YDCV_ECOLI
ID YDCV_ECOLI Reviewed; 264 AA.
AC P0AFR9; P77505;
DT 20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 20-DEC-2005, sequence version 1.
DT 03-AUG-2022, entry version 108.
DE RecName: Full=Inner membrane ABC transporter permease protein YdcV {ECO:0000305};
GN Name=ydcV; OrderedLocusNames=b1443, JW1438;
OS Escherichia coli (strain K12).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83333;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=9097039; DOI=10.1093/dnares/3.6.363;
RA Aiba H., Baba T., Fujita K., Hayashi K., Inada T., Isono K., Itoh T.,
RA Kasai H., Kashimoto K., Kimura S., Kitakawa M., Kitagawa M., Makino K.,
RA Miki T., Mizobuchi K., Mori H., Mori T., Motomura K., Nakade S.,
RA Nakamura Y., Nashimoto H., Nishio Y., Oshima T., Saito N., Sampei G.,
RA Seki Y., Sivasundaram S., Tagami H., Takeda J., Takemoto K., Takeuchi Y.,
RA Wada C., Yamamoto Y., Horiuchi T.;
RT "A 570-kb DNA sequence of the Escherichia coli K-12 genome corresponding to
RT the 28.0-40.1 min region on the linkage map.";
RL DNA Res. 3:363-377(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA Shao Y.;
RT "The complete genome sequence of Escherichia coli K-12.";
RL Science 277:1453-1462(1997).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=16738553; DOI=10.1038/msb4100049;
RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT and W3110.";
RL Mol. Syst. Biol. 2:E1-E5(2006).
RN [4]
RP TOPOLOGY [LARGE SCALE ANALYSIS], AND SUBCELLULAR LOCATION.
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=15919996; DOI=10.1126/science.1109730;
RA Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.;
RT "Global topology analysis of the Escherichia coli inner membrane
RT proteome.";
RL Science 308:1321-1323(2005).
RN [5]
RP FUNCTION IN TRANSFORMATION, AND DISRUPTION PHENOTYPE.
RX PubMed=26826386; DOI=10.1016/j.bbrc.2016.01.137;
RA Sun D.;
RT "Two different routes for double-stranded DNA transfer in natural and
RT artificial transformation of Escherichia coli.";
RL Biochem. Biophys. Res. Commun. 471:213-218(2016).
CC -!- FUNCTION: Involved in natural transformation (PubMed:26826386).
CC Probably part of the ABC transporter complex YdcSTUV. Probably
CC responsible for the translocation of the substrate across the membrane.
CC During natural transformation, may serve as the channel for dsDNA
CC uptake (Probable). {ECO:0000269|PubMed:26826386,
CC ECO:0000305|PubMed:26826386}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- DISRUPTION PHENOTYPE: Natural transformation rate of the mutant is
CC reduced by 3.3-9.5 folds. Mutation does not affect chemical
CC transformation. {ECO:0000269|PubMed:26826386}.
CC -!- SIMILARITY: Belongs to the binding-protein-dependent transport system
CC permease family. CysTW subfamily. {ECO:0000305}.
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DR EMBL; U00096; AAC74525.1; -; Genomic_DNA.
DR EMBL; AP009048; BAA15072.1; -; Genomic_DNA.
DR PIR; F64896; F64896.
DR RefSeq; NP_415960.1; NC_000913.3.
DR RefSeq; WP_000555458.1; NZ_SSZK01000021.1.
DR AlphaFoldDB; P0AFR9; -.
DR SMR; P0AFR9; -.
DR BioGRID; 4260190; 44.
DR ComplexPortal; CPX-4446; YdcSTUV ABC transporter complex.
DR STRING; 511145.b1443; -.
DR TCDB; 3.A.1.11.9; the atp-binding cassette (abc) superfamily.
DR PaxDb; P0AFR9; -.
DR PRIDE; P0AFR9; -.
DR EnsemblBacteria; AAC74525; AAC74525; b1443.
DR EnsemblBacteria; BAA15072; BAA15072; BAA15072.
DR GeneID; 945903; -.
DR KEGG; ecj:JW1438; -.
DR KEGG; eco:b1443; -.
DR PATRIC; fig|1411691.4.peg.825; -.
DR EchoBASE; EB3528; -.
DR eggNOG; COG1177; Bacteria.
DR HOGENOM; CLU_016047_3_0_6; -.
DR InParanoid; P0AFR9; -.
DR OMA; GFQTFRH; -.
DR PhylomeDB; P0AFR9; -.
DR BioCyc; EcoCyc:YDCV-MON; -.
DR BioCyc; MetaCyc:YDCV-MON; -.
DR PRO; PR:P0AFR9; -.
DR Proteomes; UP000000318; Chromosome.
DR Proteomes; UP000000625; Chromosome.
DR GO; GO:0055052; C:ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing; IC:ComplexPortal.
DR GO; GO:0016020; C:membrane; IC:ComplexPortal.
DR GO; GO:0005886; C:plasma membrane; IDA:EcoCyc.
DR GO; GO:0009290; P:DNA import into cell involved in transformation; IMP:EcoCyc.
DR GO; GO:0055085; P:transmembrane transport; IC:ComplexPortal.
DR CDD; cd06261; TM_PBP2; 1.
DR Gene3D; 1.10.3720.10; -; 1.
DR InterPro; IPR000515; MetI-like.
DR InterPro; IPR035906; MetI-like_sf.
DR Pfam; PF00528; BPD_transp_1; 1.
DR SUPFAM; SSF161098; SSF161098; 1.
DR PROSITE; PS50928; ABC_TM1; 1.
PE 1: Evidence at protein level;
KW Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..264
FT /note="Inner membrane ABC transporter permease protein
FT YdcV"
FT /id="PRO_0000060243"
FT TOPO_DOM 1..12
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 13..33
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 34..70
FT /note="Periplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 71..91
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 92..100
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 101..121
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 122..128
FT /note="Periplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 129..149
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 150..189
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 190..210
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 211..236
FT /note="Periplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 237..257
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 258..264
FT /note="Cytoplasmic"
FT /evidence="ECO:0000269|PubMed:15919996"
FT DOMAIN 65..252
FT /note="ABC transmembrane type-1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
SQ SEQUENCE 264 AA; 28722 MW; 611F6181E57DB826 CRC64;
MHSERAPFFL KLAAWGGVVF LHFPILIIAA YAFNTEDAAF SFPPQGLTLR WFSVAAQRSD
ILDAVTLSLK VAALATLIAL VLGTLAAAAL WRRDFFGKNA ISLLLLLPIA LPGIVTGLAL
LTAFKTINLE PGFFTIVVGH ATFCVVVVFN NVIARFRRTS WSLVEASMDL GANGWQTFRY
VVLPNLSSAL LAGGMLAFAL SFDEIIVTTF TAGHERTLPL WLLNQLGRPR DVPVTNVVAL
LVMLVTTLPI LGAWWLTREG DNGQ
