YDFH_BACSU
ID YDFH_BACSU Reviewed; 407 AA.
AC P96685; Q797G6;
DT 05-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1997, sequence version 1.
DT 03-AUG-2022, entry version 131.
DE RecName: Full=Sensor histidine kinase YdfH;
DE EC=2.7.13.3;
GN Name=ydfH; OrderedLocusNames=BSU05410;
OS Bacillus subtilis (strain 168).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX NCBI_TaxID=224308;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=168;
RA Kasahara Y., Nakai S., Lee S., Sadaie Y., Ogasawara N.;
RT "A 148 kbp sequence of the region between 35 and 47 degree of the Bacillus
RT subtilis genome.";
RL Submitted (MAR-1997) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=168;
RX PubMed=9384377; DOI=10.1038/36786;
RA Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA Yoshikawa H., Danchin A.;
RT "The complete genome sequence of the Gram-positive bacterium Bacillus
RT subtilis.";
RL Nature 390:249-256(1997).
RN [3]
RP FUNCTION.
RX PubMed=11717295; DOI=10.1128/jb.183.24.7365-7370.2001;
RA Kobayashi K., Ogura M., Yamaguchi H., Yoshida K., Ogasawara N., Tanaka T.,
RA Fujita Y.;
RT "Comprehensive DNA microarray analysis of Bacillus subtilis two-component
RT regulatory systems.";
RL J. Bacteriol. 183:7365-7370(2001).
RN [4]
RP FUNCTION.
RC STRAIN=168;
RX PubMed=15941986; DOI=10.1099/mic.0.27619-0;
RA Serizawa M., Sekiguchi J.;
RT "The Bacillus subtilis YdfHI two-component system regulates the
RT transcription of ydfJ, a member of the RND superfamily.";
RL Microbiology 151:1769-1778(2005).
CC -!- FUNCTION: Member of the two-component regulatory system YdfH/YdfI. May
CC activate YdfI by phosphorylation. {ECO:0000269|PubMed:11717295,
CC ECO:0000269|PubMed:15941986}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC histidine.; EC=2.7.13.3;
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
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DR EMBL; AB001488; BAA19375.1; -; Genomic_DNA.
DR EMBL; AL009126; CAB12348.1; -; Genomic_DNA.
DR PIR; F69780; F69780.
DR RefSeq; NP_388422.1; NC_000964.3.
DR RefSeq; WP_010886422.1; NZ_JNCM01000031.1.
DR AlphaFoldDB; P96685; -.
DR SMR; P96685; -.
DR STRING; 224308.BSU05410; -.
DR PaxDb; P96685; -.
DR PRIDE; P96685; -.
DR EnsemblBacteria; CAB12348; CAB12348; BSU_05410.
DR GeneID; 938076; -.
DR KEGG; bsu:BSU05410; -.
DR PATRIC; fig|224308.179.peg.580; -.
DR eggNOG; COG4585; Bacteria.
DR InParanoid; P96685; -.
DR OMA; MIVIITY; -.
DR PhylomeDB; P96685; -.
DR BioCyc; BSUB:BSU05410-MON; -.
DR Proteomes; UP000001570; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR Gene3D; 3.30.565.10; -; 1.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR011712; Sig_transdc_His_kin_sub3_dim/P.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF07730; HisKA_3; 1.
DR SMART; SM00387; HATPase_c; 1.
DR SUPFAM; SSF55874; SSF55874; 1.
PE 3: Inferred from homology;
KW ATP-binding; Cell membrane; Kinase; Membrane; Nucleotide-binding;
KW Phosphoprotein; Reference proteome; Transferase; Transmembrane;
KW Transmembrane helix; Two-component regulatory system.
FT CHAIN 1..407
FT /note="Sensor histidine kinase YdfH"
FT /id="PRO_0000074917"
FT TOPO_DOM 1..25
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 26..46
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 47..67
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 68..78
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 79..99
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 100..120
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 121..125
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 126..146
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 147..150
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 151..171
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 172..407
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 201..402
FT /note="Histidine kinase"
FT MOD_RES 210
FT /note="Phosphohistidine; by autocatalysis"
FT /evidence="ECO:0000250"
SQ SEQUENCE 407 AA; 46506 MW; 17CEA71B400C9100 CRC64;
MLIRNPFKDK YYSHDRRALN MLALRVPGLA FILMIYIASI VLQFVSGGWS ILLLYAFTIL
IAIFALLHWH SYRWVKKRVI LYFAVQGLIT FALANLMTGF FILVIIGLYA FLIGQIIGMA
DRRRTFLILY LLLLLVINSA YHLHKGEVLH FIVIAAPIMI VIITYAATFF AQVDEKIKAQ
LTLERLELAH QQVEQLTLQN ERQRMARDLH DTLAQGLVSL NMQLDAIHVH LAKGNTERAK
EIIQQSMKRV KSTIADARSA IDDLRSKSEE IGVLKERITS LMDHFIESTG MACLLDYRLH
QVLDVRTAEN CYYIIGECMT NAAKHAEAKT IWISIWDDEK GRLHLTVKDN GKGFDVEKGK
KKRGHYGLLG IQERVRAING QFNIKSTKLK GTQIEITVPI QGEMQDE
