CB078_HUMAN
ID CB078_HUMAN Reviewed; 922 AA.
AC A6NCI8;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 05-APR-2011, sequence version 3.
DT 03-AUG-2022, entry version 84.
DE RecName: Full=Uncharacterized protein C2orf78;
GN Name=C2orf78;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
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DR EMBL; AK125975; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AC092653; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS46338.1; -.
DR RefSeq; NP_001073943.1; NM_001080474.1.
DR RefSeq; XP_005264359.1; XM_005264302.3.
DR AlphaFoldDB; A6NCI8; -.
DR BioGRID; 132921; 4.
DR IntAct; A6NCI8; 3.
DR STRING; 9606.ENSP00000387124; -.
DR iPTMnet; A6NCI8; -.
DR PhosphoSitePlus; A6NCI8; -.
DR BioMuta; C2orf78; -.
DR PaxDb; A6NCI8; -.
DR PeptideAtlas; A6NCI8; -.
DR PRIDE; A6NCI8; -.
DR ProteomicsDB; 838; -.
DR DNASU; 388960; -.
DR Ensembl; ENST00000409561.1; ENSP00000387124.1; ENSG00000187833.7.
DR GeneID; 388960; -.
DR KEGG; hsa:388960; -.
DR MANE-Select; ENST00000409561.2; ENSP00000387124.1; NM_001080474.3; NP_001073943.1.
DR UCSC; uc002sjr.1; human.
DR CTD; 388960; -.
DR GeneCards; C2orf78; -.
DR HGNC; HGNC:34349; C2orf78.
DR HPA; ENSG00000187833; Tissue enriched (testis).
DR neXtProt; NX_A6NCI8; -.
DR OpenTargets; ENSG00000187833; -.
DR VEuPathDB; HostDB:ENSG00000187833; -.
DR eggNOG; ENOG502SEP6; Eukaryota.
DR GeneTree; ENSGT00390000014208; -.
DR HOGENOM; CLU_016596_0_0_1; -.
DR InParanoid; A6NCI8; -.
DR OMA; YRASAHQ; -.
DR OrthoDB; 669317at2759; -.
DR PhylomeDB; A6NCI8; -.
DR TreeFam; TF337929; -.
DR PathwayCommons; A6NCI8; -.
DR SignaLink; A6NCI8; -.
DR BioGRID-ORCS; 388960; 7 hits in 1051 CRISPR screens.
DR GenomeRNAi; 388960; -.
DR Pharos; A6NCI8; Tdark.
DR PRO; PR:A6NCI8; -.
DR Proteomes; UP000005640; Chromosome 2.
DR RNAct; A6NCI8; protein.
DR Bgee; ENSG00000187833; Expressed in left testis and 5 other tissues.
DR InterPro; IPR040292; C2orf78-like.
DR InterPro; IPR027898; DUF4629.
DR PANTHER; PTHR31466; PTHR31466; 1.
DR Pfam; PF15442; DUF4629; 1.
PE 2: Evidence at transcript level;
KW Coiled coil; Reference proteome.
FT CHAIN 1..922
FT /note="Uncharacterized protein C2orf78"
FT /id="PRO_0000319422"
FT REGION 459..522
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 539..627
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 649..668
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 692..835
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 856..879
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 872..899
FT /evidence="ECO:0000255"
FT COMPBIAS 477..491
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 493..510
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 565..616
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 754..835
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 922 AA; 100170 MW; 866A70E766774B03 CRC64;
MHWLASATQT SASIVSSSLL SAVDVSSSLT MSEYFQNTSL PGTANSRQFS LPVVSNAAFL
TGSISNFSRA SAPAISSAWL QPSASGTSFQ PLMGSAYLYQ HSSTTMLSGV TGQSHICTSA
ASYPGVFEWD STASTVKKSS SLRDFTVTVI DQNTAVSSMS MTAQYYKTSD TNTMVPLYPS
LSASLVQGTL TQIPNQQGHN LSLPCQIGSQ VYYYNQGTLG PQLSCLQSYG SVSYTGYRAS
AHQPEMVMVL KEVQPTNVLP PVSTSGMYYS VSSQPITETS VQVMETSLGM DTSLGLQSPS
QTFCLPQTPE FSKSFSSRNT QTLESNPSPE LGDISITPVQ SPTNLLTLSP APSQEKNENE
NLDEIKTNLS KPLDVHQILI GNQDPPLLPV EIPDIHPLLA CIDPLGQEEQ PGSENANLRN
KSLSLEDQGI FENGIESSSD LADITTWVED TYLPPIFSSL QDLDQPESPS AKKAKDTSAI
KVNQVQEKSC VIKGHSDQVR KNKHKASEPI QGAPKAKIQP KNPECLLERE VVVGSATVSN
SASVNKAKHS SNKPHKAASS RISKTKSHGQ EKTKGNRKNS SKKSEESKQS GKKVKVEEKQ
TIPNMKRKKN QPELSQKTLK KPRSSLGMHM LESVQVFHAL GKKIDMKTGF SSSRTLGSSS
NTQNRQPFPA LKPWLDIQHE GKGPEKIQVK AQKLDGSAEK ECTSPSHSEL PPPGKVKLIP
LPFLTLDQPQ ARHVSRRPNP LASRRPAVAY PARPDSTNSA QSNAVNPSRP APTNTSLTGP
ATPAQPISAK ATQPSSANPT QPTVPQSAAS RPSAYKTSSC SSLQREPVST AVTSLRSLPK
PQNQFLIQDF SLQPRPWRKP TVPEPVMSTP ITEEQRPERE AMKRKAQQER ENAAKYTSLG
KVQFFIERER DMEIAEYYGY TI
