ID   YDFI_ECOLI              Reviewed;         486 AA.
AC   P77260;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1997, sequence version 1.
DT   03-AUG-2022, entry version 135.
DE   RecName: Full=Uncharacterized oxidoreductase YdfI;
DE            EC=1.-.-.-;
GN   Name=ydfI; OrderedLocusNames=b1542, JW1535;
OS   Escherichia coli (strain K12).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83333;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX   PubMed=9097039; DOI=10.1093/dnares/3.6.363;
RA   Aiba H., Baba T., Fujita K., Hayashi K., Inada T., Isono K., Itoh T.,
RA   Kasai H., Kashimoto K., Kimura S., Kitakawa M., Kitagawa M., Makino K.,
RA   Miki T., Mizobuchi K., Mori H., Mori T., Motomura K., Nakade S.,
RA   Nakamura Y., Nashimoto H., Nishio Y., Oshima T., Saito N., Sampei G.,
RA   Seki Y., Sivasundaram S., Tagami H., Takeda J., Takemoto K., Takeuchi Y.,
RA   Wada C., Yamamoto Y., Horiuchi T.;
RT   "A 570-kb DNA sequence of the Escherichia coli K-12 genome corresponding to
RT   the 28.0-40.1 min region on the linkage map.";
RL   DNA Res. 3:363-377(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA   Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA   Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA   Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA   Shao Y.;
RT   "The complete genome sequence of Escherichia coli K-12.";
RL   Science 277:1453-1462(1997).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX   PubMed=16738553; DOI=10.1038/msb4100049;
RA   Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA   Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT   "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT   and W3110.";
RL   Mol. Syst. Biol. 2:E1-E5(2006).
CC   -!- SIMILARITY: Belongs to the mannitol dehydrogenase family. UxuB
CC       subfamily. {ECO:0000305}.
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DR   EMBL; U00096; AAC74615.1; -; Genomic_DNA.
DR   EMBL; AP009048; BAA15243.1; -; Genomic_DNA.
DR   PIR; A64909; A64909.
DR   RefSeq; NP_416060.1; NC_000913.3.
DR   RefSeq; WP_000527743.1; NZ_LN832404.1.
DR   AlphaFoldDB; P77260; -.
DR   SMR; P77260; -.
DR   BioGRID; 4260873; 7.
DR   IntAct; P77260; 4.
DR   STRING; 511145.b1542; -.
DR   jPOST; P77260; -.
DR   PaxDb; P77260; -.
DR   PRIDE; P77260; -.
DR   EnsemblBacteria; AAC74615; AAC74615; b1542.
DR   EnsemblBacteria; BAA15243; BAA15243; BAA15243.
DR   GeneID; 945861; -.
DR   KEGG; ecj:JW1535; -.
DR   KEGG; eco:b1542; -.
DR   PATRIC; fig|1411691.4.peg.723; -.
DR   EchoBASE; EB3582; -.
DR   eggNOG; COG0246; Bacteria.
DR   HOGENOM; CLU_027324_0_1_6; -.
DR   InParanoid; P77260; -.
DR   OMA; YKPYDNL; -.
DR   PhylomeDB; P77260; -.
DR   BioCyc; EcoCyc:G6816-MON; -.
DR   PRO; PR:P77260; -.
DR   Proteomes; UP000000318; Chromosome.
DR   Proteomes; UP000000625; Chromosome.
DR   GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IBA:GO_Central.
DR   GO; GO:0019594; P:mannitol metabolic process; IEA:InterPro.
DR   Gene3D; 1.10.1040.10; -; 1.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR013328; 6PGD_dom2.
DR   InterPro; IPR000669; Mannitol_DH.
DR   InterPro; IPR013118; Mannitol_DH_C.
DR   InterPro; IPR023027; Mannitol_DH_CS.
DR   InterPro; IPR013131; Mannitol_DH_N.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   Pfam; PF01232; Mannitol_dh; 1.
DR   Pfam; PF08125; Mannitol_dh_C; 1.
DR   PRINTS; PR00084; MTLDHDRGNASE.
DR   SUPFAM; SSF48179; SSF48179; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   PROSITE; PS00974; MANNITOL_DHGENASE; 1.
PE   3: Inferred from homology;
KW   NAD; Oxidoreductase; Reference proteome.
FT   CHAIN           1..486
FT                   /note="Uncharacterized oxidoreductase YdfI"
FT                   /id="PRO_0000170748"
FT   BINDING         24..35
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   486 AA;  53685 MW;  96F3BF07AE114B70 CRC64;
     MGNNLLSAKA TLPVYDLNNL APRIVHLGFG AFHRAHQGVY ADILATEHFS DWGYYEVNLI
     GGEQQIADLQ QQDNLYTVAE MSADVWTARV VGVVKKALHV QIDGLETVLA AMCEPQIAIV
     SLTITEKGYF HSPATGQLML DHPMVAADVQ NPHQPKTATG VIVEALARRK AAGLPAFTVM
     SCDNMPENGH VMRDVVTSYA QAVDVKLAQW IEDNVTFPST MVDRIVPAVT EDTLAKIEQL
     TGVRDPAGVA CEPFRQWVIE DNFVAGRPEW EKAGAELVSD VLPYEEMKLR MLNGSHSFLA
     YLGYLAGYQH INDCMEDEHY RYAAYGLMLQ EQAPTLKVQG VDLQDYANRL IARYSNPALR
     HRTWQIAMDG SQKLPQRMLD SVRWHLAHDS KFDLLALGVA GWMRYVGGVD EQGNPIEISD
     PLLPVIQKAV QSSAEGKARV QSLLAIKAIF GDDLPDNSLF TARVTETYLS LLAHGAKATV
     AKYSVK