CB074_MOUSE
ID CB074_MOUSE Reviewed; 196 AA.
AC Q810S2; Q9D9C4; Q9D9E2;
DT 01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 03-AUG-2022, entry version 101.
DE RecName: Full=Uncharacterized protein C2orf74 homolog;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB24840.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305};
CC Sequence=BAB24869.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AK007052; BAB24840.1; ALT_SEQ; mRNA.
DR EMBL; AK007139; BAB24869.1; ALT_INIT; mRNA.
DR EMBL; AL672049; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC049567; AAH49567.1; -; mRNA.
DR RefSeq; NP_001103603.1; NM_001110133.1.
DR RefSeq; NP_080381.2; NM_026105.3.
DR RefSeq; XP_006514852.1; XM_006514789.2.
DR RefSeq; XP_006514853.1; XM_006514790.2.
DR AlphaFoldDB; Q810S2; -.
DR SMR; Q810S2; -.
DR STRING; 10090.ENSMUSP00000020527; -.
DR PhosphoSitePlus; Q810S2; -.
DR PaxDb; Q810S2; -.
DR PRIDE; Q810S2; -.
DR Antibodypedia; 48106; 19 antibodies from 13 providers.
DR DNASU; 67358; -.
DR Ensembl; ENSMUST00000169264; ENSMUSP00000131204; ENSMUSG00000020286.
DR Ensembl; ENSMUST00000239488; ENSMUSP00000159376; ENSMUSG00000020286.
DR GeneID; 67358; -.
DR KEGG; mmu:67358; -.
DR UCSC; uc007ife.1; mouse.
DR MGI; MGI:1914608; 1700093K21Rik.
DR VEuPathDB; HostDB:ENSMUSG00000020286; -.
DR eggNOG; ENOG502TF2B; Eukaryota.
DR GeneTree; ENSGT00390000004911; -.
DR HOGENOM; CLU_1351712_0_0_1; -.
DR InParanoid; Q810S2; -.
DR OrthoDB; 1467634at2759; -.
DR PhylomeDB; Q810S2; -.
DR BioGRID-ORCS; 67358; 2 hits in 71 CRISPR screens.
DR PRO; PR:Q810S2; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; Q810S2; protein.
DR Bgee; ENSMUSG00000020286; Expressed in seminiferous tubule of testis and 20 other tissues.
DR ExpressionAtlas; Q810S2; baseline and differential.
DR Genevisible; Q810S2; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR027813; DUF4642.
DR PANTHER; PTHR37882; PTHR37882; 1.
DR Pfam; PF15484; DUF4642; 1.
PE 2: Evidence at transcript level;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..196
FT /note="Uncharacterized protein C2orf74 homolog"
FT /id="PRO_0000343567"
FT TRANSMEM 26..46
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CONFLICT 71
FT /note="A -> D (in Ref. 1; BAB24840)"
FT /evidence="ECO:0000305"
FT CONFLICT 138
FT /note="N -> H (in Ref. 1; BAB24840)"
FT /evidence="ECO:0000305"
FT CONFLICT 172
FT /note="E -> K (in Ref. 1; BAB24840)"
FT /evidence="ECO:0000305"
FT CONFLICT 179
FT /note="G -> V (in Ref. 1; BAB24840)"
FT /evidence="ECO:0000305"
FT CONFLICT 186
FT /note="R -> L (in Ref. 1; BAB24840)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 196 AA; 22381 MW; A554B654522CB58F CRC64;
MFTQSDTGKI EEIFTTNTMA FETTAITFFF ILLICFICIL LLLAIFLYKC YRGHNHEEPL
KTLCTGEGCV AANAEMDKPE DQDKVLMHFL NMGLPMKPSI LVQKQSKEEM ATSLGDNIKA
EDYQKKQTYE PVNARETNHE GELAEKMPIH VHRSSDTGSQ KRPLKGVTFS KEVIVVDLGN
EYPTPRSYAR EHKERK
