YD115_PLAF7
ID YD115_PLAF7 Reviewed; 1612 AA.
AC Q8IFN0;
DT 16-DEC-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 25-MAY-2022, entry version 65.
DE RecName: Full=Uncharacterized protein PFD1115c;
GN ORFNames=PFD1115c;
OS Plasmodium falciparum (isolate 3D7).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=36329;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=3D7;
RX PubMed=12368864; DOI=10.1038/nature01097;
RA Gardner M.J., Hall N., Fung E., White O., Berriman M., Hyman R.W.,
RA Carlton J.M., Pain A., Nelson K.E., Bowman S., Paulsen I.T., James K.D.,
RA Eisen J.A., Rutherford K.M., Salzberg S.L., Craig A., Kyes S., Chan M.-S.,
RA Nene V., Shallom S.J., Suh B., Peterson J., Angiuoli S., Pertea M.,
RA Allen J., Selengut J., Haft D., Mather M.W., Vaidya A.B., Martin D.M.A.,
RA Fairlamb A.H., Fraunholz M.J., Roos D.S., Ralph S.A., McFadden G.I.,
RA Cummings L.M., Subramanian G.M., Mungall C., Venter J.C., Carucci D.J.,
RA Hoffman S.L., Newbold C., Davis R.W., Fraser C.M., Barrell B.G.;
RT "Genome sequence of the human malaria parasite Plasmodium falciparum.";
RL Nature 419:498-511(2002).
RN [2] {ECO:0000312|EMBL:CAD49270.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=3D7;
RX PubMed=12368867; DOI=10.1038/nature01095;
RA Hall N., Pain A., Berriman M., Churcher C.M., Harris B., Harris D.,
RA Mungall K.L., Bowman S., Atkin R., Baker S., Barron A., Brooks K.,
RA Buckee C.O., Burrows C., Cherevach I., Chillingworth C., Chillingworth T.,
RA Christodoulou Z., Clark L., Clark R., Corton C., Cronin A., Davies R.M.,
RA Davis P., Dear P., Dearden F., Doggett J., Feltwell T., Goble A.,
RA Goodhead I., Gwilliam R., Hamlin N., Hance Z., Harper D., Hauser H.,
RA Hornsby T., Holroyd S., Horrocks P., Humphray S., Jagels K., James K.D.,
RA Johnson D., Kerhornou A., Knights A., Konfortov B., Kyes S., Larke N.,
RA Lawson D., Lennard N., Line A., Maddison M., Mclean J., Mooney P.,
RA Moule S., Murphy L., Oliver K., Ormond D., Price C., Quail M.A.,
RA Rabbinowitsch E., Rajandream M.A., Rutter S., Rutherford K.M., Sanders M.,
RA Simmonds M., Seeger K., Sharp S., Smith R., Squares R., Squares S.,
RA Stevens K., Taylor K., Tivey A., Unwin L., Whitehead S., Woodward J.R.,
RA Sulston J.E., Craig A., Newbold C., Barrell B.G.;
RT "Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.";
RL Nature 419:527-531(2002).
RN [3] {ECO:0000305}
RP SYNTHESIS OF 780-862, DEVELOPMENTAL STAGE, AND POSSIBLE CANDIDATE MALARIA
RP EPITOPE.
RX PubMed=17653272; DOI=10.1371/journal.pone.0000645;
RA Villard V., Agak G.W., Frank G., Jafarshad A., Servis C., Nebie I.,
RA Sirima S.B., Felger I., Arevalo-Herrera M., Herrera S., Heitz F.,
RA Baecker V., Druilhe P., Kajava A.V., Corradin G.;
RT "Rapid identification of malaria vaccine candidates based on alpha-helical
RT coiled coil protein motif.";
RL PLoS ONE 2:E645-E645(2007).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass membrane
CC protein {ECO:0000255}.
CC -!- DEVELOPMENTAL STAGE: Expressed during the asexual cell-cycle on the
CC cell surface of the host erythrocytes. {ECO:0000269|PubMed:17653272}.
CC -!- BIOTECHNOLOGY: Possible candidate for an effective malaria vaccine as
CC determined by epitope response in sera. {ECO:0000269|PubMed:17653272}.
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DR EMBL; AL844503; CAD49270.1; -; Genomic_DNA.
DR RefSeq; XP_001351539.1; XM_001351503.1.
DR AlphaFoldDB; Q8IFN0; -.
DR BioGRID; 1207776; 1.
DR IntAct; Q8IFN0; 1.
DR PRIDE; Q8IFN0; -.
DR EnsemblProtists; CAD49270; CAD49270; PF3D7_0423600.
DR GeneID; 812438; -.
DR KEGG; pfa:PF3D7_0423600; -.
DR VEuPathDB; PlasmoDB:PF3D7_0423600; -.
DR HOGENOM; CLU_256535_0_0_1; -.
DR InParanoid; Q8IFN0; -.
