YD444_YEAST
ID YD444_YEAST Reviewed; 687 AA.
AC Q04093; D6VT70;
DT 17-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 150.
DE RecName: Full=Putative lipase YDR444W;
DE EC=3.1.-.-;
GN OrderedLocusNames=YDR444W;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169867;
RA Jacq C., Alt-Moerbe J., Andre B., Arnold W., Bahr A., Ballesta J.P.G.,
RA Bargues M., Baron L., Becker A., Biteau N., Bloecker H., Blugeon C.,
RA Boskovic J., Brandt P., Brueckner M., Buitrago M.J., Coster F.,
RA Delaveau T., del Rey F., Dujon B., Eide L.G., Garcia-Cantalejo J.M.,
RA Goffeau A., Gomez-Peris A., Granotier C., Hanemann V., Hankeln T.,
RA Hoheisel J.D., Jaeger W., Jimenez A., Jonniaux J.-L., Kraemer C.,
RA Kuester H., Laamanen P., Legros Y., Louis E.J., Moeller-Rieker S.,
RA Monnet A., Moro M., Mueller-Auer S., Nussbaumer B., Paricio N., Paulin L.,
RA Perea J., Perez-Alonso M., Perez-Ortin J.E., Pohl T.M., Prydz H.,
RA Purnelle B., Rasmussen S.W., Remacha M.A., Revuelta J.L., Rieger M.,
RA Salom D., Saluz H.P., Saiz J.E., Saren A.-M., Schaefer M., Scharfe M.,
RA Schmidt E.R., Schneider C., Scholler P., Schwarz S., Soler-Mira A.,
RA Urrestarazu L.A., Verhasselt P., Vissers S., Voet M., Volckaert G.,
RA Wagner G., Wambutt R., Wedler E., Wedler H., Woelfl S., Harris D.E.,
RA Bowman S., Brown D., Churcher C.M., Connor R., Dedman K., Gentles S.,
RA Hamlin N., Hunt S., Jones L., McDonald S., Murphy L.D., Niblett D.,
RA Odell C., Oliver K., Rajandream M.A., Richards C., Shore L., Walsh S.V.,
RA Barrell B.G., Dietrich F.S., Mulligan J.T., Allen E., Araujo R., Aviles E.,
RA Berno A., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M.,
RA Hunicke-Smith S., Hyman R.W., Komp C., Lashkari D., Lew H., Lin D.,
RA Mosedale D., Nakahara K., Namath A., Oefner P., Oh C., Petel F.X.,
RA Roberts D., Schramm S., Schroeder M., Shogren T., Shroff N., Winant A.,
RA Yelton M.A., Botstein D., Davis R.W., Johnston M., Andrews S., Brinkman R.,
RA Cooper J., Ding H., Du Z., Favello A., Fulton L., Gattung S., Greco T.,
RA Hallsworth K., Hawkins J., Hillier L.W., Jier M., Johnson D., Johnston L.,
RA Kirsten J., Kucaba T., Langston Y., Latreille P., Le T., Mardis E.,
RA Menezes S., Miller N., Nhan M., Pauley A., Peluso D., Rifkin L., Riles L.,
RA Taich A., Trevaskis E., Vignati D., Wilcox L., Wohldman P., Vaudin M.,
RA Wilson R., Waterston R., Albermann K., Hani J., Heumann K., Kleine K.,
RA Mewes H.-W., Zollner A., Zaccaria P.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome IV.";
RL Nature 387:75-78(1997).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [3]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=14562095; DOI=10.1038/nature02026;
RA Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W.,
RA Weissman J.S., O'Shea E.K.;
RT "Global analysis of protein localization in budding yeast.";
RL Nature 425:686-691(2003).
RN [4]
RP LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX PubMed=14562106; DOI=10.1038/nature02046;
RA Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA O'Shea E.K., Weissman J.S.;
RT "Global analysis of protein expression in yeast.";
RL Nature 425:737-741(2003).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=18407956; DOI=10.1074/mcp.m700468-mcp200;
RA Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
RT "A multidimensional chromatography technology for in-depth phosphoproteome
RT analysis.";
RL Mol. Cell. Proteomics 7:1389-1396(2008).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:14562095}.
CC -!- MISCELLANEOUS: Present with 2070 molecules/cell in log phase SD medium.
CC {ECO:0000269|PubMed:14562106}.
CC -!- SIMILARITY: Belongs to the putative lipase ROG1 family. {ECO:0000305}.
