YDEE_ECOLI
ID YDEE_ECOLI Reviewed; 395 AA.
AC P31126; P31127; P76151;
DT 01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1997, sequence version 2.
DT 03-AUG-2022, entry version 145.
DE RecName: Full=Uncharacterized MFS-type transporter YdeE;
GN Name=ydeE; Synonyms=ydeF; OrderedLocusNames=b1534, JW1527;
OS Escherichia coli (strain K12).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83333;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=8383113; DOI=10.1128/jb.175.5.1484-1492.1993;
RA Cohen S.P., Haechler H., Levy S.B.;
RT "Genetic and functional analysis of the multiple antibiotic resistance
RT (mar) locus in Escherichia coli.";
RL J. Bacteriol. 175:1484-1492(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=9097039; DOI=10.1093/dnares/3.6.363;
RA Aiba H., Baba T., Fujita K., Hayashi K., Inada T., Isono K., Itoh T.,
RA Kasai H., Kashimoto K., Kimura S., Kitakawa M., Kitagawa M., Makino K.,
RA Miki T., Mizobuchi K., Mori H., Mori T., Motomura K., Nakade S.,
RA Nakamura Y., Nashimoto H., Nishio Y., Oshima T., Saito N., Sampei G.,
RA Seki Y., Sivasundaram S., Tagami H., Takeda J., Takemoto K., Takeuchi Y.,
RA Wada C., Yamamoto Y., Horiuchi T.;
RT "A 570-kb DNA sequence of the Escherichia coli K-12 genome corresponding to
RT the 28.0-40.1 min region on the linkage map.";
RL DNA Res. 3:363-377(1996).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA Shao Y.;
RT "The complete genome sequence of Escherichia coli K-12.";
RL Science 277:1453-1462(1997).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=16738553; DOI=10.1038/msb4100049;
RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT and W3110.";
RL Mol. Syst. Biol. 2:E1-E5(2006).
RN [5]
RP FUNCTION.
RC STRAIN=K12 / JM101 / ATCC 33876 / DSM 3948 / NCIMB 11926;
RX PubMed=20067529; DOI=10.1111/j.1574-6968.2009.01879.x;
RA Hayashi M., Tabata K., Yagasaki M., Yonetani Y.;
RT "Effect of multidrug-efflux transporter genes on dipeptide resistance and
RT overproduction in Escherichia coli.";
RL FEMS Microbiol. Lett. 304:12-19(2010).
CC -!- FUNCTION: A transporter able to export peptides. When overexpressed,
CC allows cells deleted for multiple peptidases (pepA, pepB, pepD and
CC pepN) to grow in the presence of dipeptides Ala-Gln or Gly-Tyr which
CC otherwise inhibit growth (PubMed:20067529). Cells overexpressing this
CC protein have decreased intracellular levels of Ala-Gln dipeptide, and
CC in a system that produces the Ala-Gln dipeptide overproduction of this
CC protein increases export of the dipeptide (PubMed:20067529).
CC {ECO:0000269|PubMed:20067529}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Multi-pass
CC membrane protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=M96235; Type=Frameshift; Note=Produces two separate ORFS.; Evidence={ECO:0000305};
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DR EMBL; M96235; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; U00096; AAC74607.1; -; Genomic_DNA.
DR EMBL; AP009048; BAA15224.2; -; Genomic_DNA.
DR PIR; A64908; A64908.
DR RefSeq; NP_416051.1; NC_000913.3.
DR RefSeq; WP_001054204.1; NZ_LN832404.1.
DR AlphaFoldDB; P31126; -.
DR SMR; P31126; -.
DR BioGRID; 4259113; 150.
DR STRING; 511145.b1534; -.
DR TCDB; 2.A.1.2.55; the major facilitator superfamily (mfs).
DR PaxDb; P31126; -.
DR PRIDE; P31126; -.
DR EnsemblBacteria; AAC74607; AAC74607; b1534.
DR EnsemblBacteria; BAA15224; BAA15224; BAA15224.
DR GeneID; 946083; -.
DR KEGG; ecj:JW1527; -.
DR KEGG; eco:b1534; -.
DR PATRIC; fig|1411691.4.peg.732; -.
DR EchoBASE; EB1595; -.
DR eggNOG; COG2814; Bacteria.
DR HOGENOM; CLU_001265_60_0_6; -.
DR InParanoid; P31126; -.
DR OMA; WESNLSV; -.
DR PhylomeDB; P31126; -.
DR BioCyc; EcoCyc:YDEF-MON; -.
DR PRO; PR:P31126; -.
DR Proteomes; UP000000318; Chromosome.
DR Proteomes; UP000000625; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IDA:EcoCyc.
DR GO; GO:0071916; F:dipeptide transmembrane transporter activity; IMP:EcoCyc.
DR GO; GO:0035442; P:dipeptide transmembrane transport; IMP:EcoCyc.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0055085; P:transmembrane transport; IBA:GO_Central.
DR Gene3D; 1.20.1250.20; -; 1.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR Pfam; PF07690; MFS_1; 1.
DR SUPFAM; SSF103473; SSF103473; 1.
DR PROSITE; PS50850; MFS; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Membrane; Peptide transport;
KW Protein transport; Reference proteome; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..395
FT /note="Uncharacterized MFS-type transporter YdeE"
FT /id="PRO_0000084896"
FT TRANSMEM 12..34
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 44..66
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 75..94
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 99..121
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 134..156
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 160..182
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 208..230
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 245..264
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 271..293
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 298..320
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 341..360
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 364..381
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CONFLICT 27
FT /note="L -> V (in Ref. 1; M96235)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 395 AA; 42659 MW; 223F27AE18AC4F48 CRC64;
MNLSLRRSTS ALLASSLLLT IGRGATLPFM TIYLSRQYSL SVDLIGYAMT IALTIGVVFS
LGFGILADKF DKKRYMLLAI TAFASGFIAI TLVNNVTLVV LFFALINCAY SVFATVLKAW
FADNLSSTSK TKIFSINYTM LNIGWTIGPP LGTLLVMQSI NLPFWLAAIC SAFPMLFIQI
WVKRSEKIIA TETGSVWSPK VLLQDKALLW FTCSGFLASF VSGAFASCIS QYVMVIADGD
FAEKVVAVVL PVNAAMVVTL QYSVGRRLNP ANIRALMTAG TLCFVIGLVG FIFSGNSLLL
WGMSAAVFTV GEIIYAPGEY MLIDHIAPPE MKASYFSAQS LGWLGAAINP LVSGVVLTSL
PPSSLFVILA LVIIAAWVLM LKGIRARPWG QPALC
