ID   YDG7_SCHPO              Reviewed;         321 AA.
AC   Q10494;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   03-AUG-2022, entry version 134.
DE   RecName: Full=Uncharacterized oxidoreductase C26F1.07;
DE            EC=1.-.-.-;
GN   ORFNames=SPAC26F1.07;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
CC   -!- SIMILARITY: Belongs to the aldo/keto reductase family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CU329670; CAA97364.1; -; Genomic_DNA.
DR   PIR; T38413; T38413.
DR   RefSeq; NP_594888.1; NM_001020317.2.
DR   AlphaFoldDB; Q10494; -.
DR   SMR; Q10494; -.
DR   BioGRID; 278565; 2.
DR   STRING; 4896.SPAC26F1.07.1; -.
DR   iPTMnet; Q10494; -.
DR   MaxQB; Q10494; -.
DR   PaxDb; Q10494; -.
DR   PRIDE; Q10494; -.
DR   EnsemblFungi; SPAC26F1.07.1; SPAC26F1.07.1:pep; SPAC26F1.07.
DR   GeneID; 2542088; -.
DR   KEGG; spo:SPAC26F1.07; -.
DR   PomBase; SPAC26F1.07; -.
DR   VEuPathDB; FungiDB:SPAC26F1.07; -.
DR   eggNOG; KOG1577; Eukaryota.
DR   HOGENOM; CLU_023205_0_0_1; -.
DR   InParanoid; Q10494; -.
DR   OMA; TALQYGY; -.
DR   PhylomeDB; Q10494; -.
DR   Reactome; R-SPO-193144; Estrogen biosynthesis.
DR   Reactome; R-SPO-193368; Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol.
DR   Reactome; R-SPO-193775; Synthesis of bile acids and bile salts via 24-hydroxycholesterol.
DR   Reactome; R-SPO-193807; Synthesis of bile acids and bile salts via 27-hydroxycholesterol.
DR   Reactome; R-SPO-196108; Pregnenolone biosynthesis.
DR   Reactome; R-SPO-2162123; Synthesis of Prostaglandins (PG) and Thromboxanes (TX).
DR   Reactome; R-SPO-5365859; RA biosynthesis pathway.
DR   Reactome; R-SPO-5652227; Fructose biosynthesis.
DR   PRO; PR:Q10494; -.
DR   Proteomes; UP000002485; Chromosome I.
DR   GO; GO:0005829; C:cytosol; HDA:PomBase.
DR   GO; GO:0005634; C:nucleus; HDA:PomBase.
DR   GO; GO:0004032; F:alditol:NADP+ 1-oxidoreductase activity; ISO:PomBase.
DR   GO; GO:0019568; P:arabinose catabolic process; ISO:PomBase.
DR   GO; GO:1990748; P:cellular detoxification; TAS:PomBase.
DR   GO; GO:0042843; P:D-xylose catabolic process; ISO:PomBase.
DR   Gene3D; 3.20.20.100; -; 1.
DR   InterPro; IPR020471; AKR.
DR   InterPro; IPR018170; Aldo/ket_reductase_CS.
DR   InterPro; IPR023210; NADP_OxRdtase_dom.
DR   InterPro; IPR036812; NADP_OxRdtase_dom_sf.
DR   Pfam; PF00248; Aldo_ket_red; 1.
DR   PIRSF; PIRSF000097; AKR; 1.
DR   PRINTS; PR00069; ALDKETRDTASE.
DR   SUPFAM; SSF51430; SSF51430; 1.
DR   PROSITE; PS00798; ALDOKETO_REDUCTASE_1; 1.
DR   PROSITE; PS00062; ALDOKETO_REDUCTASE_2; 1.
PE   3: Inferred from homology;
KW   Oxidoreductase; Reference proteome.
FT   CHAIN           1..321
FT                   /note="Uncharacterized oxidoreductase C26F1.07"
FT                   /id="PRO_0000124680"
FT   ACT_SITE        60
FT                   /note="Proton donor"
FT                   /evidence="ECO:0000250"
FT   BINDING         118
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250"
FT   SITE            85
FT                   /note="Lowers pKa of active site Tyr"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   321 AA;  36192 MW;  6B03CB14A726FC0B CRC64;
     MSAEQKYFEN AQNVHFTLAD GSKIPGLGLG TWRSEPNQTK NAVKTALQYG YRHIDAAAIY
     GNEDEVGDGI KESGVPRKDI WVTSKLWCNA HAPEAVPKAL EKTLKDLKLD YLDEYLIHWP
     VSFKTGEDKF PKDKDGNLIY EKNPIEETWK AMEKLLETGK VRHIGLSNFN DTNLERILKV
     AKVKPAVHQM ELHPFLPQTE FVEKHKKLGI HVTAYSPFGN QNTIYESKIP KLIEHETIQK
     IAKSKGEGVT GATIAVSWAI TRGTSVIPKS VNEQRIKSNF KYIPLTKEDM DEINSIGIRA
     RFNQATFSNE PVFAGLEDGR T