YDEA_BACSU
ID YDEA_BACSU Reviewed; 197 AA.
AC P96658; Q797I9;
DT 03-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1997, sequence version 1.
DT 03-AUG-2022, entry version 99.
DE RecName: Full=Uncharacterized protease YdeA;
DE EC=3.2.-.-;
GN Name=ydeA; OrderedLocusNames=BSU05110;
OS Bacillus subtilis (strain 168).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX NCBI_TaxID=224308;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=168;
RA Kasahara Y., Nakai S., Lee S., Sadaie Y., Ogasawara N.;
RT "A 148 kbp sequence of the region between 35 and 47 degree of the Bacillus
RT subtilis genome.";
RL Submitted (MAR-1997) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=168;
RX PubMed=9384377; DOI=10.1038/36786;
RA Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA Yoshikawa H., Danchin A.;
RT "The complete genome sequence of the Gram-positive bacterium Bacillus
RT subtilis.";
RL Nature 390:249-256(1997).
RN [3]
RP X-RAY CRYSTALLOGRAPHY (2.06 ANGSTROMS) OF 2-196.
RG New York structural genomics research consortium (NYSGRC);
RT "Crystal structure of a protein of unknown function from Bacillus
RT subtilis.";
RL Submitted (FEB-2009) to the PDB data bank.
CC -!- SIMILARITY: Belongs to the peptidase C56 family. {ECO:0000305}.
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DR EMBL; AB001488; BAA19347.1; -; Genomic_DNA.
DR EMBL; AL009126; CAB12318.1; -; Genomic_DNA.
DR PIR; C69777; C69777.
DR RefSeq; NP_388392.1; NC_000964.3.
DR RefSeq; WP_003234249.1; NZ_JNCM01000031.1.
DR PDB; 3F5D; X-ray; 2.06 A; A=2-196.
DR PDBsum; 3F5D; -.
DR AlphaFoldDB; P96658; -.
DR SMR; P96658; -.
DR STRING; 224308.BSU05110; -.
DR PaxDb; P96658; -.
DR PRIDE; P96658; -.
DR DNASU; 939914; -.
DR EnsemblBacteria; CAB12318; CAB12318; BSU_05110.
DR GeneID; 939914; -.
DR KEGG; bsu:BSU05110; -.
DR PATRIC; fig|224308.179.peg.545; -.
DR eggNOG; COG0693; Bacteria.
DR InParanoid; P96658; -.
DR OMA; DGFADWE; -.
DR PhylomeDB; P96658; -.
DR BioCyc; BSUB:BSU05110-MON; -.
DR EvolutionaryTrace; P96658; -.
DR Proteomes; UP000001570; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0019172; F:glyoxalase III activity; IBA:GO_Central.
DR GO; GO:0008233; F:peptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0019243; P:methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione; IBA:GO_Central.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.880; -; 1.
DR InterPro; IPR029062; Class_I_gatase-like.
DR InterPro; IPR002818; DJ-1/PfpI.
DR Pfam; PF01965; DJ-1_PfpI; 1.
DR SUPFAM; SSF52317; SSF52317; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Hydrolase; Protease; Reference proteome.
FT CHAIN 1..197
FT /note="Uncharacterized protease YdeA"
FT /id="PRO_0000388349"
FT DOMAIN ?29..?166
FT /note="PfpI endopeptidase"
FT ACT_SITE 98
FT /note="Nucleophile"
FT /evidence="ECO:0000250"
FT STRAND 2..7
FT /evidence="ECO:0007829|PDB:3F5D"
FT STRAND 10..12
FT /evidence="ECO:0007829|PDB:3F5D"
FT HELIX 18..25
FT /evidence="ECO:0007829|PDB:3F5D"
FT STRAND 30..43
FT /evidence="ECO:0007829|PDB:3F5D"
FT STRAND 48..50
FT /evidence="ECO:0007829|PDB:3F5D"
FT STRAND 52..54
FT /evidence="ECO:0007829|PDB:3F5D"
FT STRAND 63..67
FT /evidence="ECO:0007829|PDB:3F5D"
FT HELIX 78..89
FT /evidence="ECO:0007829|PDB:3F5D"
FT STRAND 94..97
FT /evidence="ECO:0007829|PDB:3F5D"
FT HELIX 99..106
FT /evidence="ECO:0007829|PDB:3F5D"
FT TURN 107..112
FT /evidence="ECO:0007829|PDB:3F5D"
FT HELIX 120..123
FT /evidence="ECO:0007829|PDB:3F5D"
FT STRAND 138..143
FT /evidence="ECO:0007829|PDB:3F5D"
FT STRAND 146..149
FT /evidence="ECO:0007829|PDB:3F5D"
FT HELIX 154..164
FT /evidence="ECO:0007829|PDB:3F5D"
FT HELIX 170..182
FT /evidence="ECO:0007829|PDB:3F5D"
FT HELIX 184..191
FT /evidence="ECO:0007829|PDB:3F5D"
SQ SEQUENCE 197 AA; 22454 MW; 952181570C6209DA CRC64;
MKKALFLILD QYADWEGVYL ASALNQREDW SVHTVSLDPI VSSIGGFKTS VDYIIGLEPA
NFNLLVMIGG DSWSNDNKKL LHFVKTAFQK NIPIAAICGA VDFLAKNGLL NNHSHTGNFV
YLWKDYKQYK PISSFVEKQA VRDKNLVTAN GTAPIEFTNL ILEMIDFDTP ENIEKMMYMN
RYGFYHFCDK YGNPFVD
