CB081_MOUSE
ID CB081_MOUSE Reviewed; 598 AA.
AC Q9DAQ4; A0JNU0;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 27-JUL-2011, sequence version 3.
DT 03-AUG-2022, entry version 95.
DE RecName: Full=Uncharacterized protein C2orf81 homolog;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
RC STRAIN=C57BL/6J; TISSUE=Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q9DAQ4-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9DAQ4-2; Sequence=VSP_032776;
CC Name=3;
CC IsoId=Q9DAQ4-3; Sequence=VSP_032777;
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DR EMBL; AK005628; BAB24157.1; -; mRNA.
DR EMBL; AC104324; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC160400; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC126949; AAI26950.1; -; mRNA.
DR CCDS; CCDS51818.1; -. [Q9DAQ4-1]
DR RefSeq; NP_082224.1; NM_027948.1. [Q9DAQ4-1]
DR AlphaFoldDB; Q9DAQ4; -.
DR STRING; 10090.ENSMUSP00000032106; -.
DR iPTMnet; Q9DAQ4; -.
DR PhosphoSitePlus; Q9DAQ4; -.
DR PaxDb; Q9DAQ4; -.
DR PRIDE; Q9DAQ4; -.
DR Ensembl; ENSMUST00000032106; ENSMUSP00000032106; ENSMUSG00000030030. [Q9DAQ4-1]
DR GeneID; 71837; -.
DR KEGG; mmu:71837; -.
DR UCSC; uc009cmx.2; mouse. [Q9DAQ4-1]
DR MGI; MGI:1919087; 1700003E16Rik.
DR VEuPathDB; HostDB:ENSMUSG00000030030; -.
DR eggNOG; KOG1208; Eukaryota.
DR GeneTree; ENSGT00390000014979; -.
DR HOGENOM; CLU_032316_0_0_1; -.
DR InParanoid; Q9DAQ4; -.
DR OMA; WKPMLLP; -.
DR OrthoDB; 1472146at2759; -.
DR PhylomeDB; Q9DAQ4; -.
DR TreeFam; TF336850; -.
DR BioGRID-ORCS; 71837; 3 hits in 74 CRISPR screens.
DR PRO; PR:Q9DAQ4; -.
DR Proteomes; UP000000589; Chromosome 6.
DR RNAct; Q9DAQ4; protein.
DR Bgee; ENSMUSG00000030030; Expressed in spermatid and 58 other tissues.
DR ExpressionAtlas; Q9DAQ4; baseline and differential.
DR Genevisible; Q9DAQ4; MM.
DR InterPro; IPR028042; DUF4639.
DR PANTHER; PTHR34438; PTHR34438; 1.
DR Pfam; PF15479; DUF4639; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Phosphoprotein; Reference proteome.
FT CHAIN 1..598
FT /note="Uncharacterized protein C2orf81 homolog"
FT /id="PRO_0000328767"
FT REGION 1..32
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 151..190
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 222..241
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 366..396
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 551..571
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..19
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 165..183
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 368..390
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 238
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q6AXP4"
FT MOD_RES 242
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q6AXP4"
FT VAR_SEQ 1..217
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_032776"
FT VAR_SEQ 1..92
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_032777"
FT CONFLICT 365
FT /note="P -> R (in Ref. 3; AAI26950)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 598 AA; 65778 MW; 4C8BFAED17E94D5A CRC64;
MSHEGSRQAR DRGVTRSKAE KARPPTQPVP QVDIVPGRLN EAEWIAFMSL EEGEDVVGDI
LADLMTRVME CAFKVYLTQQ CVPFTISQAR EAMLQITEWR FLARDEGESA VAEDPTWGED
EEPLACTTDS WAQGSVPVLH TPAPVCVEEQ FHNEEPGNPD QFLLGSSWDK ESQKPTQPSE
PSAEPKVTPR PTATLEAFEE AEPGDALEVP HGQEGSHMLA VPSKESLRST AEGERVYSPQ
SSLKQPQVVR LQASEKESSF GSHLSLEDLY LCMPQPDAAG DRLSLQSKGQ LHSSPIGSES
HLGALTPAEP SAFQEPEVLG ERPKHKTTTL RMDSSRLPRH WVRPVAEVLI PDLEVHPLEI
YRGRPRRSQA GTATSACESQ ALSSRAPSKP HVSSPRFPLQ RCATFRALGP DPSLNLAQTS
PSFGSNVPFL SPGFRFLPRN PIPPDVASTP TPKLWPLAKW PSGWEREAEQ LGELWAGRTR
VPPQGQEPVE VTPLEEDSGW PLAAPQVLEA TSQVLWKPMV ISETMKLVPG VSMWNRGTQE
LLNPAVIRKE AEEGTPQAPE QQPIQTGVSK PQVIMKQIRN ETPKAWLLPT KPVPHSGS
