CB076_MOUSE
ID CB076_MOUSE Reviewed; 126 AA.
AC Q9CRW3; Q8K163;
DT 18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT 18-MAR-2008, sequence version 2.
DT 03-AUG-2022, entry version 106.
DE RecName: Full=UPF0538 protein C2orf76 homolog;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=C57BL/6J; TISSUE=Head;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J; TISSUE=Head;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=C57BL/6J; TISSUE=Thymus;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9CRW3-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9CRW3-2; Sequence=VSP_032430;
CC -!- SIMILARITY: Belongs to the UPF0538 family. {ECO:0000305}.
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DR EMBL; AK014026; BAB29121.1; -; mRNA.
DR EMBL; AC139867; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC028767; AAH28767.1; -; mRNA.
DR CCDS; CCDS15232.1; -. [Q9CRW3-1]
DR CCDS; CCDS48342.1; -. [Q9CRW3-2]
DR RefSeq; NP_001165545.1; NM_001172074.1. [Q9CRW3-2]
DR RefSeq; NP_082715.1; NM_028439.2. [Q9CRW3-1]
DR AlphaFoldDB; Q9CRW3; -.
DR STRING; 10090.ENSMUSP00000108263; -.
DR PhosphoSitePlus; Q9CRW3; -.
DR EPD; Q9CRW3; -.
DR MaxQB; Q9CRW3; -.
DR PaxDb; Q9CRW3; -.
DR PRIDE; Q9CRW3; -.
DR DNASU; 73103; -.
DR Ensembl; ENSMUST00000027637; ENSMUSP00000027637; ENSMUSG00000026388. [Q9CRW3-2]
DR Ensembl; ENSMUST00000056038; ENSMUSP00000053335; ENSMUSG00000026388. [Q9CRW3-2]
DR Ensembl; ENSMUST00000112644; ENSMUSP00000108263; ENSMUSG00000026388. [Q9CRW3-1]
DR GeneID; 73103; -.
DR KEGG; mmu:73103; -.
DR UCSC; uc007cjg.1; mouse. [Q9CRW3-2]
DR UCSC; uc007cjh.2; mouse. [Q9CRW3-1]
DR MGI; MGI:1920353; 3110009E18Rik.
DR VEuPathDB; HostDB:ENSMUSG00000026388; -.
DR eggNOG; KOG4147; Eukaryota.
DR HOGENOM; CLU_2037306_0_0_1; -.
DR InParanoid; Q9CRW3; -.
DR OMA; YRNVKNH; -.
DR OrthoDB; 1568647at2759; -.
DR PhylomeDB; Q9CRW3; -.
DR TreeFam; TF300221; -.
DR BioGRID-ORCS; 73103; 6 hits in 74 CRISPR screens.
DR PRO; PR:Q9CRW3; -.
DR Proteomes; UP000000589; Chromosome 1.
DR RNAct; Q9CRW3; protein.
DR Bgee; ENSMUSG00000026388; Expressed in animal zygote and 250 other tissues.
DR ExpressionAtlas; Q9CRW3; baseline and differential.
DR Genevisible; Q9CRW3; MM.
DR InterPro; IPR018794; UPF0538.
DR PANTHER; PTHR18444; PTHR18444; 1.
DR Pfam; PF10209; DUF2340; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Reference proteome.
FT CHAIN 1..126
FT /note="UPF0538 protein C2orf76 homolog"
FT /id="PRO_0000325825"
FT VAR_SEQ 75..126
FT /note="TNELVLGLEDDDTLLLKEDRTLKDSGVASETEIAFFCGEDYKRYKANPISSW
FT -> PVKLKLHSSVEKIISDTKLIPSRPGESGCGPLFHKFCFFINCQINLF (in
FT isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_032430"
SQ SEQUENCE 126 AA; 14588 MW; 9D0B7B0E17741F20 CRC64;
MAAEEATLTV RLIRSFEHRN FKPVVYHGVN LHQTVKEFII FLKQDVPLRT SLPPPLRNYK
YDTLKILHQA HKAKTNELVL GLEDDDTLLL KEDRTLKDSG VASETEIAFF CGEDYKRYKA
NPISSW
