CB072_MOUSE
ID CB072_MOUSE Reviewed; 286 AA.
AC Q9CYS6; B2RPZ8;
DT 10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT 05-APR-2011, sequence version 2.
DT 03-AUG-2022, entry version 110.
DE RecName: Full=Uncharacterized protein C2orf72 homolog;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 103-286 (ISOFORM 2).
RC STRAIN=C57BL/6J;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9CYS6-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9CYS6-2; Sequence=VSP_040798;
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB28812.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; BC137675; AAI37676.1; -; mRNA.
DR EMBL; AK013367; BAB28812.1; ALT_INIT; mRNA.
DR CCDS; CCDS48302.1; -. [Q9CYS6-2]
DR CCDS; CCDS78641.1; -. [Q9CYS6-1]
DR RefSeq; NP_001138465.1; NM_001144993.1. [Q9CYS6-1]
DR AlphaFoldDB; Q9CYS6; -.
DR IntAct; Q9CYS6; 1.
DR MINT; Q9CYS6; -.
DR iPTMnet; Q9CYS6; -.
DR PhosphoSitePlus; Q9CYS6; -.
DR SwissPalm; Q9CYS6; -.
DR jPOST; Q9CYS6; -.
DR MaxQB; Q9CYS6; -.
DR PaxDb; Q9CYS6; -.
DR PRIDE; Q9CYS6; -.
DR Antibodypedia; 50518; 13 antibodies from 7 providers.
DR Ensembl; ENSMUST00000027429; ENSMUSP00000027429; ENSMUSG00000026227. [Q9CYS6-1]
DR Ensembl; ENSMUST00000165824; ENSMUSP00000131459; ENSMUSG00000026227. [Q9CYS6-2]
DR GeneID; 72792; -.
DR KEGG; mmu:72792; -.
DR UCSC; uc011wog.1; mouse. [Q9CYS6-1]
DR MGI; MGI:1920042; 2810459M11Rik.
DR VEuPathDB; HostDB:ENSMUSG00000026227; -.
DR eggNOG; ENOG502S7XX; Eukaryota.
DR GeneTree; ENSGT00390000003006; -.
DR HOGENOM; CLU_939971_0_0_1; -.
DR InParanoid; Q9CYS6; -.
DR OMA; PWSRGKN; -.
DR TreeFam; TF339232; -.
DR BioGRID-ORCS; 72792; 5 hits in 70 CRISPR screens.
DR PRO; PR:Q9CYS6; -.
DR Proteomes; UP000000589; Chromosome 1.
DR RNAct; Q9CYS6; protein.
DR Bgee; ENSMUSG00000026227; Expressed in left lobe of liver and 105 other tissues.
DR ExpressionAtlas; Q9CYS6; baseline and differential.
DR Genevisible; Q9CYS6; MM.
DR InterPro; IPR027868; DUF4630.
DR Pfam; PF15443; DUF4630; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Reference proteome.
FT CHAIN 1..286
FT /note="Uncharacterized protein C2orf72 homolog"
FT /id="PRO_0000339301"
FT REGION 59..89
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 225..286
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 227..242
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 203
FT /note="P -> PA (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_040798"
SQ SEQUENCE 286 AA; 30320 MW; 7B9F6CAF39BFB4F6 CRC64;
MESELEALAP RPASPAEPPF QALVEAAGGR GQVLLVGELW EREQSRALLR DFAGAVFPPE
SAPGKPGCAE AESAGTAAAT ESHGAPGAKA ERAIRSPLVF VLCRVGSLTS RESRRRLREM
LRDVRDRRCE GAALVGVLVA DTGADDARAP ELQLLETLLR TVFGRQVGGP VQAAAFRPGC
PASSLAVQEA ACRALQAAGP GRPEGAWERP ARTGLLTCFS WGPRRQRKNR GVTSSQGPAQ
EHLQFSEEEL ALTPVFPNGD CEDRGNGSRA QDGGVHIPPD PPEDTR
