YDDH_BACSU
ID YDDH_BACSU Reviewed; 329 AA.
AC P96645;
DT 16-MAY-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1997, sequence version 1.
DT 03-AUG-2022, entry version 106.
DE RecName: Full=Probable endopeptidase YddH;
DE EC=3.4.-.-;
DE Flags: Precursor;
GN Name=yddH; OrderedLocusNames=BSU04970;
OS Bacillus subtilis (strain 168).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX NCBI_TaxID=224308;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=168;
RA Kasahara Y., Nakai S., Lee S., Sadaie Y., Ogasawara N.;
RT "A 148 kbp sequence of the region between 35 and 47 degree of the Bacillus
RT subtilis genome.";
RL Submitted (MAR-1997) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=168;
RX PubMed=9384377; DOI=10.1038/36786;
RA Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA Yoshikawa H., Danchin A.;
RT "The complete genome sequence of the Gram-positive bacterium Bacillus
RT subtilis.";
RL Nature 390:249-256(1997).
CC -!- SIMILARITY: Belongs to the peptidase C40 family. {ECO:0000255|PROSITE-
CC ProRule:PRU01284, ECO:0000305}.
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DR EMBL; AB001488; BAA19334.1; -; Genomic_DNA.
DR EMBL; AL009126; CAB12304.1; -; Genomic_DNA.
DR PIR; A69776; A69776.
DR RefSeq; NP_388378.1; NC_000964.3.
DR RefSeq; WP_009966633.1; NZ_JNCM01000031.1.
DR AlphaFoldDB; P96645; -.
DR SMR; P96645; -.
DR STRING; 224308.BSU04970; -.
DR CAZy; GH23; Glycoside Hydrolase Family 23.
DR MEROPS; C40.007; -.
DR PaxDb; P96645; -.
DR PRIDE; P96645; -.
DR DNASU; 938136; -.
DR EnsemblBacteria; CAB12304; CAB12304; BSU_04970.
DR GeneID; 938136; -.
DR KEGG; bsu:BSU04970; -.
DR PATRIC; fig|224308.179.peg.528; -.
DR eggNOG; COG0741; Bacteria.
DR eggNOG; COG0791; Bacteria.
DR OMA; EAVANNW; -.
DR PhylomeDB; P96645; -.
DR BioCyc; BSUB:BSU04970-MON; -.
DR Proteomes; UP000001570; Chromosome.
DR GO; GO:0008234; F:cysteine-type peptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0004175; F:endopeptidase activity; IDA:CACAO.
DR GO; GO:0003796; F:lysozyme activity; IDA:CACAO.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR InterPro; IPR023346; Lysozyme-like_dom_sf.
DR InterPro; IPR000064; NLP_P60_dom.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR Pfam; PF00877; NLPC_P60; 1.
DR SUPFAM; SSF53955; SSF53955; 1.
DR SUPFAM; SSF54001; SSF54001; 1.
DR PROSITE; PS51935; NLPC_P60; 1.
PE 3: Inferred from homology;
KW Hydrolase; Protease; Reference proteome; Signal; Thiol protease.
FT SIGNAL 1..29
FT /evidence="ECO:0000255"
FT CHAIN 30..329
FT /note="Probable endopeptidase YddH"
FT /id="PRO_0000019764"
FT DOMAIN 206..329
FT /note="NlpC/P60"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01284"
FT ACT_SITE 237
FT /note="Nucleophile"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01284"
FT ACT_SITE 290
FT /note="Proton acceptor"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01284"
FT ACT_SITE 302
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01284"
SQ SEQUENCE 329 AA; 36546 MW; B1ADD487E5F5C38E CRC64;
MISKKVVLPL VFSAPFIFFF VLCIVVVMTI SRENQVGDDF IGGGDGEYET VGIAPEVERF
RAVFEKYARQ EGVFDQVNII MALTMQESGG RSLDIMQSSE SIGLPPNSIT DPERSIEVGI
KHFKKVFKQA GGDVRLTLQA YNFGSGFIDY VKKNGGKYTK KLALDFSRLQ AFKMGWKSYG
DPSYVDHVMR YVKGSDKNVK PVKGSMDFYE TVMKEALKYE GQPYAWGGSN PETGFDCSGL
VQWSFAKAGI TLPRTAQEQH GATKKISEKE ATAGDLVFFG GTYEGKAITH VGIYVGNGRM
FNSNDSGIQY SDLKSGYWRD HLVSFGRIK
