YD541_YEAST
ID YD541_YEAST Reviewed; 344 AA.
AC Q03049; D6VTG0;
DT 17-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 27-JUL-2011, sequence version 2.
DT 03-AUG-2022, entry version 154.
DE RecName: Full=Putative uncharacterized oxidoreductase YDR541C;
DE EC=1.1.1.-;
GN OrderedLocusNames=YDR541C;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169867;
RA Jacq C., Alt-Moerbe J., Andre B., Arnold W., Bahr A., Ballesta J.P.G.,
RA Bargues M., Baron L., Becker A., Biteau N., Bloecker H., Blugeon C.,
RA Boskovic J., Brandt P., Brueckner M., Buitrago M.J., Coster F.,
RA Delaveau T., del Rey F., Dujon B., Eide L.G., Garcia-Cantalejo J.M.,
RA Goffeau A., Gomez-Peris A., Granotier C., Hanemann V., Hankeln T.,
RA Hoheisel J.D., Jaeger W., Jimenez A., Jonniaux J.-L., Kraemer C.,
RA Kuester H., Laamanen P., Legros Y., Louis E.J., Moeller-Rieker S.,
RA Monnet A., Moro M., Mueller-Auer S., Nussbaumer B., Paricio N., Paulin L.,
RA Perea J., Perez-Alonso M., Perez-Ortin J.E., Pohl T.M., Prydz H.,
RA Purnelle B., Rasmussen S.W., Remacha M.A., Revuelta J.L., Rieger M.,
RA Salom D., Saluz H.P., Saiz J.E., Saren A.-M., Schaefer M., Scharfe M.,
RA Schmidt E.R., Schneider C., Scholler P., Schwarz S., Soler-Mira A.,
RA Urrestarazu L.A., Verhasselt P., Vissers S., Voet M., Volckaert G.,
RA Wagner G., Wambutt R., Wedler E., Wedler H., Woelfl S., Harris D.E.,
RA Bowman S., Brown D., Churcher C.M., Connor R., Dedman K., Gentles S.,
RA Hamlin N., Hunt S., Jones L., McDonald S., Murphy L.D., Niblett D.,
RA Odell C., Oliver K., Rajandream M.A., Richards C., Shore L., Walsh S.V.,
RA Barrell B.G., Dietrich F.S., Mulligan J.T., Allen E., Araujo R., Aviles E.,
RA Berno A., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M.,
RA Hunicke-Smith S., Hyman R.W., Komp C., Lashkari D., Lew H., Lin D.,
RA Mosedale D., Nakahara K., Namath A., Oefner P., Oh C., Petel F.X.,
RA Roberts D., Schramm S., Schroeder M., Shogren T., Shroff N., Winant A.,
RA Yelton M.A., Botstein D., Davis R.W., Johnston M., Andrews S., Brinkman R.,
RA Cooper J., Ding H., Du Z., Favello A., Fulton L., Gattung S., Greco T.,
RA Hallsworth K., Hawkins J., Hillier L.W., Jier M., Johnson D., Johnston L.,
RA Kirsten J., Kucaba T., Langston Y., Latreille P., Le T., Mardis E.,
RA Menezes S., Miller N., Nhan M., Pauley A., Peluso D., Rifkin L., Riles L.,
RA Taich A., Trevaskis E., Vignati D., Wilcox L., Wohldman P., Vaudin M.,
RA Wilson R., Waterston R., Albermann K., Hani J., Heumann K., Kleine K.,
RA Mewes H.-W., Zollner A., Zaccaria P.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome IV.";
RL Nature 387:75-78(1997).
RN [2]
RP GENOME REANNOTATION, AND SEQUENCE REVISION TO 341.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=17322287; DOI=10.1101/gr.6037607;
RA Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F.,
RA Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J.,
RA Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J.,
RA Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D.,
RA LaBaer J.;
RT "Approaching a complete repository of sequence-verified protein-encoding
RT clones for Saccharomyces cerevisiae.";
RL Genome Res. 17:536-543(2007).
