CB074_HUMAN
ID CB074_HUMAN Reviewed; 187 AA.
AC A8MZ97; C9JP62;
DT 01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT 23-FEB-2022, sequence version 4.
DT 03-AUG-2022, entry version 91.
DE RecName: Full=Uncharacterized protein C2orf74;
GN Name=C2orf74;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
CC -!- INTERACTION:
CC A8MZ97; Q0VAQ4: SMAGP; NbExp=3; IntAct=EBI-3943880, EBI-10226799;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AC016747; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; NP_001137431.1; NM_001143959.1.
DR AlphaFoldDB; A8MZ97; -.
DR BioGRID; 130940; 2.
DR IntAct; A8MZ97; 2.
DR STRING; 9606.ENSP00000402915; -.
DR iPTMnet; A8MZ97; -.
DR PhosphoSitePlus; A8MZ97; -.
DR BioMuta; C2orf74; -.
DR EPD; A8MZ97; -.
DR MassIVE; A8MZ97; -.
DR MaxQB; A8MZ97; -.
DR PaxDb; A8MZ97; -.
DR PeptideAtlas; A8MZ97; -.
DR PRIDE; A8MZ97; -.
DR ProteomicsDB; 2463; -.
DR Antibodypedia; 48106; 19 antibodies from 13 providers.
DR DNASU; 339804; -.
DR Ensembl; ENST00000432605.3; ENSP00000402915.2; ENSG00000237651.8.
DR GeneID; 339804; -.
DR KEGG; hsa:339804; -.
DR MANE-Select; ENST00000432605.3; ENSP00000402915.2; NM_001143959.4; NP_001137431.2.
DR UCSC; uc010ypm.1; human.
DR CTD; 339804; -.
DR DisGeNET; 339804; -.
DR GeneCards; C2orf74; -.
DR HGNC; HGNC:34439; C2orf74.
DR HPA; ENSG00000237651; Low tissue specificity.
DR neXtProt; NX_A8MZ97; -.
DR OpenTargets; ENSG00000237651; -.
DR PharmGKB; PA162379547; -.
DR VEuPathDB; HostDB:ENSG00000237651; -.
DR eggNOG; ENOG502TF2B; Eukaryota.
DR GeneTree; ENSGT00390000004911; -.
DR HOGENOM; CLU_1351712_0_0_1; -.
DR InParanoid; A8MZ97; -.
DR OMA; YKCSQSR; -.
DR OrthoDB; 989516at2759; -.
DR PhylomeDB; A8MZ97; -.
DR PathwayCommons; A8MZ97; -.
DR SignaLink; A8MZ97; -.
DR BioGRID-ORCS; 339804; 4 hits in 178 CRISPR screens.
DR ChiTaRS; C2orf74; human.
DR GenomeRNAi; 339804; -.
DR Pharos; A8MZ97; Tdark.
DR PRO; PR:A8MZ97; -.
DR Proteomes; UP000005640; Chromosome 2.
DR RNAct; A8MZ97; protein.
DR Bgee; ENSG00000237651; Expressed in nucleus accumbens and 98 other tissues.
DR ExpressionAtlas; A8MZ97; baseline and differential.
DR Genevisible; A8MZ97; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR027813; DUF4642.
DR PANTHER; PTHR37882; PTHR37882; 1.
DR Pfam; PF15484; DUF4642; 1.
PE 1: Evidence at protein level;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..187
FT /note="Uncharacterized protein C2orf74"
FT /id="PRO_0000343566"
FT TRANSMEM 8..28
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 99..153
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 99..137
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 187 AA; 21174 MW; B25D87257B6CFC9F CRC64;
MSFETTAITF FIILLICLIC ILLLLVVFLY KCFQGRKGKE TKKVPCTDAN GGVDCAAAKV
VTSNPEDHER ILMQVMNLNV PMRPGILVQR QSKEVLATPL ENRRDMEAEE ENQINEKQEP
ENAGETGQEE DDGLQKIHTS VTRTPSVVES QKRPLKGVTF SREVIVVDLG NEYPTPRSYT
REHKERK
