YDL114W_mRNA; YDL114W; YDL114W.
DR GeneID; 851444; -.
DR KEGG; sce:YDL114W; -.
DR SGD; S000002272; YDL114W.
DR VEuPathDB; FungiDB:YDL114W; -.
DR eggNOG; KOG1201; Eukaryota.
DR GeneTree; ENSGT00940000169042; -.
DR HOGENOM; CLU_010194_5_1_1; -.
DR InParanoid; Q07530; -.
DR OMA; LCLRAQV; -.
DR BioCyc; YEAST:G3O-29514-MON; -.
DR Reactome; R-SCE-193144; Estrogen biosynthesis.
DR Reactome; R-SCE-2187335; The retinoid cycle in cones (daylight vision).
DR Reactome; R-SCE-5365859; RA biosynthesis pathway.
DR Reactome; R-SCE-8964572; Lipid particle organization.
DR PRO; PR:Q07530; -.
DR Proteomes; UP000002311; Chromosome IV.
DR RNAct; Q07530; protein.
DR GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IBA:GO_Central.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR020904; Sc_DH/Rdtase_CS.
DR InterPro; IPR002347; SDR_fam.
DR Pfam; PF00106; adh_short; 1.
DR PRINTS; PR00081; GDHRDH.
DR PRINTS; PR00080; SDRFAMILY.
DR SUPFAM; SSF51735; SSF51735; 1.
DR PROSITE; PS00061; ADH_SHORT; 1.
PE 3: Inferred from homology;
KW Oxidoreductase; Reference proteome.
FT CHAIN 1..308
FT /note="Uncharacterized oxidoreductase YDL114W"
FT /id="PRO_0000240705"
FT ACT_SITE 182
FT /note="Proton acceptor"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU10001"
FT BINDING 42..66
FT /ligand="NADP(+)"
FT /ligand_id="ChEBI:CHEBI:58349"
FT /evidence="ECO:0000250"
FT BINDING 169
FT /ligand="substrate"
FT /evidence="ECO:0000250"
SQ SEQUENCE 308 AA; 34295 MW; A5C14F950621ED09 CRC64;
MVRKNKINRA SGTTKHLKDF PSVILSLPSY NPSILSKNAT ALITGGSSGL GFELAKELSR
RINKVIVADI QSFPTFAQVE YNNIFYYQCD ITSLDEIKNL KKAIERDHGN INIIINNAGV
AHIKKLEHMT NKEVEQLIDI NLIGAYRIIS TFAEDMIDNR EGFIINIASV LGELTPARLT
SYGASKGAMI GFHKCMSRHF RSLSTECNKT GIKTLLVCPG KIKTNMFIDV PTPSKLLAPD
IIPSQLALAI ISAMEHNHLQ TLNAPYYVNL VPFFKTLSWP YRHLLKHFSG MDHVTSTSPR
AINPKRSA