DR OMA; VFKFRLA; -.
DR PhylomeDB; Q8IFN0; -.
DR Proteomes; UP000001450; Chromosome 4.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
PE 1: Evidence at protein level;
KW Coiled coil; Membrane; Merozoite; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..1612
FT /note="Uncharacterized protein PFD1115c"
FT /id="PRO_0000356831"
FT TRANSMEM 479..499
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 46..94
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 369..400
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 698..777
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 992..1037
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1091..1157
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1257..1291
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1554..1612
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 23..52
FT /evidence="ECO:0000255"
FT COILED 1338..1362
FT /evidence="ECO:0000255"
FT COILED 1444..1469
FT /evidence="ECO:0000255"
FT COILED 1553..1601
FT /evidence="ECO:0000255"
FT COMPBIAS 376..400
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 997..1034
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1554..1572
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1573..1598
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1612 AA; 190947 MW; F00A408EB4521D07 CRC64;
MNLLRKKVKN EKSLSTLLIN EEENKNIEMT TLKDKKEMKN ENLSKINVKK ENHDKNHDKN
HDKNHDKNHD KNHDKNHDKN HDKNHDKNHD KNHVKNNVEY YNDVFTHLYN CDDGGEEPKE
YSHKKKQVNN KKKWKKQYKA VKLYMNMFLN NYKLKKGKGN CKNLSSVKKR RKKKKIIQND
YIRIINAEKE YVQKYHEDKI FLDNIKNVSS CELIKDCSYS VFFYNLFIKG LYLNKQNLEH
ATEKEHIQKN ITKNITKNEL HINKTSEHVS NITKLKKNYN KHNVILFKGK YTRQLICDYL
KFLLNSIQNE HTIKAHFYIL DYVNDLENKK KEMAKKIKME SFIFTNSNEE DKLCKDIILN
CNILNEQKED DNKSDNPLYS NNNTLKEQNT STPLPSHEIQ TESMNSPNLL NVKNMNQTKD
DNGCTKEEII KSNNLMKTYD IKINEHIYNK ILNNFISELK SFFFSILEKI RSSKLLLRFI
VTLSEICLIL TPHYVNIINF IEILCDFGHI IPIHYISHFI HFFQCNKNIF IQKYKEFQHC
IINNDPIKIQ SVGARLIGFI KILQKKIHLN NNEQSMYSFF LNLLLSECLP INHLGFCNRQ
SAKNNFHYFF QESLDCCYKK FKEEQILYDN FELNIQNNIK NYKKIKTIIE HEIELNSDKY
LIKEEDENFI SAKNVISDEQ DGEDTLYKKR KREEFKETSL TKKKQKKKND EIKKTGEEKK
KTGEEKKKTG EEKKKTGEEK KKTGEEKKKT GEEKKKTGEE KKKTGEEKKK TGEEKKLTND
VTHLTNDVTH LTNDVTHLTN DVTHLTNDVT HLTNDVTHLT NDVTHLTNDV THLTNDVTHL
TNDVTHLTND VTHLTNDVTH LTNEKYIEEK DTKEMYLSYM SFISLVAFIK YPEIITQDNI
ILVEDVYNSF KTFLNYINSL EKEKKENFKR TKKYMNMIKA YLFNDHIDIL ANVHIFKVLV
YDENFLRVLF FNILVVLNYL NRELQICVKD DNELDNNNNK NNNNNKNNNN NKNNNNNNNN
NNNNNNNNDN GVKKNDPAII SPRSSFLFFV EYDKNDDHEL GDPEKINNHL NGLMTRGHQK
SIRENIKNKE SGKSSILTTG TSNNNNNVNN MNNNMNNNMN NNMNNHMNSN NNVVDSNSTN
FKENVKNKDN SNNRNMSVNQ NILHNKTKDI KFCKENDDKF VIKEKIKKIM FTFVKELLNY
LDGFINSNHN FMLAKEYSWY VWKKQLNVAK YNKDDYDISF KFKCIDENIK EQNYDINQTT
NNNTYNNQTS NHMNENLHTD ESSKSNNNQD KTVYTNEVSY LPNIPKKNKK TDNQSPVQTL
INIIQNFELL NKKMKPFYCN NKNKNKNKNK NKNKNMEQIN NKDITMNLCN NNNNIIHNKE
QDNIQQHDDN NIINTNNDQS SYNNDIFHIN NFLLEINKIY LRREAEFWEL DESDSLTDEK
KNDSNKKILI EKLIDKLDDY KKKINIDNDP INEIEENEKS KNNPVFKFRL SKLFILKYID
LYTIVKNKEF TTDCDFLYNL MIQMDKNVEK KKSLLNKGVV ENDEDINVEH HINMEDEKNE
KLNDKEGEYE DVTENLNEQE AEEEAEEEAE EEEEEEDKFL TPEHLPINVE IK
