YDDG_SALT1
ID YDDG_SALT1 Reviewed; 293 AA.
AC D0ZXP9;
DT 22-FEB-2012, integrated into UniProtKB/Swiss-Prot.
DT 19-JAN-2010, sequence version 1.
DT 03-AUG-2022, entry version 45.
DE RecName: Full=Aromatic amino acid exporter YddG {ECO:0000250|UniProtKB:P46136};
DE AltName: Full=Methyl viologen resistance protein YddG;
GN Name=yddG; OrderedLocusNames=STM14_1896;
OS Salmonella typhimurium (strain 14028s / SGSC 2262).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Salmonella.
OX NCBI_TaxID=588858;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=14028s / SGSC 2262;
RX PubMed=19897643; DOI=10.1128/jb.01233-09;
RA Jarvik T., Smillie C., Groisman E.A., Ochman H.;
RT "Short-term signatures of evolutionary change in the Salmonella enterica
RT serovar typhimurium 14028 genome.";
RL J. Bacteriol. 192:560-567(2010).
RN [2]
RP FUNCTION IN METHYL VIOLOGEN RESISTANCE, AND DISRUPTION PHENOTYPE.
RC STRAIN=14028s / SGSC 2262;
RX PubMed=12410826; DOI=10.1046/j.1365-2958.2002.03204.x;
RA Santiviago C.A., Fuentes J.A., Bueno S.M., Trombert A.N., Hildago A.A.,
RA Socias L.T., Youderian P., Mora G.C.;
RT "The Salmonella enterica sv. Typhimurium smvA, yddG and ompD (porin) genes
RT are required for the efficient efflux of methyl viologen.";
RL Mol. Microbiol. 46:687-698(2002).
CC -!- FUNCTION: Amino acid transporter with broad substrate specificity (By
CC similarity). Required for resistance to methyl viologen
CC (PubMed:12410826). May function with OmpD porin (PubMed:12410826).
CC {ECO:0000250|UniProtKB:P46136, ECO:0000269|PubMed:12410826}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000250|UniProtKB:P46136}; Multi-pass membrane protein
CC {ECO:0000250|UniProtKB:P46136}.
CC -!- DISRUPTION PHENOTYPE: Mutants show increased sensitivity to methyl
CC viologen. {ECO:0000269|PubMed:12410826}.
CC -!- SIMILARITY: Belongs to the drug/metabolite transporter (DMT)
CC superfamily. Aromatic amino acid/paraquat exporter (ArAA/P-E) (TC
CC 2.A.7.17) family. {ECO:0000305}.
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DR EMBL; CP001363; ACY88367.1; -; Genomic_DNA.
DR RefSeq; WP_000203799.1; NZ_CP043402.1.
DR AlphaFoldDB; D0ZXP9; -.
DR SMR; D0ZXP9; -.
DR EnsemblBacteria; ACY88367; ACY88367; STM14_1896.
DR KEGG; seo:STM14_1896; -.
DR PATRIC; fig|588858.6.peg.1808; -.
DR HOGENOM; CLU_058959_1_1_6; -.
DR OMA; VALWFHY; -.
DR BioCyc; SENT588858:STM14_RS08730-MON; -.
DR Proteomes; UP000002695; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0006865; P:amino acid transport; IEA:UniProtKB-KW.
DR InterPro; IPR000620; EamA_dom.
DR Pfam; PF00892; EamA; 2.
PE 1: Evidence at protein level;
KW Amino-acid transport; Cell inner membrane; Cell membrane; Membrane; Repeat;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..293
FT /note="Aromatic amino acid exporter YddG"
FT /id="PRO_0000415645"
FT TOPO_DOM 1..6
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250|UniProtKB:P46136"
FT TRANSMEM 7..27
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 28..33
FT /note="Periplasmic"
FT /evidence="ECO:0000250|UniProtKB:P46136"
FT TRANSMEM 34..54
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 55..63
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250|UniProtKB:P46136"
FT TRANSMEM 64..84
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 85..92
FT /note="Periplasmic"
FT /evidence="ECO:0000250|UniProtKB:P46136"
FT TRANSMEM 93..113
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 114..119
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250|UniProtKB:P46136"
FT TRANSMEM 120..140
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 141..147
FT /note="Periplasmic"
FT /evidence="ECO:0000250|UniProtKB:P46136"
FT TRANSMEM 148..168
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 169..182
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250|UniProtKB:P46136"
FT TRANSMEM 183..203
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 204..207
FT /note="Periplasmic"
FT /evidence="ECO:0000250|UniProtKB:P46136"
FT TRANSMEM 208..228
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 229..243
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250|UniProtKB:P46136"
FT TRANSMEM 244..264
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 265..267
FT /note="Periplasmic"
FT /evidence="ECO:0000250|UniProtKB:P46136"
FT TRANSMEM 268..288
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 289..293
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250|UniProtKB:P46136"
FT DOMAIN 15..137
FT /note="EamA 1"
FT /evidence="ECO:0000255"
FT DOMAIN 167..285
FT /note="EamA 2"
FT /evidence="ECO:0000255"
SQ SEQUENCE 293 AA; 31427 MW; 9A8623B895B14225 CRC64;
MTSQKATLIG LVAIVLWSTM VGLIRGVSEG LGPVGGAAMI YSLSGLLLIF TVGLPDIRRF
PGRYLIAGSV LFVSYEICLA LSLGYAATRH QAIEVGMVNY LWPSLTILFA ILFNGQKTNW
LIVPGLLIAL TGVCWVLGGE NGLNPGEIIS NVATSPLSYL LAFLGAFIWA TYCTVTNKYA
RGFNGITVFV LLTAVALWLH YFLTPQPAMI FSLPVIAKLF TAALTLGFAY AAWNVGILHG
NVTIMAVGSY FTPVMSSALA ALLLSSPLSF SFWQGAVMVC VGSLLCWLAT RRR
