ID   YD149_YEAST             Reviewed;         235 AA.
AC   A0A023PXH9;
DT   26-NOV-2014, integrated into UniProtKB/Swiss-Prot.
DT   09-JUL-2014, sequence version 1.
DT   25-MAY-2022, entry version 17.
DE   RecName: Full=Putative uncharacterized membrane protein YDR149C {ECO:0000305};
GN   OrderedLocusNames=YDR149C {ECO:0000312|SGD:S000002556};
OS   Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=559292;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=9169867;
RA   Jacq C., Alt-Moerbe J., Andre B., Arnold W., Bahr A., Ballesta J.P.G.,
RA   Bargues M., Baron L., Becker A., Biteau N., Bloecker H., Blugeon C.,
RA   Boskovic J., Brandt P., Brueckner M., Buitrago M.J., Coster F.,
RA   Delaveau T., del Rey F., Dujon B., Eide L.G., Garcia-Cantalejo J.M.,
RA   Goffeau A., Gomez-Peris A., Granotier C., Hanemann V., Hankeln T.,
RA   Hoheisel J.D., Jaeger W., Jimenez A., Jonniaux J.-L., Kraemer C.,
RA   Kuester H., Laamanen P., Legros Y., Louis E.J., Moeller-Rieker S.,
RA   Monnet A., Moro M., Mueller-Auer S., Nussbaumer B., Paricio N., Paulin L.,
RA   Perea J., Perez-Alonso M., Perez-Ortin J.E., Pohl T.M., Prydz H.,
RA   Purnelle B., Rasmussen S.W., Remacha M.A., Revuelta J.L., Rieger M.,
RA   Salom D., Saluz H.P., Saiz J.E., Saren A.-M., Schaefer M., Scharfe M.,
RA   Schmidt E.R., Schneider C., Scholler P., Schwarz S., Soler-Mira A.,
RA   Urrestarazu L.A., Verhasselt P., Vissers S., Voet M., Volckaert G.,
RA   Wagner G., Wambutt R., Wedler E., Wedler H., Woelfl S., Harris D.E.,
RA   Bowman S., Brown D., Churcher C.M., Connor R., Dedman K., Gentles S.,
RA   Hamlin N., Hunt S., Jones L., McDonald S., Murphy L.D., Niblett D.,
RA   Odell C., Oliver K., Rajandream M.A., Richards C., Shore L., Walsh S.V.,
RA   Barrell B.G., Dietrich F.S., Mulligan J.T., Allen E., Araujo R., Aviles E.,
RA   Berno A., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M.,
RA   Hunicke-Smith S., Hyman R.W., Komp C., Lashkari D., Lew H., Lin D.,
RA   Mosedale D., Nakahara K., Namath A., Oefner P., Oh C., Petel F.X.,
RA   Roberts D., Schramm S., Schroeder M., Shogren T., Shroff N., Winant A.,
RA   Yelton M.A., Botstein D., Davis R.W., Johnston M., Andrews S., Brinkman R.,
RA   Cooper J., Ding H., Du Z., Favello A., Fulton L., Gattung S., Greco T.,
RA   Hallsworth K., Hawkins J., Hillier L.W., Jier M., Johnson D., Johnston L.,
RA   Kirsten J., Kucaba T., Langston Y., Latreille P., Le T., Mardis E.,
RA   Menezes S., Miller N., Nhan M., Pauley A., Peluso D., Rifkin L., Riles L.,
RA   Taich A., Trevaskis E., Vignati D., Wilcox L., Wohldman P., Vaudin M.,
RA   Wilson R., Waterston R., Albermann K., Hani J., Heumann K., Kleine K.,
RA   Mewes H.-W., Zollner A., Zaccaria P.;
RT   "The nucleotide sequence of Saccharomyces cerevisiae chromosome IV.";
RL   Nature 387:75-78(1997).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=24374639; DOI=10.1534/g3.113.008995;
RA   Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA   Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA   Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT   "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL   G3 (Bethesda) 4:389-398(2014).
RN   [3]
RP   DISRUPTION PHENOTYPE.
RX   PubMed=16630279; DOI=10.1111/j.1567-1364.2005.00007.x;
RA   Snoek I.S., Steensma H.Y.;
RT   "Why does Kluyveromyces lactis not grow under anaerobic conditions?
RT   Comparison of essential anaerobic genes of Saccharomyces cerevisiae with
RT   the Kluyveromyces lactis genome.";
RL   FEMS Yeast Res. 6:393-403(2006).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane
CC       protein {ECO:0000255}.
CC   -!- DISRUPTION PHENOTYPE: Cannot grow under anaerobic growth conditions.
CC       {ECO:0000269|PubMed:16630279}.
CC   -!- MISCELLANEOUS: Partially overlaps NUM1. Disruption phenotypes caused by
CC       deletion of this gene may also be a result of a defect in its
CC       overlapping gene. {ECO:0000305}.
CC   -!- CAUTION: Product of a dubious gene prediction unlikely to encode a
CC       functional protein. Because of that it is not part of the S.cerevisiae
CC       S288c complete/reference proteome set. {ECO:0000305|PubMed:24374639}.
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DR   EMBL; KJ412217; AHX39260.1; -; Genomic_DNA.
DR   PIR; S69757; S69757.
DR   AlphaFoldDB; A0A023PXH9; -.
DR   STRING; 4932.YDR149C; -.
DR   PaxDb; A0A023PXH9; -.
DR   EnsemblFungi; YDR149C_mRNA; YDR149C; YDR149C.
DR   SGD; S000002556; YDR149C.
DR   HOGENOM; CLU_1397069_0_0_1; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
PE   5: Uncertain;
KW   Membrane; Transmembrane; Transmembrane helix.
FT   CHAIN           1..235
FT                   /note="Putative uncharacterized membrane protein YDR149C"
FT                   /id="PRO_0000430981"
FT   TRANSMEM        167..187
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        190..210
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   235 AA;  27059 MW;  418956B69F802A1C CRC64;
     MPFFVNVKIS KSVFRSFRLS FSSFQDFSVF FFNSFNCLHS MLKFVNLDSK SQFKSLVESN
     SFMKDFFWLV SSSILSLNDS LICLRDLICS FLASLEDCNF LHSTNKFSLS SKVKFISFDE
     FAVSTPLWEL LPANSGSTSF VSLLLKILEI ENRFVLSPSS PLPHSSAFKL AILVTPFVET
     LSWLNELSML FAYCPAELSL SLFFLCLLLW DIFERLVESL DRCVFTRLYS TLWSY