YDCU_ECOLI
ID YDCU_ECOLI Reviewed; 313 AA.
AC P77156;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1997, sequence version 1.
DT 03-AUG-2022, entry version 142.
DE RecName: Full=Inner membrane ABC transporter permease protein YdcU {ECO:0000305};
GN Name=ydcU; OrderedLocusNames=b1442, JW1437;
OS Escherichia coli (strain K12).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83333;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=9097039; DOI=10.1093/dnares/3.6.363;
RA Aiba H., Baba T., Fujita K., Hayashi K., Inada T., Isono K., Itoh T.,
RA Kasai H., Kashimoto K., Kimura S., Kitakawa M., Kitagawa M., Makino K.,
RA Miki T., Mizobuchi K., Mori H., Mori T., Motomura K., Nakade S.,
RA Nakamura Y., Nashimoto H., Nishio Y., Oshima T., Saito N., Sampei G.,
RA Seki Y., Sivasundaram S., Tagami H., Takeda J., Takemoto K., Takeuchi Y.,
RA Wada C., Yamamoto Y., Horiuchi T.;
RT "A 570-kb DNA sequence of the Escherichia coli K-12 genome corresponding to
RT the 28.0-40.1 min region on the linkage map.";
RL DNA Res. 3:363-377(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA Shao Y.;
RT "The complete genome sequence of Escherichia coli K-12.";
RL Science 277:1453-1462(1997).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=16738553; DOI=10.1038/msb4100049;
RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT and W3110.";
RL Mol. Syst. Biol. 2:E1-E5(2006).
RN [4]
RP TOPOLOGY [LARGE SCALE ANALYSIS], AND SUBCELLULAR LOCATION.
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=15919996; DOI=10.1126/science.1109730;
RA Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.;
RT "Global topology analysis of the Escherichia coli inner membrane
RT proteome.";
RL Science 308:1321-1323(2005).
RN [5]
RP DISRUPTION PHENOTYPE.
RX PubMed=26826386; DOI=10.1016/j.bbrc.2016.01.137;
RA Sun D.;
RT "Two different routes for double-stranded DNA transfer in natural and
RT artificial transformation of Escherichia coli.";
RL Biochem. Biophys. Res. Commun. 471:213-218(2016).
CC -!- FUNCTION: Probably part of the ABC transporter complex YdcSTUV.
CC Probably responsible for the translocation of the substrate across the
CC membrane. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- DISRUPTION PHENOTYPE: Inactivation of the gene does not significantly
CC affect natural transformation. {ECO:0000269|PubMed:26826386}.
CC -!- SIMILARITY: Belongs to the binding-protein-dependent transport system
CC permease family. CysTW subfamily. {ECO:0000305}.
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DR EMBL; U00096; AAC74524.1; -; Genomic_DNA.
DR EMBL; AP009048; BAA15071.1; -; Genomic_DNA.
DR PIR; E64896; E64896.
DR RefSeq; NP_415959.1; NC_000913.3.
DR RefSeq; WP_001251304.1; NZ_SSZK01000021.1.
DR AlphaFoldDB; P77156; -.
DR BioGRID; 4260191; 93.
DR ComplexPortal; CPX-4446; YdcSTUV ABC transporter complex.
DR STRING; 511145.b1442; -.
DR TCDB; 3.A.1.11.9; the atp-binding cassette (abc) superfamily.
DR PaxDb; P77156; -.
DR PRIDE; P77156; -.
DR EnsemblBacteria; AAC74524; AAC74524; b1442.
DR EnsemblBacteria; BAA15071; BAA15071; BAA15071.
DR GeneID; 945976; -.
DR KEGG; ecj:JW1437; -.
DR KEGG; eco:b1442; -.
DR PATRIC; fig|1411691.4.peg.826; -.
DR EchoBASE; EB3527; -.
DR eggNOG; COG1176; Bacteria.
DR HOGENOM; CLU_016047_18_1_6; -.
DR InParanoid; P77156; -.
DR OMA; YYMARYT; -.
DR PhylomeDB; P77156; -.
DR BioCyc; EcoCyc:YDCU-MON; -.
DR BioCyc; MetaCyc:YDCU-MON; -.
DR PRO; PR:P77156; -.
DR Proteomes; UP000000318; Chromosome.
DR Proteomes; UP000000625; Chromosome.
DR GO; GO:0055052; C:ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing; IC:ComplexPortal.
DR GO; GO:0005887; C:integral component of plasma membrane; ISM:EcoCyc.
DR GO; GO:0016020; C:membrane; IC:ComplexPortal.
DR GO; GO:0055085; P:transmembrane transport; IC:ComplexPortal.
DR CDD; cd06261; TM_PBP2; 1.
DR Gene3D; 1.10.3720.10; -; 1.
DR InterPro; IPR000515; MetI-like.
DR InterPro; IPR035906; MetI-like_sf.
DR Pfam; PF00528; BPD_transp_1; 1.
DR SUPFAM; SSF161098; SSF161098; 1.
DR PROSITE; PS50928; ABC_TM1; 1.
PE 1: Evidence at protein level;
KW Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..313
FT /note="Inner membrane ABC transporter permease protein
FT YdcU"
FT /id="PRO_0000060242"
FT TOPO_DOM 1..25
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 26..46
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 47..92
FT /note="Periplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 93..113
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 114..122
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 123..143
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 144..154
FT /note="Periplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 155..175
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 176..187
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 188..208
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 209..230
FT /note="Periplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 231..251
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 252
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 253..273
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 274..283
FT /note="Periplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 284..304
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 305..313
FT /note="Cytoplasmic"
FT /evidence="ECO:0000269|PubMed:15919996"
FT DOMAIN 87..302
FT /note="ABC transmembrane type-1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
SQ SEQUENCE 313 AA; 34360 MW; 1B7353627183720F CRC64;
MAMNVLQSPS RPGLGKVSGF FWHNPGLGLF LLLLGPLMWF GIVYFGSLLT LLWQGFYTFD
DFTMSVTPEL TLANIRALFN PANYDIILRT LTMAVAVTIA SAILAFPMAW YMARYTSGKM
KAFFYIAVML PMWASYIVKA YAWTLLLAKD GVAQWFLQHL GLEPLLTAFL TLPAVGGNTL
STSGLGRFLV FLYIWLPFMI LPVQAALERL PPSLLQASAD LGARPRQTFR YVVLPLAIPG
IAAGSIFTFS LTLGDFIVPQ LVGPPGYFIG NMVYSQQGAI GNMPMAAAFT LVPIILIALY
LAFVKRLGAF DAL