CC -!- SIMILARITY: Belongs to the NAD(P)-dependent epimerase/dehydratase
CC family. Dihydroflavonol-4-reductase subfamily. {ECO:0000305}.
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DR EMBL; U43834; AAB64983.1; -; Genomic_DNA.
DR EMBL; AY692675; AAT92694.1; -; Genomic_DNA.
DR EMBL; BK006938; DAA12370.2; -; Genomic_DNA.
DR PIR; S62020; S62020.
DR RefSeq; NP_010830.4; NM_001180849.4.
DR AlphaFoldDB; Q03049; -.
DR SMR; Q03049; -.
DR BioGRID; 32588; 83.
DR DIP; DIP-5276N; -.
DR IntAct; Q03049; 4.
DR MINT; Q03049; -.
DR STRING; 4932.YDR541C; -.
DR MaxQB; Q03049; -.
DR PaxDb; Q03049; -.
DR PRIDE; Q03049; -.
DR EnsemblFungi; YDR541C_mRNA; YDR541C; YDR541C.
DR GeneID; 852154; -.
DR KEGG; sce:YDR541C; -.
DR SGD; S000002949; YDR541C.
DR VEuPathDB; FungiDB:YDR541C; -.
DR eggNOG; KOG1502; Eukaryota.
DR GeneTree; ENSGT00940000176317; -.
DR HOGENOM; CLU_007383_9_2_1; -.
DR InParanoid; Q03049; -.
DR OMA; VPSRCKD; -.
DR BioCyc; YEAST:G3O-30049-MON; -.
DR PRO; PR:Q03049; -.
DR Proteomes; UP000002311; Chromosome IV.
DR RNAct; Q03049; protein.
DR GO; GO:0033721; F:aldehyde dehydrogenase (NADP+) activity; IDA:SGD.
DR GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IBA:GO_Central.
DR GO; GO:1901426; P:response to furfural; IMP:SGD.
DR InterPro; IPR001509; Epimerase_deHydtase.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR Pfam; PF01370; Epimerase; 1.
DR SUPFAM; SSF51735; SSF51735; 1.
PE 3: Inferred from homology;
KW Oxidoreductase; Reference proteome.
FT CHAIN 1..344
FT /note="Putative uncharacterized oxidoreductase YDR541C"
FT /id="PRO_0000253887"
FT BINDING 38
FT /ligand="NADP(+)"
FT /ligand_id="ChEBI:CHEBI:58349"
FT /evidence="ECO:0000250|UniProtKB:A0A059TC02"
FT BINDING 167
FT /ligand="NADP(+)"
FT /ligand_id="ChEBI:CHEBI:58349"
FT /evidence="ECO:0000250|UniProtKB:A0A059TC02"
FT CONFLICT 341
FT /note="Q -> E (in Ref. 1; AAB64983 and 3; AAT92694)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 344 AA; 38586 MW; B920E3CD32531254 CRC64;
MSNTVLVSGA SGFIALHILS QLLKQDYKVI GTVRSHEKEA KLLRQFQHNP NLTLEIVPDI
SHPNAFDKVL QKRGREIRYV LHTASPFHYD TTEYEKDLLI PALEGTKNIL NSIKKYAADT
VERVVVTSSC TAIITLAKMD DPSVVFTEES WNEATWESCQ IDGINAYFAS KKFAEKAAWE
FTKENEDHIK FKLTTVNPSL LFGPQLFDED VHGHLNTSCE MINGLIHTPV NASVPDFHSI
FIDVRDVALA HLYAFQKENT AGKRLVVTNG KFGNQDILDI LNEDFPQLRG LIPLGKPGTG
DQVIDRGSTT DNSATRKILG FEFRSLHESV HDTAAQILKK QNRL
