ID   YDDM_ECOL6              Reviewed;          94 AA.
AC   P67700; P76125;
DT   11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 97.
DE   RecName: Full=Uncharacterized HTH-type transcriptional regulator YddM;
GN   Name=yddM; OrderedLocusNames=c1909;
OS   Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=199310;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CFT073 / ATCC 700928 / UPEC;
RX   PubMed=12471157; DOI=10.1073/pnas.252529799;
RA   Welch R.A., Burland V., Plunkett G. III, Redford P., Roesch P., Rasko D.,
RA   Buckles E.L., Liou S.-R., Boutin A., Hackett J., Stroud D., Mayhew G.F.,
RA   Rose D.J., Zhou S., Schwartz D.C., Perna N.T., Mobley H.L.T.,
RA   Donnenberg M.S., Blattner F.R.;
RT   "Extensive mosaic structure revealed by the complete genome sequence of
RT   uropathogenic Escherichia coli.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:17020-17024(2002).
RN   [2]
RP   X-RAY CRYSTALLOGRAPHY (1.63 ANGSTROMS).
RX   PubMed=20696400; DOI=10.1016/j.str.2010.04.018;
RA   Arbing M.A., Handelman S.K., Kuzin A.P., Verdon G., Wang C., Su M.,
RA   Rothenbacher F.P., Abashidze M., Liu M., Hurley J.M., Xiao R., Acton T.,
RA   Inouye M., Montelione G.T., Woychik N.A., Hunt J.F.;
RT   "Crystal structures of Phd-Doc, HigA, and YeeU establish multiple
RT   evolutionary links between microbial growth-regulating toxin-antitoxin
RT   systems.";
RL   Structure 18:996-1010(2010).
CC   -!- SIMILARITY: Belongs to the VapA/VapI family. {ECO:0000305}.
CC   -!- CAUTION: The crystal structure has erroneously been identified as HigA,
CC       the sequence submitted is in fact that of YddM.
CC       {ECO:0000305|PubMed:20696400}.
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DR   EMBL; AE014075; AAN80368.1; -; Genomic_DNA.
DR   RefSeq; WP_000781370.1; NC_004431.1.
DR   PDB; 2ICP; X-ray; 1.88 A; A=1-94.
DR   PDB; 2ICT; X-ray; 1.63 A; A=1-94.
DR   PDBsum; 2ICP; -.
DR   PDBsum; 2ICT; -.
DR   AlphaFoldDB; P67700; -.
DR   SMR; P67700; -.
DR   STRING; 199310.c1909; -.
DR   EnsemblBacteria; AAN80368; AAN80368; c1909.
DR   GeneID; 66674671; -.
DR   KEGG; ecc:c1909; -.
DR   eggNOG; COG3093; Bacteria.
DR   HOGENOM; CLU_140230_2_1_6; -.
DR   OMA; WMNLQTS; -.
DR   BioCyc; ECOL199310:C1909-MON; -.
DR   EvolutionaryTrace; P67700; -.
DR   Proteomes; UP000001410; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   CDD; cd00093; HTH_XRE; 1.
DR   Gene3D; 1.10.260.40; -; 1.
DR   InterPro; IPR001387; Cro/C1-type_HTH.
DR   InterPro; IPR010982; Lambda_DNA-bd_dom_sf.
DR   InterPro; IPR013430; Toxin_antidote_HigA.
DR   PANTHER; PTHR36924; PTHR36924; 1.
DR   Pfam; PF01381; HTH_3; 1.
DR   SMART; SM00530; HTH_XRE; 1.
DR   SUPFAM; SSF47413; SSF47413; 1.
DR   TIGRFAMs; TIGR02607; antidote_HigA; 1.
DR   PROSITE; PS50943; HTH_CROC1; 1.
PE   1: Evidence at protein level;
KW   3D-structure; DNA-binding; Transcription; Transcription regulation.
FT   CHAIN           1..94
FT                   /note="Uncharacterized HTH-type transcriptional regulator
FT                   YddM"
FT                   /id="PRO_0000149760"
FT   DOMAIN          13..67
FT                   /note="HTH cro/C1-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00257"
FT   DNA_BIND        24..43
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00257"
FT   HELIX           9..20
FT                   /evidence="ECO:0007829|PDB:2ICT"
FT   HELIX           24..31
FT                   /evidence="ECO:0007829|PDB:2ICT"
FT   HELIX           35..42
FT                   /evidence="ECO:0007829|PDB:2ICT"
FT   HELIX           50..59
FT                   /evidence="ECO:0007829|PDB:2ICT"
FT   HELIX           64..80
FT                   /evidence="ECO:0007829|PDB:2ICT"
FT   HELIX           85..87
FT                   /evidence="ECO:0007829|PDB:2ICP"
SQ   SEQUENCE   94 AA;  10401 MW;  E330280EDA2AEC1B CRC64;
     MKMANHPRPG DIIQESLDEL NVSLREFARA MEIAPSTASR LLTGKAALTP EMAIKLSVVI
     GSSPQMWLNL QNAWSLAEAE KTVDVSRLRR LVTQ