ID   CB081_HUMAN             Reviewed;         582 AA.
AC   A6NN90; A0A087WXZ4;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   28-MAR-2018, sequence version 3.
DT   03-AUG-2022, entry version 78.
DE   RecName: Full=Uncharacterized protein C2orf81 {ECO:0000305};
GN   Name=C2orf81 {ECO:0000312|HGNC:HGNC:34350};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15815621; DOI=10.1038/nature03466;
RA   Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA   Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA   Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA   Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA   Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA   Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA   Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA   Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA   Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA   McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA   Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA   Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA   Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA   Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA   Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA   Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA   Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA   Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA   Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA   Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA   Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA   Wilson R.K.;
RT   "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT   4.";
RL   Nature 434:724-731(2005).
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DR   EMBL; AC005041; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; A6NN90; -.
DR   IntAct; A6NN90; 1.
DR   STRING; 9606.ENSP00000290390; -.
DR   PhosphoSitePlus; A6NN90; -.
DR   BioMuta; C2orf81; -.
DR   MassIVE; A6NN90; -.
DR   PaxDb; A6NN90; -.
DR   PeptideAtlas; A6NN90; -.
DR   PRIDE; A6NN90; -.
DR   ProteomicsDB; 1589; -.
DR   Antibodypedia; 78613; 3 antibodies from 3 providers.
DR   Ensembl; ENST00000612891.4; ENSP00000481409.1; ENSG00000284308.2.
DR   GeneCards; C2orf81; -.
DR   HGNC; HGNC:34350; C2orf81.
DR   HPA; ENSG00000284308; Tissue enhanced (fallopian tube, pituitary gland, testis).
DR   neXtProt; NX_A6NN90; -.
DR   VEuPathDB; HostDB:ENSG00000284308; -.
DR   eggNOG; KOG1208; Eukaryota.
DR   GeneTree; ENSGT00390000014979; -.
DR   InParanoid; A6NN90; -.
DR   PhylomeDB; A6NN90; -.
DR   PathwayCommons; A6NN90; -.
DR   ChiTaRS; C2orf81; human.
DR   Pharos; A6NN90; Tdark.
DR   PRO; PR:A6NN90; -.
DR   Proteomes; UP000005640; Chromosome 2.
DR   RNAct; A6NN90; protein.
DR   Bgee; ENSG00000284308; Expressed in right uterine tube and 101 other tissues.
DR   ExpressionAtlas; A6NN90; baseline and differential.
DR   InterPro; IPR028042; DUF4639.
DR   PANTHER; PTHR34438; PTHR34438; 1.
DR   Pfam; PF15479; DUF4639; 1.
PE   3: Inferred from homology;
KW   Phosphoprotein; Reference proteome.
FT   CHAIN           1..582
FT                   /note="Uncharacterized protein C2orf81"
FT                   /id="PRO_0000328766"
FT   REGION          1..29
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          110..133
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          147..221
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          310..331
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          551..582
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..19
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        171..195
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         242
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q6AXP4"
SQ   SEQUENCE   582 AA;  63239 MW;  B08717B63C2384F2 CRC64;
     MAHEGSRQVR DRGVTRSKAE KVRPPTVPVP QVDIVPGRLS EAEWMALTAL EEGEDVVGDI
     LADLLARVMD SAFKVYLTQQ CIPFTISQAR EAMLQITEWR FLARDEGESA VAEDPTWGED
     EEPSACTTDS WAQGSVPVLH ASTSEGLENF QGEDPGGVDR IPLGRSWMGR GSQEQMESWE
     PSPQLRVTSA PPPTSELFQE AGPGGPVEEA DGQSRGLSSA GSLSASFQLS VEEAPADDAD
     PSLDPYLVAS PQASTGRGHP LGFHLSLEDL YCCMPQLDAA GDRLELRSEG VPCIASGVLV
     SYPSVGGATR PSASCQQQRA GHSDVRLSAH HHRMRRKAAV KRLDPARLPC HWVRPLAEVL
     VPDSQTRPLE AYRGRQRGEK TKARAEPQAL GPGTRVSPAA FFPLRPGIPF RDLDSGPALL
     FPTLNLGLSS PSLESKLPLP NSRIRFLTTH PVLPDVARSR SPKLWPSVRW PSGWEGKAEL
     LGELWAGRTR VPPQGLELAD REGQDPGRWP RTTPPVLEAT SQVMWKPVLL PEALKLAPGV
     SMWNRSTQVL LSSGVPEQED KEGSTFPPVE QHPIQTGAPK PR