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DR EMBL; U33007; AAB64869.1; -; Genomic_DNA.
DR EMBL; BK006938; DAA12280.1; -; Genomic_DNA.
DR PIR; S69723; S69723.
DR RefSeq; NP_010732.1; NM_001180752.1.
DR AlphaFoldDB; Q04093; -.
DR BioGRID; 32499; 39.
DR DIP; DIP-4736N; -.
DR MINT; Q04093; -.
DR STRING; 4932.YDR444W; -.
DR ESTHER; yeast-YDR444W; Duf_676.
DR iPTMnet; Q04093; -.
DR MaxQB; Q04093; -.
DR PaxDb; Q04093; -.
DR PRIDE; Q04093; -.
DR EnsemblFungi; YDR444W_mRNA; YDR444W; YDR444W.
DR GeneID; 852054; -.
DR KEGG; sce:YDR444W; -.
DR SGD; S000002852; YDR444W.
DR VEuPathDB; FungiDB:YDR444W; -.
DR eggNOG; KOG4372; Eukaryota.
DR HOGENOM; CLU_007367_1_0_1; -.
DR InParanoid; Q04093; -.
DR OMA; FSNIGCD; -.
DR BioCyc; YEAST:G3O-29976-MON; -.
DR PRO; PR:Q04093; -.
DR Proteomes; UP000002311; Chromosome IV.
DR RNAct; Q04093; protein.
DR GO; GO:0005737; C:cytoplasm; HDA:SGD.
DR GO; GO:0047372; F:acylglycerol lipase activity; IBA:GO_Central.
DR GO; GO:0044255; P:cellular lipid metabolic process; IBA:GO_Central.
DR GO; GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.1820; -; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR007751; DUF676_lipase-like.
DR InterPro; IPR044294; Lipase-like.
DR InterPro; IPR034315; Put_lipase_YDR444W.
DR InterPro; IPR016445; Rog1_fam.
DR PANTHER; PTHR12482; PTHR12482; 1.
DR PANTHER; PTHR12482:SF20; PTHR12482:SF20; 1.
DR Pfam; PF05057; DUF676; 1.
DR PIRSF; PIRSF005412; UCP005412_abhydr; 1.
DR SUPFAM; SSF53474; SSF53474; 1.
DR PROSITE; PS00120; LIPASE_SER; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Hydrolase; Lipid degradation; Lipid metabolism;
KW Reference proteome.
FT CHAIN 1..687
FT /note="Putative lipase YDR444W"
FT /id="PRO_0000253824"
FT REGION 429..472
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 491..513
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 650..687
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 436..467
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 494..512
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 650..666
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 284
FT /note="Charge relay system"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU10037"
SQ SEQUENCE 687 AA; 78108 MW; E856FAC40CBCBF07 CRC64;
MPYKINRMKN SLEINETGGT LLVDERKRLR IGELYRYKFS VNKDVIKEQG LDVSHLFLRI
KNEESALLRP LYLTGPYSFY IDVRPHNYNE NRKFPGKEII PFVENLKPDE RFKVKILLNE
NSRVGDTSLY SWTIDIISQL AVTTIPKLEF SFRIGTTRKV VKKSNGLFKS IEGVSLEMWD
TETLWDLPPK FPEKPVHLVI MTHGIFSNIG CDMLYMKDKI EEMTFPMDES INPNIIVRGF
MGNVGKSGHG IHCLGVRVGK YVLETVDKLN KKYKVDRISF IGHSLGGPTQ SMAVRYISIK
RPDFFDAVKG VKPVNFITLA SPFIGVIGDF PFYLSVPLDM GALGLTGRDL NLKYTPLTSK
DGLYADDEVY PEHSKYILEI LPQAPAKKVF ESFKRRTIYA NVMDDGIVPL RTAALLYLDW
RSIHKVQKIR KKNKNSPTSS EFVSSDSPES SGASSPSNEN GNNVGEIPAE SPNKKATLQW
TLPQAVIHGS KINKYKRGQT NEANSDSDNE QGVFLDGQKF EPPKEANTVL SALSVLTAAI
PDQEYIKNPA VRKDEVIHDK LYHPEELPPP HYENRPIVKK LIYPNESVNR IQERIAREWQ
ETMTWRKVLV QIQPDSHNNI VVRRRFVNLY GYVAVEHMVE HHFGSKVCSE LAEDANEPKD
EPNQSSQADR SNEYNEGEIS KGAENAT
